ABSTRACT
Dietary polyphenols have been comprehensively explored with regard to their antioxidant, immunomodulant, and anti-inflammatory properties in various inflammatory chronic disorders. The aim of this chapter is to summarize the latest developments about how these compounds can modify the inflammatory pathways associated with arthropathies, including osteoarthritis, rheumatoid arthritis, diseases associated arthritis, and crystal-induced arthritis. Among polyphenols extensively studied for arthritis are quercetin, kaempferol, gallic acid, butein, luteolin, and naringenin. These compounds are capable of inhibiting the expression, activity, and release of a various pro-inflammatory cytokines, chemokines, reactive oxygen species and proteolytic enzymes.This chapter summarizes pharmacokinetics and toxicity profiles of some potent dietary polyphenols. This chapter also discusses recent clinical trials in which dietary polyphenols are studied for therapeutic intervention in arthritis.
