Journal of Lipid Research
Research ArticlesEndothelial HO-1 induction by model TG-rich lipoproteins is regulated through a NOX4-Nrf2 pathway1[S]
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- A-CRLP
artificial TG-rich chylomicron remnant-like particle
- Akt1/2i
inhibitor of Akt1 and Akt2
- CMR
chylomicron remnant
- DAPI
4′,6-diamidino-2-phenylindole
- DCF-DA
2′7′-dichlorofluorescein-diacetate
- DHASCO®
DHA from Crypthecodinium cohnii blended with high oleic sunflower oil
- DHR
dihydrorhodamine-1,2,3
- EC
endothelial cell
- HAEC
human aortic endothelial cell
- HO-1
heme oxygenase-1
- HUVEC
human umbilical vein endothelial cell
- MEK
MAPK kinase 1
- NOX
NADPH oxidase
- Nrf2
nuclear factor erythroid 2-related factor 2
- p38MAPK
p38 MAPK
- RNS
reactive nitrogen species
- ROS
reactive oxygen species
- SFA
saturated FA
- SRX
sulfiredoxin
- TBARS
thiobarbituric acid reactive substance
- TRL
TG-rich lipoprotein
- TXNIP
thioredoxin interacting protein
- TXR
thioredoxin reductase
- VCAM-1
vascular cell adhesion molecule-1
Abbreviations:
This work was supported by a UK Biotechnology and Biological Sciences Research Council Project Grant (BB/I005862/1), as part of the Diet and Health Research Industry Club (DRINC) initiative (C.P.D.W-J, principal investigator), and a Doctoral Training Grant (BB/J50015X/1) (R.P.).
- [S]
The online version of this article (available at http://www.jlr.org) contains a supplement.
- 1
The data discussed in this publication have been deposited in NCBI's Gene Expression Omnibus (Latham Birt et al., 2016) and are accessible through GEO Series accession number GSE80067 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80067).