ABSTRACT
The elucidation of genetic causation of human diseases at the molecular level provides crucial information for developing target specific therapeutic approaches with tremendous implications for disease prevention and treatment. Mutations in many essential genes have been linked to hereditary disorders. However, accurate information on gene architecture and gene annotation is essential for drug discovery as this allows insight into splice variants. Information on disease gene relationships and drug targets is spatially and temporally heterogeneous and complex. Drug discovery is a time consuming, increasingly risky and costly process and one of the prime reasons for this is a lack of reliable drug target prediction methods as reflected by the low clinical target validation success rate. The pharmacy aspect of the drug i.e. formulation, drug delivery and large-scale manufacturing is also given importance. Concurrent mapping of protein interaction networks will be crucial for understanding of the biological system and for predicting the drug response.
