Abstract
Serum sulfate determination by the bariumchloranilate reagent (Bertolacini et al, Analytical Chemistry, 30, 202, 1958; was measured in 60 children with isolated GH deficiency (IGHD), panhypopituitarism, high IR-hGH dwarfism and adults with active acromegaly. In acromegaly serum sulfate levels were subnormally low, where in the syndrome of high plasma IR-hGH the levels were markedly high. In untreated IGHD the basal levels of serum sulfate were variable, within the normal range. Upon institution of hGH therapy the serum sulfate levels of the IGHD patients decreased. We conclude that serum sulfate determinations might be a relatively simple indicator of serum hGH and/or somatomedin activity. Changes in serum sulfate levels seem to reflect the process initiated by hGH, via somatomedin generation, resulting in a higher consumption of sulfate by the target cells, and lowering its serum level.
(++)Established Investigator Chief Scientist's Bureau, Ministry of Health.
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Nevo, Z., Nof, D., Bir-Adler, M. et al. 24: Serum Sulfate Levels and Plasma hGH, in Patients with Low and Excessive hGH Secretion. Pediatr Res 10, 876 (1976). https://doi.org/10.1203/00006450-197610000-00029
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DOI: https://doi.org/10.1203/00006450-197610000-00029