Journal of Lipid Research
Research ArticlesSwitching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases
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This work was supported by a Marie Curie Intra-European Fellowship (J.G.M.M.), the European Union Seventh Framework Programme Marie-Curie ITN ‘Sphingonet’ Grant (289278), the Deutsche Forschungsgemeinschaft Sonderforschungsbereich/SFB944-P14 (J.C.M.H.), and an Incentive Award of the Faculty of Biology/Chemistry from the University of Osnabrück (M.K.). The authors declare that they have no conflicts of interest with the contents of this article.
- Asp
aspartic acid
- CPE
ceramide phosphoethanolamine
- CPI
ceramide phosphoinositol
- ER
endoplasmatic reticulum
- Glu
glutamic acid
- HA
hemagglutinin
- His
histidine
- IMDM
Iscove modified Dulbecco medium
- NBD
nitrobenzooxadiazole
- NBD-Cer
NBD-C6-ceramide
- NBD-CPE
NBD-C6-CPE
- ORF
open reading frame
- PC
phosphatidylcholine, PE, phosphatidylethanolamine
- PI
phosphatidylinositiol
- SMS
sphingomyelin synthase
- SMSr
sphingomyelin synthase-related protein
Abbreviations:
- 1
M. Kol and R. Panatala contributed equally to this article.