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A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China

BMC Gastroenterology volume 24, Article number: 48 (2024) Cite this article

Abstract

Purpose

Mesenteric panniculitis (MP) represents the uncommon, benign and chronic inflammatory disorder affecting the mesenteric adipose tissues. Its etiology, diagnosis and treatment remain unnoticed. Our report focused on shedding more lights on this condition.

Patients and methods

Seventeen MP patients were identified by searching the electronic medical record system in the Zhengzhou Ninth People’s Hospital using the search terms “Mesenteric panniculitis” from October 2015 to March 2023. All cases were diagnosed with MP through computed tomography (CT). Their clinical features and treatments were analyzed.

Results

There were altogether 17 cases enrolled for this analysis. The male to female ratio was 8:9, and the median age at diagnosis was 64 (range: 37–96) years. There were 15 patients (88.2%) showing abdominal pain to varying degrees. The proportions of symptoms of nausea, vomiting and fever were 23.5%, 23.5% and 41.2%, respectively. Neoplastic disease was present in 3 patients (17.6%). Meanwhile, 9 patients (52.9%) had gallstones, 3 (17.6%) had cholecystitis and 1 (5.9%) had gallbladder polyps. Six patients (35.3%) received antibiotics treatment only and 1 (5.9%) received oral antibiotics and prednisone. One patient (5.9%) received antibiotics followed by prednisone treatment, because the symptoms were significantly relieved after antibiotic treatment, while the disease recurred soon after, and the symptoms improved again after prednisone treatment. The abdominal pain in 9 patients (52.9%) was relieved spontaneously. Two patients (11.8%) died, including one due to respiratory failure caused by pneumonia and the other one because of pancreatic cancer with lung and liver metastases.

Conclusion

MP is a poorly understood chronic inflammatory disease. Patients often have abdominal pain as the main symptom, accompanied by comorbidities in the gallbladder, and the prognosis is usually good after correct diagnosis and treatment, Therefore, the present report aims to promote the awareness among clinicians of patients with non-classic abdominal symptoms, so as to avoid misdiagnosis or missed diagnosis.

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Introduction

Mesenteric panniculitis (MP) accounts for the disorder characterized by chronic non-specific unexplained inflammation. It was first described as “sclerosing mesenteritis” by Jura in 1924 and further labeled as “MP” by Odgen later in 1965 [1]. In an autopsy study of the mesenterium of all adults during a period of 6 months, 9 out of 712 autopsies (1.26%) showed mesenteritis [2]. Combined with most literature reports, the incidence of mesenteritis is about 0.16-3.4% [3, 4]. Most studies have indicated that MP is more commonly found among men, and the male-to-female ratio is 2–3:1 [5]. At present, the precise pathophysiological mechanism of MP is still unclear, but it is probably associated with various conditions like abdominal trauma/surgery, cancer, inflammatory disease, mesenteric ischemia, obesity [6], acute pancreatitis [7], autoimmune disease [8, 9], Coronavirus Disease (COVID-19) [10] and so on. This work focused on investigating the clinical characteristics and treatment in 17 MP cases.

Materials and methods

The present retrospective study was conducted from October 2015 to March 2023. In total, 17 patients with MP were identified by searching the electronic medical record system in Zhengzhou Ninth People’s Hospital using the search term “Mesenteric panniculitis”.

These cases were all diagnosed through computed tomography (CT) by an independent radiologist to review the images. The initial of the radiologist was “ZZ”. In this work, we eliminated cases known to display the CT findings close to MP (namely, recent mesenteric trauma, mesenteric edema, mesenteric lymphoma or portal hypertension).

CT analysis

CT findings evaluated in the present work were depicted previously for MP patients in literature reports, including hyper-attenuation of mesenteric fat called the “misty mesentery”, and fat halo sign around nodules and/or vessels [4, 6, 11, 12]. In the present work, MP was confirmed in the presence of hyper-attenuation of mesenteric fat (Fig. 1), which has been most extensively mentioned for MP in previous studies [4, 11].

