Abstract
We have observed 2 families, each with 2 siblings who have poor speech and developmental retardation, whose mothers took trimethadione during their pregnancies. The affected children have common dysmorphic features: irregular teeth, high arched palate, hypertelorism, v-shaped eyebrows, low-set and backward sloped ears with anteriorly folded helices, epicanthus, and micrognathia. Inconstant features include: short stature, VSD, inguinal hernia and myopia. The other pregnancies of these mothers were: in family I, a spontaneous abortion at 2 months gestation; in family II, 2 normal female births, 1 male stillborn at 7 months gestation, 2 male births who died in the neonatal period with multiple malformations.
Many similarities were noted between these patients and those described by German (Teratology 3: 369, 1970) who reported a high frequency of defects among the offspring of 4 mothers who took trimethadione during pregnancy.
Despite these observations, elucidation of the teratogenicity of trimethadione requires epidemiological analysis of a group of women who took this drug during pregnancy and their offspring.
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Zackai, E., Bass, F., Neiderer, B. et al. DYSMORPHOLOGY, POOR SPEECH AND DEVELOPMENTAL DELAY: A POSSIBLE TRIMETHADIONE TERATOGENIC SYNDROME. Pediatr Res 8, 442 (1974). https://doi.org/10.1203/00006450-197404000-00615
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DOI: https://doi.org/10.1203/00006450-197404000-00615