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A Case of Glycogenic Cardiomegaly in a Dog

Ett fall av cardiomegalia glycogenica hos hund

Acta Veterinaria Scandinavica volume 11, pages 197–208 (1970)Cite this article

Abstract

A description is given of the macroscopic and microicopic picture of a rare entity of glycogenic cardiomegaly in a dog. Clinically it was diagnosed as a combination of tonsillitis, oesophageal dilatation and myocarditis. The characteristic symptoms were increasing difficulty in swallowing, sporadic vomiting, copious amount of mucus in the pharynx, unthriftiness and poor stale of nutrition.

The histochemical changes were characteristic, indicated a process of glycogenosis and conformed to the classic form of Pompe's disease. Beside the enormously hypertrophied heart, the process successively involved the brain, liver, lungs, oesophagus and kidneys. An interesting diagnostic pattern of glycogenosis was revealed in capillaries and in all arterial media.

The literature on glycogen storage disease is briefly reviewed and critically discussed with reference to the case presented.

Sammanfattning

Ett sällsynt fall av cardiomegalia glycogenica hos hund beskrives makro- och mikroskopiskt. Fallet diagnosticerades kliniskt som en kombination av tonsillit, eosofagusdilatation och myokardit. Karaktäristiska symtom var ökande sväljningssvårigheter, sporadiska kräkningar, slemansamling i svalget, apati och avmagring. Mikroskopiskt påvisades patologiska glykogenavlagringar överensstämmande med den klassiska formen av Pompes sjukdom. Förutom i det starkt förstorade hjärtat påvisades förändringar i hjärna, lever, lungor, matstrupe och njurar. Diagnostiskt intressanta glycogenavlagringar påvisades i kapillärerna och i median i alla artärer.

Litteraturen över glykogenoser genomgås kortfattat och diskuteras kritiskt med utgångspunkt från det framlagda fallet.

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Author notes

  1. I. Eldisoagi Mostafa

    Present address: Department of Veterinary Pathology, Uni-versity of Khartoum, P. 0. Box 32, Khartoum North, Sudan

Authors and Affiliations

  1. Department of Pathology, National Veterinary Institute, Stockholm, Sweden

    I. Eldisoagi Mostafa

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  1. I. Eldisoagi Mostafa
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Mostafa, I.E. A Case of Glycogenic Cardiomegaly in a Dog. Acta Vet Scand 11, 197–208 (1970). https://doi.org/10.1186/BF03547980

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Acta Veterinaria Scandinavica

ISSN: 1751-0147