Fig. 1
figure 1

A 96-year-old man with abdominal pain on the right side. Plain abdominal CT revealed hyper-attenuation of mesenteric fat (A). After antibiotic treatment, the abdominal pain was mitigated but soon worsened (B). The abdominal pain was gradually controlled following the initiation of prednisone therapy (40 mg daily), repeat CT revealed less panniculitis (C), and contrast-enhanced CT [iodinated contrast agent, Iohexl Injection, GE HEALTHCARE (Shanghai) Co., Ltd., China] revealed hyper-attenuation of mesenteric root, accompanied by a fat halo sign that surrounded the vessels, which suggested MP (D)

Full size image

Results

In our study, clinical characteristics, treatment as well as long-term outcomes including the risk of recurrence and the impact on quality of life of those seventeen MP patients were analyzed (Table 1). According to our results, the male-to-female ratio was 8:9, and the median age at diagnosis was 64 (range, 37–96) years. There were 15 patients (88.2%) showing abdominal pain to varying degrees. The proportions of symptoms of nausea, vomiting and fever were 23.5%, 23.5% and 41.2%, respectively. Neoplastic disease was present in 3 patients (17.6%). Meanwhile, 9 patients (52.9%) had gallstones, 3 (17.6%) had cholecystitis and 1 (5.9%) had gallbladder polyps. Six patients (35.3%) received antibiotics alone. One (5.9%) took oral antibiotics and prednisone. One (5.9%) received antibiotics followed by prednisone, because the symptoms were significantly relieved after antibiotic treatment, but aggravated soon thereafter, and the symptoms improved again after prednisone treatment. Abdominal pain in 9 patients (52.9%) was relieved spontaneously.

In the long term, only the 96-year-old patient had mild abdominal pain after a few months of interruption, which was gradually relieved after oral administration of prednisone at 40 mg/day. The drug was tapered to withdrawal. The disease had no impact on the quality of life. Two patients (11.8%) died, including one due to respiratory failure caused by pneumonia and the other one because of pancreatic cancer with lung and liver metastases.

Table 1 Clinical characteristics and long-term outcomes in 17 mesenteric panniculitis patients
Full size table

Discussion

The pathophysiology of MP remains unknown for the time being [13,14,15]. Typically, MP is also called “mesenteric lipodystrophy”, “mesenteric panniculitis”, “retractile mesenteritis” and “sclerosing mesenteritis”. The above terms mostly represent the characteristic histopathological variants featuring one typical mesenteric inflammation type with no involvement of vessel, lymph node and adjacent gut [15, 16]. It can be divided into three distinct stages [11, 14, 17]. In stage 1, also known as “mesenteric lipodystrophy”, mesenteric fat will be substituted by the foamy macrophages, and there was almost no inflammatory alterations on imaging findings [16]. It is usually asymptomatic. Stage 2, also referred to as “mesenteric panniculitis”, is characterized by inflammation, with infiltration of plasma cells, polymorphonuclear leukocytes, and foamy macrophages [16, 18]. Patients in this stage have abdominal pain, nausea and vomiting, fever and fatigue [19]. Stage 3, also called “retractile mesenteritis”, shows the typical feature of fibrosis, collagen deposition, as well as abdominal mass formation. The above-mentioned stages may co-exist or take place in a specific order, rather than separated from each other. Because serial biopsies were lacking, it was impossible to objectively establish the progression [20]. Pathological alterations in every stage involve the intestinal submucosal and mesenteric fats, which usually extend to submucosa and intestinal muscles. Intact mucosal structure is still observed [21]. In a series of studies on CT scans for a 5-year follow-up period, most patients (70.2–96.5%) had stable disease, 8–27% of them showed spontaneous resolution of symptoms, and a low proportion (2.3–16%) had disease progression [3, 4, 22,23,24,25].

