Abstract
For the phototherapy induced serumbilirubin decrease in Gunn rats, reliable concentration-time-functions could be found for any given starting level (co) and for any type of fluorescent lamps used (i.e. for any effective irradiance Ebili - whereby 8 different fluorescent tubes were tested).
(c = serumbilirubin concentration after illumination k = photolyse constant)
By this simple function it was possible not only to describe the dose-response relationship of phototherapy but also the influence of changes in the trial conditions. For example, we could show in our animal experiments that no upper limitation of the phototherapy effect was reached with rather high effective irradiances - up to Ebili 7.0 mW/cm2.
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Wies, E., Ballowit, Z. & Helg, E. Mathematical Derivation of Dose-Response Relationship Calculations in Phototherapy Based upon an Animal Model. Pediatr Res 14, 1425 (1980). https://doi.org/10.1203/00006450-198012000-00099
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DOI: https://doi.org/10.1203/00006450-198012000-00099