Hostname: page-component-76fb5796d-25wd4 Total loading time: 0 Render date: 2024-04-30T00:37:51.467Z Has data issue: false hasContentIssue false
  • English
  • Français

Population and Family Studies in Depression and Mania

Published online by Cambridge University Press:  06 August 2018

J. Mendlewicz
J. Mendlewicz*
Affiliation:
Hopital Erasme, Cliniques Universitaires de Bruxelles, Belgium
Get access Rights & Permissions [Opens in a new window]

Extract

Recent progress in molecular genetics and neurobiology has attracted much attention and provided a new insight into the nature-nurture controversy in respect of the aetiology of psychiatric disorders. Affective illness, including the various subtypes of depressive and manic syndromes, has been the subject of a considerable amount of research on the relative importance of hereditary and environmental factors. This paper provides a critical review of the most relevant literature on the genetics of depression and mania.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue S3: Progress in Antidepressant Therapy , September 1988 , pp. 16 - 25
Copyright
Copyright © 1988 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Angst, J. (1966) Zur Atiologie und Nosologie endogener depressiver Psychosen. Monographien aus dem Gesamtgebrete der Neurologie und Psychiatrie. Berlin: Springer.CrossRefGoogle Scholar
Barker, J. B., Theillie, A. & Spielberger, C. D. (1961) Frequency of blood types in an homogenous group of manic-depressive patients. Journal of Mental Science, 107, 936–942.Google Scholar
Baron, M., Rish, N., Hamburger, R. et al (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289–292.CrossRefGoogle ScholarPubMed
Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish study of manic-depressive disorders. British Journal of Psychiatry, 130, 330–351.CrossRefGoogle ScholarPubMed
Böök, J. A. (1953) A genetic and neuropsychiatric investigation of a North-Swedish population. Acta Geneticae Medica et Genellologiae, 4, 1–100.Google ScholarPubMed
Brown, R. J., Elston, R. C., Pollitzer, W. S., Prange, A. & Wilson, E. (1973) Sex-ratio in relatives of patients with affective disorder. Biological Psychiatry, 6, 307–309.Google ScholarPubMed
Cadoret, R. J. (1978) Evidence for genetic inheritance of primary affective disorder in adoptees. American Journal of Psychiatry, 134, 463–466.Google Scholar
Cooper, J. E., Kendall, R. E., Gurland, B. J., Sharp, L., Copeland, J. R. M. & Simon, R. (1972) Psychiatric diagnosis in New York and London. New York: Oxford University Press.Google Scholar
Da Fonseca, A. F. (1959) Analise heredo-clinica das perturbacoes affectivas. Dissertation, University of Porto.Google Scholar
Del Zompo, M., Bocchetta, A., Goldin, L. R. & Corsini, G. U. (1984) Linkage between X-chromosome markers and manic depressive illness, two Sardinian pedigrees. Acta Psychiatrica Scandinavica, 70, 282–287.CrossRefGoogle ScholarPubMed
Detera-Waldeigh, S. D., Berretini, W. H., Goldin, L. R., Boorman, D., Anderson, S. B. & Gershon, E. S. (1987) Close linkage of C-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature, 325, 806–808.CrossRefGoogle Scholar
Egeland, J. A., Gerhard, D. S., Pauls, D. L., Sussex, J. S., Kidd, K. K., Allen, C. R., Hostetter, A. H. & Housman, D. E. (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783–787.CrossRefGoogle ScholarPubMed
Fischette, C. T., Biegon, A. & McEwan, B. S. (1983) Sex differences in serotonin receptor binding in rat brain. Science, 222, 333–335.CrossRefGoogle ScholarPubMed
Gershon, E. S., Targum, S. D., Matthysse, S. & Bunney, W. E. Jr (1979) Color blindness not closely linked to bipolar illness. Archives of General Psychiatry, 36, 1423–1431.CrossRefGoogle Scholar
Gershon, E. S., Mendlewicz, J., Gastpar, M., Bech, P., Goldin, L. R., Koeholz, P., Rafaelson, O. J., Vartanian, F. & Bunney, W. E. Jr (1980) A collaborative study of genetic linkage of bipolar manic-depressive illness and red/green colour blindness. Acta Psychiatrica Scandinavica, 61, 319–338.CrossRefGoogle Scholar
Goetzl, V., Green, R., Whybrow, P. & Jackson, R. (1974) X-linkage revisited. A further family study of manic-depressive illness. Archives of General Psychiatry, 31, 665–672.CrossRefGoogle ScholarPubMed