The symptoms and signs of MP are nonspecific [20]. Typically, the most common complaint described in the literature is abdominal pain [1, 3, 16]. While there are many causes of abdominal pain. Therefore, it is necessary to judge the acute or chronic onset, location, nature and degree of abdominal pain in patients. When the medical history and physical examination are not sufficient to determine the pathological changes in the abdomen, especially in patients with acute abdomen of unknown etiology, CT examination can be considered [3]. CT scans vary depending on the severity of inflammation, and the findings observed include inflammatory soft tissue mass, pseudocapsule, ground-glass appearance of the mesenteric fat, fat ring sign, fatty haziness, and calcification caused by necrosis of adipose tissue [22]. Coulier [4] put forward the definite diagnosis of MP when 3 of 5 typical characteristics were satisfied: (sign 1) a well-defined “mass effect” on surrounding tissues without invasion; (sign 2) hyper-attenuation of mesenteric fat tissue compared with surrounding mesocolonic or retroperitoneal fat; (sign 3) presence of small soft tissue nodes (< 10 mm); (sign 4) the hypo-attenuation of fatty “halo sign”; and (sign 5) hyper-attenuation of pseudocapsule probably surrounding the whole entity. Notably, those last two signs may be inconstant yet quite specific.

Ultrasound examination has also been used in the diagnosis of MP, which probably reveal the well-defined hyper-attenuation of mesenteric mass with small hypo-attenuation of the center [26, 27]. Magnetic resonance imaging (MRI) shows one mesenteric mass that has a moderate signal intensity on T1 [28]. Whereas on T2-weighted images, the intensities can be different according to fibrosis (hypointensity) and edema (hyperintensity) levels [29]. Only a very few cases with ultrasound and MRI evaluation have been reported and standardized definitions are lacking.

Laboratory findings on MP are usually related to underlying inflammation; for instance, the incidence of leukocytosis is reported to be 16% [3, 18]. The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) increased in 14–88% [18, 30], and low albumin is found in 5% of patients [18].

The diagnosis of MP is often made empirically based on the characteristic radiographic findings [31], pathology remains the gold standard. Biopsy is always performed in laparotomy or exploratory laparoscopy [32].

There is no guideline for the treatment of MP in the world [5, 33, 34]. MP is rare, which has added to the difficulty in assessing its therapeutic responses, leading to the empiric options. They are derived on the basis of individual cases, without using a specific method for determining symptom severity [34]. Corticosteroids, which are usually used as the initial therapy targeting the inflammatory component, show rapid and excellent responses. However, their long-term use is associated with certain complications such as hyperglycemia and peripheral neuropathy, which have limited their clinical application [5, 35]. Azathioprine, as the immunosuppressive agent with the longest history, has been widely used in the treatment of different diseases like inflammatory bowel disease and rheumatologic diseases [36, 37]. Bala et al. reported a case of MP with abdominal pain and bowel obstruction. The patient became disease free after 5-month treatment with steroid and azathioprine following partial ilectomy [36]. Cyclophosphamide is also effective on MP as an immunosuppressant. R W Bush et al. presented two patients with aggressive form of MP, which was characterized by a progressive, life-threatening course, prominent retroperitoneal lesions, and tubuloreticular structures in one case; besides, in both patients, cyclophosphamide resulted in prompt and dramatic symptom improvements, without disease recurrence [38]. Tamoxifen is a selective estrogen receptor modulator, which has exhibited benefits in patients with MP through the inhibition of fibroblast TGF-β1 production [39, 40]. As indicated in an open-label pilot study, thalidomide was effective on patients with symptomatic MP through exerting the anti-inflammatory properties [41]. Andreas N Kapsoritakis et al. described a 62-year old man with MP, who presented with pulmonary tuberculosis after initial therapy with corticosteroids. The patient was subsequently treated with pentoxifylline, with substantial clinical and radiological improvements [42]. Fasoulas et al. reported a case of MP in whom steroid dependence was successfully managed with colchicine without any recurrence [43]. R Mazure et al. described a patient with MP refractory to surgery who achieved a good response to oral progesterone (10 mg/day for 6 months) with complete disappearance of tumor mass and clinical symptoms [44], which might be associated with their fibrinolytic characteristics [45]. Some studies have also reported a good clinical response of MP to antibiotics, particularly for patients with elevated inflammatory markers [46, 47], similar to our results. In a small study involving 92 patients, it was reported that tamoxifen combined with prednisone led to significant symptomatic improvements in 60% of patients [30]. Surgery may be attempted if medical therapy fails or in the presence of life-threatening complications such as bowel obstruction or perforation [48]. Table 2 summarizes the different treatment options for MP, including the risks and benefits of each approach and their evidence level.

