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Health-related quality of life is related to the lactate level at ICU admission in brain traumatic injury and major trauma patients
Critical Care volume 13, Article number: P514 (2009)
Introduction
The aim of the study was to relate the health-related quality of life (HRQL) evaluated 6 months after major trauma and traumatic brain injury with the initial parameters of clinical picture and with the length of ICU stay and sedation. HQRL is reduced in ICU patients, admitted for any reason, after 6 months from discharge [1, 2]. The summarized Short-Form 36 (SF-36), comprehending physical functioning, general health, and social functioning, is useful to evaluate HQRL after major trauma [3].
Methods
One hundred and twenty-one patients were admitted to an emergency department ICU in 2007 with major trauma (injury severity score >15) and severe to moderate brain injury (Glasgow coma scale <13). Of these, 25 died in the days following trauma. Thirty-four of these were evaluated, during the follow-up visit, 6 months after discharge from the ICU. HRQL was assessed by the SF-36 questionnaire. At admission to the ICU, from the ICU database (FileMaker Pro 5.5v2; FileMaker, Inc., USA) with authorization of the Careggi Teaching Hospital Committee of the Emergency Department, the following parameters were collected for every patient: age, sex, abbreviated injury scale, injury severity score, Simplified Acute Physiology Score II, in the field Glasgow coma scale, Marshall score at the first head CT, worst values of lactates and ScvO2 within 24 hours from trauma. Also, the length of sedation and ICU stay were collected. The mean summarized SF-36 was related with the Pearson test to the other parameters.
Results
Only lactate levels showed a significant correlation with the mean summarized SF-36 (y = -0.0035x + 4.83; R = 0.59; P = 0.007).
Conclusion
In the patients affected by major trauma and brain traumatic injury, the HRQL appears to be related to the severity of the clinical picture on the first day of trauma assessed by lactate levels regardless of the length of ICU stay and sedation.
References
Hofhuis JG, et al.: The impact of critical illness on perceived health-related quality of life during ICU treatment, hospital stay, and after hospital discharge: a long-term follow-up study. Chest 2008, 133: 377-385. 10.1378/chest.07-1217
Hobrook TL, et al.: Outcome after major trauma: discharge and 6-month follow-up results from the Trauma Recovery Project. J Trauma 1998, 45: 315-323. 10.1097/00005373-199808000-00018
Andelic N, et al.: Functional outcome and health-related quality of life 10 years after moderate-to-severe traumatic brain injury. Acta Neurol Scand 2008, in press.
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Migliaccio, M., Di Filippo, A., Bonizzoli, M. et al. Health-related quality of life is related to the lactate level at ICU admission in brain traumatic injury and major trauma patients. Crit Care 13 (Suppl 1), P514 (2009). https://doi.org/10.1186/cc7678
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DOI: https://doi.org/10.1186/cc7678