Harvald, B. & Hauge, M. (1965) Hereditary factors eludicated by twin studies. In Genetics and the Epidemiology of Chronic Diseases (eds Neel, J. V., Shaw, M. W. & Schull, W. J.). Washington, DC: US Department of Health, Education and Welfare.Google Scholar
Helgasson, T. (1964) Epidemiology of mental disorders in Ireland. Acta Psychiatrica Scandinavica, 173 (Suppl.), 1–258.Google Scholar
Hodgkinson, S., Sherrington, R., Gurling, H., Marchbanks, R., Reeders, S., Mallet, J., McInnes, M., Petursson, H. & Brynjolson, J. (1987) Molecular genetic evidence of heterogeneity in manic-depression. Nature, 325, 805–806.CrossRefGoogle ScholarPubMed
Kallmann, F. J. (1954) Genetic principles in manic-depressive psychoses. In Depression (Hoch, P. & Zubin, J.). New York: Grune & Stratton.Google Scholar
Kringlen, E. (1967) Heredity and environment in the functional psychoses. An epidemiological-clinical twin study. Oslo, Norway: Universitstoforlaget.Google Scholar
Kruger, S. D., Turner, J. W. & Kidd, K. K. (1982) The effects of requisite assumptions on linkage analyses of manic-depressive illness with HLA. Biological Psychiatry, 17, 1081–1099.Google ScholarPubMed
Leonhard, K. (1959) Aufteilung der Endogenen Psychosen. Berlin: Akademie-Verlag.Google Scholar
Mendlewicz, J. (1986) X-linked inheritance in affective disorders. In Psychiatry, the slate of the art. Vol. 2. Biological psychiatry, higher nervous activity (eds P. Pichot, P. Berner, R. Wolf & K. Thau).CrossRefGoogle Scholar
Mendlewicz, J. & Baron, M. (1981) Morbidity risks in subtypes of unipolar depressive illness; differences between early and late onset forms. British Journal of Psychiatry, 139, 463–466.CrossRefGoogle ScholarPubMed
Mendlewicz, J. & Fleiss, J. (1974) Linkage studies with X-chromosome markers in bipolar (manic-depressive) and unipolar (depressive) illness. Biological Psychiatry, 9, 261–294. (Abstracted in Excerpta Medica, Psychiatry, 32, 3, 142, 1975).Google Scholar
Mendlewicz, J. & Rainer, J. D. (1974) Morbidity risk and genetic transmission in manic-depressive illness. American Journal of Human Genetics, 26, 692–701.Google ScholarPubMed
Mendlewicz, J. & Rainer, J. D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature, 268, 327–329.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Fieve, R. C., Rainer, J. D. & Fleiss, J. L. (1972a) Manic-depressive illness; a comparative study of patients with and without a family history. British Journal of Psychiatry, 120, 523–530.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1972b) Evidence for X-linkage in the transmission of manic-depressive illness. Journal of the American Medical Association, 222, 1627.Google ScholarPubMed
Mendlewicz, J., Massart-Guiot, T., Wilmotte, J. & Fleiss, J. L. (1974) Blood groups in manic-depressive illness and schizophrenia. Diseases of the Nervous System, 35, 39–41.Google ScholarPubMed
Mendlewicz, J., Fleiss, J. L. & Fieve, R. R. (1975) Linkage studies in affective disorders: the Xg blood group in manic-depressive illness. In Genetics and psychopathology (eds Fieve, R. R., Rosenthal, D. & Bril, H.). Baltimore: Johns Hopkins Press.Google Scholar
Mendlewicz, J., Linkowski, P., Guroff, J. J. & Van Praag, H. M. (1979) Colour blindness linkage to bipolar manic-depressive illness. New evidence. Archives of General Psychiatry, 36, 1442–1447.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Linkowski, P. & Wilmotte, J. (1980) Linkage between glucose-6-phosphate dehydrogenase deficiency and manic-depressive psychoses. British Journal of Psychiatry, 137, 337–342.CrossRefGoogle Scholar
Mendlewicz, J., Simon, P., Charon, F., Brocas, S., Legros, , & Vassart, G. (1987) Polymorphic DNA marker on X chromosome and manic-depression. The Lancet, 1230-1232.CrossRefGoogle ScholarPubMed
Ministry of Health (1969) Statistical report series, No. 4. Psychiatric hospitals and units in England and Wales, in-patients statistics from the mental health enquiry for the years 1964, 1965 and 1966. London: Her Majesty's Stationery Office.Google Scholar
Pascalis, G., Teyssier, J. R., Carre-Pigeon, F. (1985) Presence d'un Xq-fra chez un maniaque; situation du gene de la PMD sur le bras long du chromosome X. Annales Medico-Psychologiques, 146, 594–595.Google Scholar
Perris, C. (1968) Genetic transmission of depressive psychoses. Acta Psychiatrica Scandinavica, 203 (Suppl.), 45–52.CrossRefGoogle ScholarPubMed