Table 2 Different treatment options for mesenteric panniculitis
Full size table

Typically, many patients may have abdominal pain, abdominal fullness, diarrhea, anorexia, nausea, weight loss or intestinal obstruction. MP patients with biliary dyskinesia are rare [49]. Due to the varying clinical presentations, it is challenging to make a definite diagnosis among these patients. Because of the close association of MP with malignancy [14, 35, 50,51,52,53,54], an initial evaluation that includes appropriate testing to rule out malignancies is a critical part of patient care. Therefore, a multidisciplinary discussion is needed. If MP is not diagnosed timely, worst outcomes and even death may occur in patients with acute abdominal complications such as intestinal perforation, ischemia or obstruction [5, 30, 55,56,57,58,59]. Occasionally, MP or its treatment can prove fatal [30, 60]. Prabin Sharma et al. conducted one systematic review on 192 MP patients, and they reported the frequent complications like bowel obstruction/ischemia (n = 10, 23.8%) or obstructive uropathy/renal failure (n = 10, 23.8%). Altogether 14 death cases were observed, including 12 (85.7%) dying of MP-associated complications [18]. Generally speaking, if MP patients respond well to the drugs, they have good prognosis [30].

Conclusion

Little is known about the chronic inflammatory disorder MP. It accounts for a rare cause of non-classic abdominal symptoms. The etiology of MP is still unclear. Based on our report, prednisone appears to be effective. Therefore, clinicians should be aware of this disease and carefully solicit the history of one patient, since a simple denial can be misleading. More investigations are needed to shed more lights on MP and its optimum treatment.

Data availability

All data utilized and/or analysed in this work can be obtained from the corresponding author upon reasonable request.

Abbreviations

MP:

Mesenteric panniculitis

CT:

computed tomography

COVID-19:

Coronavirus Disease

CRP:

C-reactive protein

ESR:

erythrocyte sedimentation rate

References

  1. Ogden WW, 2nd, Bradburn DM, Rives JD. Mesenteric panniculitis: review of 27 cases. Ann Surg. 1965;161(6):864–75.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kuhrmeier A. [Mesenteric lipodystrophy]. Schweizerische Medizinische Wochenschrift. 1985;115(36):1218–24.

    CAS  PubMed  Google Scholar 

  3. Daskalogiannaki M, Voloudaki A, Prassopoulos P, Magkanas E, Stefanaki K, Apostolaki E, Gourtsoyiannis N. CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol. 2000;174(2):427–31.

    Article  CAS  PubMed  Google Scholar 

  4. B. Mesenteric panniculitis. Part 2: prevalence and natural course: MDCT prospective study. JBR-BTR: organe de la Societe royale belge de radiologie (SRBR) = Orgaan Van De Koninklijke Belgische Vereniging Voor Radiologie (KBVR). 2011;94(5):241–6.

  5. Issa I, Baydoun H. Mesenteric panniculitis: various presentations and treatment regimens. World J Gastroenterol. 2009;15(30):3827–30.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Buragina G, Magenta Biasina A, Carrafiello G. Clinical and radiological features of mesenteric panniculitis: a critical overview. Acta bio-medica: Atenei Parmensis. 2019;90(4):411–22.

