Abstract
Specific insulin binding to erythrocyte receptors has previously been reported to be unaltered in children and adolescents with insulin dependent diabetes mellitus (Ped. 66:385, 1980). We report here that five insulin dependent, fasting, non-ketotic juvenile diabetics from the same close kinship have a significant reduction in the percent insulin bound to erythrocytes (Normal % B/T=8.32±2.71, n=24±1SD vs 4.72%±0.84 for the diabetic children). Three non-diabetic juveniles in the family have an intermediate value of 5.77%±1.08. The youngest family member has normal binding. Scatchard analysis or two-site analysis indicate that the reduced binding is due to a decrease in the number of receptor sites/cell. There is no correlation with circulating plasma insulin values nor with the severity of the diabetes, however, the insulin dependent diabetics have an inordinate degree of ocular complications for the severity of the diabetes. Since diabetes mellitus is a heterogeneous disorder, there may be familial patterns to the abnormality seen with the erythrocyte receptor as in the above patients.
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Stonesifer, L., Elders, M., Herzberq, V. et al. 451 INSULIN BINDING STUDIES IN THE ERYTHROCYTES OF DIABETICS IN ONE KINSHIP. Pediatr Res 15 (Suppl 4), 515 (1981). https://doi.org/10.1203/00006450-198104001-00462
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DOI: https://doi.org/10.1203/00006450-198104001-00462