Perris, C. (1972) Abnormality on paternal and maternal sides: observations in bipolar manic-depressive and unipolar depressive psychosis. British Journal of Psychiatry, 118, 207–210.CrossRefGoogle Scholar
Price, J. (1968) The genetics of depressive behaviour. In Recent developments in affective disorders (eds A. Coppen & A. Walk). British Journal of Psychiatry, Special Publication No. 2.Google Scholar
Reich, T., Clayton, P. J. & Winokur, G. (1969) Family history studies: V. The genetics of mania. American Journal of Psychiatry, 125, 1358–1359.CrossRefGoogle ScholarPubMed
Reiss, A. L., Feinstein, C., Toomey, K. E., Goldsmith, B., Rosenbaum, K. & Caruso, M. A. (1986) Psychiatric disability associated with the fragile X chromosome. American Journal of Medical Genetics, 23, 393–401.CrossRefGoogle ScholarPubMed
Risch, N. & Baron, M. (1982) X-linkage and genetic heterogeneity in bipolar-related major affective illness; re-analysis of linkage data. Annals of Human Genetics, 46, 153–166.CrossRefGoogle Scholar
Rosanoff, A. J., Handy, L. M. & Rosanoff-Plessett, I. B. A. (1934) The etiology of manic-depressive syndromes with special reference to their occurrence in twins. American Journal of Psychiatry, 91, 725–762.CrossRefGoogle Scholar
Rudin, E. (1923) Ubert Vererbung geistiger Storungen. Zeitschift fur die Gesamte Neurologie und Psychiatrie, 81, 459–496.Google Scholar
Siniscalco, M., Filippi, G. & Latte, B. (1964) Recombination between protan and deutan genes; data on their relative positions in respect of the G6PD locus. Nature, 204, 1061–1064.CrossRefGoogle Scholar
Slater, E. (1953) Psychotic and neurotic illness in twins. Special Report. Medical Research Council Series, 178. London: Her Majesty's Stationery Office.Google ScholarPubMed
Slater, E., Maxwell, J. & Price, J. S. (1972) Distribution of ancestral secondary cases in bipolar affective disorders. British Journal of Psychiatry, 118, 215–218.CrossRefGoogle Scholar
Stenstedt, A. (1952) A study in manic-depressive psychoses. Acta Psychiatrica et Neurologica Scandinavica (Suppl.), 79.Google Scholar
Stromgren, E. (1938) Beitrage zur psychiatrischen Erblehere. Copenhagen: Munksgaart.Google Scholar
Swanson, D. A. (1960) Suicide in identical twins. American Journal of Psychiatry, 116, 934–935.CrossRefGoogle ScholarPubMed
Targum, S. D., Gershon, E. J., Van Eerdewegh, M. & Rogenline, N. (1979) Human leucocyte antigen (HLA) system not closely linked to or associated with bipolar manic-depressive illness. Biological Psychiatry, 14, 615–636.Google ScholarPubMed
Taylor, M. & Abrams, R. (1974) Manic states. A genetic study of early and late onset of affective disorders. Archives of General Psychiatry, 28, 656–672.CrossRefGoogle Scholar
Tomasson, H. (1938) Further investigations on manic-depressive psychoses: investigations on heredity in Ireland. Acta Psychiatrica et Neurologica Scandinavica, 13, 517–526.CrossRefGoogle Scholar
Torgersen, S. (1986) Genetic factors in moderately severe and mild affective disorders. Archives of General Psychiatry, 43, 222–226.CrossRefGoogle ScholarPubMed
Wilmotte, J. (1980) Linkage between glucose-6-phosphate dehydrogenase deficiency and manic depressive psychoses. British Journal of Psychiatry, 137, 337.Google Scholar
Winokur, G. & Crowe, R. R. (1983) Bipolar illness. The sex-polarity effect in affectively ill family members. Archives of General Psychiatry, 40, 57–58.CrossRefGoogle ScholarPubMed
Winokur, G. & Tanna, V. L. (1969) Possible role of X-linked dominant factor in manic-depressive diseases. Diseases of the Nervous System, 30, 89–94.Google Scholar
Winokur, G., Clayton, P. J. & Reich, T. (1969) Manic-depressive illness. St Louis: C. V. Mosby.Google Scholar
Wirtkamp, L. R., Stancer, H. C., Persad, E., Flood, C. & Guttorsmen, S. (1981) Depressive disorders and HLA. A gene on chromosome 6 that can affect behaviour. New England Journal of Medicine, 305, 1301–1306.CrossRefGoogle Scholar
Zerbin-Rüdin, E. (1967) Endogene Psychosen. In Human-Genetik: ein Kurzs Handbuch in Fünf Banden (ed. Becker, P. E.) vol. 2. Stuttgart: Thieme. -(1969) Zur Genetik der Depressiven Erkrankungen. In Das Depressive Syndrom (eds H. Hippius and H. Selbach). Munich: Urban & Schwarsenberg.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.