    PubMed  Google Scholar 

  7. Mohamed H, Mehdi C, Ikram M, Myriam M, Habib B, Adnene C. [Mesenteric panniculitis associated with acute pancreatitis: about a case]. Pan Afr Med J. 2016;24:206.

    PubMed  PubMed Central  Google Scholar 

  8. Rolff HC, Fallentin E, Wettergren A. [Mesenteric panniculitis is a rare inflammation of the mesenteric adipose tissue]. Ugeskr Laeger. 2011;173(20):1437–8.

    PubMed  Google Scholar 

  9. Watanabe I, Taneichi K, Baba Y, Sakai I, Chimoto T, Shibaki H. [A case of mixed connective tissue disease with mesenteric panniculitis]. Nihon Naika Gakkai Zasshi The Journal of the Japanese Society of Internal Medicine. 1989;78(1):93–4.

    Article  CAS  PubMed  Google Scholar 

  10. Mandala S, Kodati R. An unusual cause of Acute Abdominal Pain in Coronavirus Disease (COVID-19): report of two cases. 2022;26(9):1045–8.

  11. B. Mesenteric panniculitis. Part 1: MDCT–pictorial review. JBR-BTR: organe de la Societe royale belge de radiologie (SRBR) = Orgaan Van De Koninklijke Belgische Vereniging Voor Radiologie (KBVR). 2011;94(5):229–40.

  12. Mindelzun RE, Jeffrey RB Jr., Lane MJ, Silverman PM. The misty mesentery on CT: differential diagnosis. AJR Am J Roentgenol. 1996;167(1):61–5.

    Article  CAS  PubMed  Google Scholar 

  13. White B, Kong A, Chang AL. Sclerosing mesenteritis. Australas Radiol. 2005;49(2):185–8.

    Article  CAS  PubMed  Google Scholar 

  14. Kipfer RE, Moertel CG, Dahlin DC. Mesenteric lipodystrophy. Ann Intern Med. 1974;80(5):582–8.

    Article  CAS  PubMed  Google Scholar 

  15. Schäffler A, Müller-Ladner U, Schölmerich J, Büchler C. Role of adipose tissue as an inflammatory organ in human diseases. Endocr Rev. 2006;27(5):449–67.

    Article  PubMed  Google Scholar 

  16. Emory TS, Monihan JM, Carr NJ, Sobin LH. Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity? Am J Surg Pathol. 1997;21(4):392–8.

    Article  CAS  PubMed  Google Scholar 

  17. van Lingen CP, Zeebregts CJ, Gerritsen JJ, Klaase JM, van Baarlen J. Mesenteric panniculitis presenting as colitis. ANZ J Surg. 2004;74(3):176.

    Article  PubMed  Google Scholar 

  18. Sharma P, Yadav S, Needham CM, Feuerstadt P. Sclerosing mesenteritis: a systematic review of 192 cases. Clin J Gastroenterol. 2017;10(2):103–11.

    Article  CAS  PubMed  Google Scholar 

  19. Hussein MRA, Abdelwahed SR. Mesenteric panniculitis: an update. Expert Rev Gastroenterol Hepatol. 2015;9(1):67–78.

    Article  CAS  PubMed  Google Scholar 

  20. Danford CJ, Lin SC, Wolf JL. Sclerosing Mesenteritis. Am J Gastroenterol. 2019;114(6):867–73.

    Article  PubMed  Google Scholar 

  21. Wat SY, Harish S, Winterbottom A, Choudhary AK, Freeman AH. The CT appearances of sclerosing mesenteritis and associated diseases. Clin Radiol. 2006;61(8):652–8.

