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Use of Malathion Against Ectoparasites on Lactating Cows
Bruk au malation mot ektoparasitter på lakterende storfe
Acta Veterinaria Scandinavica volume 26, pages 352–362 (1985)
Abstract
The clinical effect, residues in milk and toxicological properties of a non-commercial formulation of malathion used as an ectoparasitic agent on cattle were investigated. The results show that the malathion preparation has a desired clinical effect. The maximum concentration of malathion in milk after topical application of 5 g malathion was 0.054 μg/ml 4–6 h post-treatment, and declined to 0.005 and 0.002 μg/ml 24 and 48 h post-treatment, respectively. Totally 0.006–0.03 % of the applied dose was excreted in the milk. No toxic effect, measured as inhibition of the cholinesterases in erythrocytes and plasma, could be detected after therapeutic use of malathion.
The pharmacokinetic evaluation after 2.5 g intravenous administration of malathion, indicated that the kinetics could probably be described by a multicompartment model.
Sammendrag
En undersøkelse av klinisk effekt, rester i melk og toksikologiske egenskaper til en ikke-kommersiell malationformulering, brukt som et ektoparasittmiddel på storfe, er utført. Resultatene viste at mialation i denne formuleringen har god effekt mot lus. Høyeste konsentrasjon av malation i melk, 0,054 μg/ml, ble funnet 4–6 timer etter dermal applikasjon av 5 g malation, og minsket til henholdsvis 0.005 μg/ml og 0,002 μg/ml 24 og 48 timer etter behandlingen. Totalt ble 0,006–0,03 % av applisert dose utskilt i melken.
Ingen toksisk effekt, målt som kolinesterasehemming i erytrocytter og plasma, kunne påvises etter en terapeutisk bruk av malation.
En farmakokinetisk vurdering etter intravenøs injeksjon av 2,5 g malation viste at malations disposisjon i organismen trolig kan beskrives ved en multi-compartment modell.
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Muan, B., Skåre, J.U., Søli, N.E. et al. Use of Malathion Against Ectoparasites on Lactating Cows. Acta Vet Scand 26, 352–362 (1985). https://doi.org/10.1186/BF03546535
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DOI: https://doi.org/10.1186/BF03546535