ABSTRACT
Investigating biomolecules is crucial to understanding disease and metabolic processes in living organisms. Biomolecule study requires understanding DNA, RNA, and protein three-dimensional structures. Structural biologists have developed many structure-based computer program techniques to study biomolecule’s complicated structures. These structural algorithms illuminate biomolecular functions. The researchers let the program find molecular properties instead of stating what makes a structure prediction true. They did this because they found that the conventional technique of giving such information can bias an algorithm toward certain traits, preventing it from discovering other informative aspects. After succeeding with proteins, the researchers applied their technique to DNAs or RNAs. This chapter covered most structure-based computational biology algorithms and their benefits and weaknesses.