    Article  CAS  PubMed  Google Scholar 

  22. van Putte-Katier N, van Bommel EF, Elgersma OE, Hendriksz TR. Mesenteric panniculitis: prevalence, clinicoradiological presentation and 5-year follow-up. Br J Radiol. 2014;87(1044):20140451.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Gögebakan Ö, Albrecht T, Osterhoff MA, Reimann A. Is mesenteric panniculitis truely a paraneoplastic phenomenon? A matched pair analysis. Eur J Radiol. 2013;82(11):1853–9.

    Article  PubMed  Google Scholar 

  24. Buchwald P, Diesing L, Dixon L, Wakeman C, Eglinton T, Dobbs B, Frizelle F. Cohort study of mesenteric panniculitis and its relationship to malignancy. Br J Surg. 2016;103(12):1727–30.

    Article  CAS  PubMed  Google Scholar 

  25. Badet N, Sailley N, Briquez C, Paquette B, Vuitton L, Delabrousse É. Mesenteric panniculitis: still an ambiguous condition. Diagn Interv Imaging. 2015;96(3):251–7.

    Article  CAS  PubMed  Google Scholar 

  26. Rosón N, Garriga V, Cuadrado M, Pruna X, Carbó S, Vizcaya S, Peralta A, Martinez M, Zarcero M, Medrano S. Sonographic findings of mesenteric panniculitis: correlation with CT and literature review. J Clin Ultrasound: JCU. 2006;34(4):169–76.

    Article  PubMed  Google Scholar 

  27. Sato M, Ishida H, Konno K, Komatsuda T, Naganuma H, Watanabe S, Ohyama Y, Itoh M, Mukojima T, Sakai T. Mesenteric panniculitis: sonographic findings. Abdom Imaging. 2000;25(2):142–5.

    Article  CAS  PubMed  Google Scholar 

  28. Kronthal AJ, Kang YS, Fishman EK, Jones B, Kuhlman JE, Tempany CM. MR imaging in sclerosing mesenteritis. AJR Am J Roentgenol. 1991;156(3):517–9.

    Article  CAS  PubMed  Google Scholar 

  29. Fujiyoshi F, Ichinari N, Kajiya Y, Nishida H, Shimura T, Nakajo M, Matsunaga Y, Furoi A, Imaguma M. Retractile mesenteritis: small-bowel radiography, CT, and MR imaging. AJR Am J Roentgenol. 1997;169(3):791–3.

    Article  CAS  PubMed  Google Scholar 

  30. Akram S, Pardi DS, Schaffner JA, Smyrk TC. Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatology: Official Clin Pract J Am Gastroenterological Association. 2007;5(5):589–96. quiz 523–584.

    Article  Google Scholar 

  31. Ehrenpreis ED, Roginsky G, Gore RM. Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms. World J Gastroenterol. 2016;22(48):10601–8.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Zhao ME, Zhang LQ, Ren L, Li ZW, Xu XL, Wang HJ, Wang ZX, Li HL, Bao YY, Fan HN. A case report of mesenteric panniculitis. 2019, 47(7):3354–9.

  33. Popkharitov AI, Chomov GN. Mesenteric panniculitis of the sigmoid colon: a case report and review of the literature. J Med Case Rep. 2007;1:108.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Hussein MR, Abdelwahed SR. Mesenteric panniculitis: an update. Expert Rev Gastroenterol Hepatol. 2015;9(1):67–78.

    Article  CAS  PubMed  Google Scholar 

  35. Goh J, Otridge B, Brady H, Breatnach E, Dervan P, MacMathuna P. Aggressive multiple myeloma presenting as mesenteric panniculitis. Am J Gastroenterol. 2001;96(1):238–41.

    Article  CAS  PubMed  Google Scholar 

  36. Bala A, Coderre SP, Johnson DR, Nayak V. Treatment of sclerosing mesenteritis with corticosteroids and azathioprine. Can J Gastroenterol = J canadien de gastroenterologie. 2001;15(8):533–5.

    Article  CAS  Google Scholar 

  37. Maltzman JS, Koretzky GA. Azathioprine: old drug, new actions. J Clin Investig. 2003;111(8):1122–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Bush RW, Hammar SP Jr., Rudolph RH. Sclerosing mesenteritis. Response to cyclophosphamide. Arch Intern Med. 1986;146(3):503–5.

