Abstract
Six infants, 10 mos.-2½yrs., were evaluated for bronchopulmonary dysplasia (BPD) by concurrent cardiac catheterization and echocardiography. Mean estimated gestational age=30wks; mean birth weight=1350gms. All infants required oxygen and diuretic therapy (mean FIO2 28%). Measurements in room air included oxygen consumption (VO2); oxygen capacity; oxygen saturations; pulmonary artery (PA) and wedge pressures; right ventricular dp/dt (RVdp/dt) and right sided systolic time intervals from a Millar catheter tracing; and derived pulmonary vascular resistance (PVR). Measurements were repeated in 40% and 88% oxygen. Ventricular function and systolic time intervals were measured concurrently by echocardiography. Pulmonary wedge angiograms were performed at the conclusion of study. Mean values in room air were mean PA pressure 32mmHg; RVdp/dt 515mmHg·sec−1; RPEP/RVET 0.271; VO2 132 m1 O2·M2−1 ·min−1; pulmonary flow index 3.4 L·min−1 ·M2−1; PVR 6.7 units; PO255 torr, PCO241 torr, pH 7.37. 2 of 6 children responded to O2 with a significant fall in PA pressure and PVR. The two children who responded had the highest mean PA pressures, PCO2's and PVR's of the group (means 46mmHg, 48 torr and 9.6 units). Echo measurements of RPEP/RVET correlated well with values from the Millar catheter, but neither measurement reflected PVR accurately. LV function studies and pulmonary wedge angiograms were normal. These studies suggest invasive studies may aid in management of children with BPD.
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Berman, W., Yabek, S., Dillon, T. et al. 1246 EVALUATION OF BRONCHOPULMONARY DYSPLASIA BY CARDIAC CATHETERIZATION. Pediatr Res 15 (Suppl 4), 650 (1981). https://doi.org/10.1203/00006450-198104001-01273
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DOI: https://doi.org/10.1203/00006450-198104001-01273