    Article  CAS  PubMed  Google Scholar 

  39. Guest S. Tamoxifen therapy for encapsulating peritoneal sclerosis: mechanism of action and update on clinical experiences. Perit dialysis International: J Int Soc Perit Dialysis. 2009;29(3):252–5.

    Article  CAS  Google Scholar 

  40. Venkataramani A, Behling CA, Lyche KD. Sclerosing mesenteritis: an unusual cause of abdominal pain in an HIV-positive patient. Am J Gastroenterol. 1997;92(6):1059–60.

    CAS  PubMed  Google Scholar 

  41. Ginsburg PM, Ehrenpreis ED. A pilot study of thalidomide for patients with symptomatic mesenteric panniculitis. Aliment Pharmacol Ther. 2002;16(12):2115–22.

    Article  CAS  PubMed  Google Scholar 

  42. Kapsoritakis AN, Rizos CD, Delikoukos S, Kyriakou D, Koukoulis GK, Potamianos SP. Retractile mesenteritis presenting with malabsorption syndrome. Successful treatment with oral pentoxifylline. J Gastrointest Liver Diseases: JGLD. 2008;17(1):91–4.

    Google Scholar 

  43. Fasoulas K, Beltsis A, Katsinelos T, Dimou E, Arvaniti M, Charsoula A, Gourvas V, Atmatzidis S, Chatzimavroudis G, Katsinelos P. Efficacy of colchicine in the treatment of mesenteric panniculitis in a young patient. Saudi J Gastroenterology: Official J Saudi Gastroenterol Association. 2012;18(2):146–8.

    Article  Google Scholar 

  44. Mazure R, Fernandez Marty P, Niveloni S, Pedreira S, Vazquez H, Smecuol E, Kogan Z, Boerr L, Mauriño E, Bai JC. Successful treatment of retractile mesenteritis with oral progesterone. Gastroenterology. 1998;114(6):1313–7.

    Article  CAS  PubMed  Google Scholar 

  45. Cuff R, Landercasper J, Schlack S. Sclerosing mesenteritis. Surgery. 2001;129(4):509–10.

    CAS  PubMed  Google Scholar 

  46. Kaya C, Bozkurt E. Approach to the diagnosis and treatment of mesenteric panniculitis from the surgical point of view. 2018, 34(2):121–4.

  47. Sahin A, Artas H, Eroglu Y, Tunc N, Demirel U, Bahcecioglu IH, Yalniz M. An overlooked potentially treatable disorder: idiopathic mesenteric panniculitis. Med Principles Practice: Int J Kuwait Univ Health Sci Centre. 2017;26(6):567–72.

    Article  Google Scholar 

  48. Gu GL, Wang SL, Wei XM, Ren L, Li DC, Zou FX. Sclerosing mesenteritis as a rare cause of abdominal pain and intraabdominal mass: a cases report and review of the literature. Cases J. 2008;1(1):242.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Patel A, Alkawaleet Y, Young M, Reddy C. Mesenteric panniculitis: an unusual presentation of Abdominal Pain. Cureus. 2019;11(7):e5100.

    PubMed  PubMed Central  Google Scholar 

  50. Béchade D, Durand X, Desramé J, Rambelo A, Corberand D, Baranger B, Farge D, Algayres JP. [Etiologic spectrum of mesenteric panniculitis: report of 7 cases]. La Revue De Medecine Interne. 2007;28(5):289–95.

    Article  PubMed  Google Scholar 

  51. Okamoto M, Ohkubo N, Yamanaka M, Kimura A, Takagi T, Iwao A, Kawaguchi M, Iwasaki N, Takagi T, Sho KE, et al. [A case of mesenteric panniculitis complicated with malignant lymphoma]. Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of gastro-enterology. 1998;95(8):884–9.

    CAS  PubMed  Google Scholar 

  52. Harris RJ, van Stolk RU, Church JM, Kavuru MS. Thoracic mesothelioma associated with abdominal mesenteric panniculitis. Am J Gastroenterol. 1994;89(12):2240–2.

    CAS  PubMed  Google Scholar 

  53. Güerri Fernández R, Villar García J, García Sirvent L, Garcés Jarque JM. [Mesenteric panniculitis, first clinical manifestation of a disseminated B cell lymphoma]. Rev Clin Esp. 2008;208(2):109–10.

    Article  PubMed  Google Scholar 

  54. Wilkes A, Griffin N, Dixon L, Dobbs B, Frizelle FA. Mesenteric panniculitis: a paraneoplastic phenomenon? Dis Colon Rectum. 2012;55(7):806–9.

    Article  PubMed  Google Scholar 

  55. Buyukkaya A, Gunes H, Ozaydın I, Ozel MA, Buyukkaya R, Sarıtas A. An unusual cause of acute abdominal pain: mesenteric panniculitis. Am J Emerg Med. 2015;33(9):1328e1321–1322.

    Article  Google Scholar 

  56. Duman M, Koçak O, Fazli O, Koçak C, Atici AE, Duman U. Mesenteric panniculitis patients requiring emergency surgery: report of three cases. Turkish J Gastroenterology: Official J Turkish Soc Gastroenterol. 2012;23(2):181–4.

    Article  Google Scholar 

  57. Nasta AM, Patel D, Shrivastav O, Goel M, Shrimal A, Gupte A, Goel R. Mesenteric panniculitis-first Case Series after bariatric surgery. Obes Surg. 2018;28(3):881–5.

    Article  PubMed  Google Scholar 

  58. Durst AL, Freund H, Rosenmann E, Birnbaum D. Mesenteric panniculitis: review of the leterature and presentation of cases. Surgery. 1977;81(2):203–11.

    CAS  PubMed  Google Scholar 

  59. Piessen G, Mariette C, Triboulet JP. [Mesenteric panniculitis]. Ann Chir. 2006;131(2):85–90.

    Article  CAS  PubMed  Google Scholar 

  60. Katsanos KH, Ioachim E, Michail M, Price AC, Agnantis N, Kappas A, Tsianos EV. A fatal case of sclerosing mesenteritis. Dig Liver Disease: Official J Italian Soc Gastroenterol Italian Association Study Liver. 2004;36(2):153–6.

    Article  CAS  Google Scholar 

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  1. Geriatric Center, Zhengzhou Ninth People’s Hospital, 25 Sha Kou Road, 450008, Zhengzhou, Henan, China

    Hongyan Wang, Qiucai Cao & Jing Ning

  2. Radiology, Zhengzhou Ninth People’s Hospital, 25 Sha Kou Road, 450008, Zhengzhou, Henan, China

    Zhenyu Zhao

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HW collected patients’ data and wrote the initial draft of the manuscript. ZZ provided CT analysis. JN and QC provided critical analysis and review of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Jing Ning.

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Ethics approval and consent to participate

The study protocol gained approval from the Ethics Committee of Zhengzhou Ninth People’s Hospital. This work was carried out following the Good Clinical Practice guidelines and the Declaration of Helsinki. This retrospective study did not require patient consent. All patient information was anonymous. The informed consent was waived from the Ethics Committee of Zhengzhou Ninth People’s Hospital.

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Not applicable.

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The authors declare no competing interests.

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Wang, H., Zhao, Z., Cao, Q. et al. A review of 17 cases of mesenteric panniculitis in Zhengzhou Ninth People’s Hospital in China. BMC Gastroenterol 24, 48 (2024). https://doi.org/10.1186/s12876-024-03136-8

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  • DOI: https://doi.org/10.1186/s12876-024-03136-8

Keywords

BMC Gastroenterology

ISSN: 1471-230X

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