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EJNMMI Physics
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Volume 1 Supplement 1

Proceedings of the 3rd PSMR Conference on PET/MR and SPECT/MR

Combined MR-assisted motion and partial volume effects corrections – impact on PET data quantification

EJNMMI Physics volume 1, Article number: A38 (2014) Cite this article

Our goal in this study was to characterize the combined effect of MR-assisted motion correction (MC) and partial volume effects correction (PVEC) on the estimation of [11C]NNC112 binding potential (BP) in healthy volunteers.

29 subjects were scanned on the Siemens 3T MR-BrainPET scanner prototype. Emission data were acquired in list mode format for 90-minutes following the i.v. administration of ~8 mCi of [11C]NNC112. The head attenuation map was obtained from the MPRAGE data using an atlas-based method. Head motion estimates were derived from the MR data and used to correct the PET data in LOR space before image reconstruction [1]. PVEC was applied to the motion corrected data using the region-based voxel-wise (RBV) method [2] and regions of interest (ROIs) defined from the MPRAGE images using FreeSurfer and the measured point-spread function [3]. BPnd for each of the ROIs was estimated in PMOD using the simplified reference tissue kinetic (SRTM) model and the cerebellum as a reference tissue.

Maximum translations of up to 9 mm and rotations of up to 12 degrees have been observed in this group of subjects (Figure 1). Less variability in the tissue time activity curves (TACs) was noted after MC (the curves before and after MC for a representative subject are shown in Figure 2). The percentage changes in BPnd after MC and PVEC revealed both under- and overestimation in the ROIs analyzed (Figure 3). The cumulative effect exceeded 100% for some of the structures analyzed.

Figure 1
figure 1

Maximum translations (left) and rotations (right) measured in 29 healthy volunteers scanned for 90 minutes

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Figure 2
figure 2

TACs in the left and right caudate and cerebellar cortices before (left) and after (right) MR-assisted motion correction

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Figure 3
figure 3

Percent change in NNC112 BPnd after motion and partial volume effects corrections

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Significant motion and PVE were observed in all the subjects, biasing the PET estimates. The combined effect is difficult to predict, depending on the size and location of the structure of interest and patient compliance. Without addressing these issues, the value of the BPnd’s derived from these data is questionable.

References

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Authors and Affiliations

  1. Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA

    Ciprian Catana, Daniel B Chonde, Kevin T Chen, David Izquierdo-Garcia, Spencer Bowen, Jacob Hooker & Joshua Roffman

  2. Program in Biophysics, Harvard University, Cambridge, MA, USA

    Daniel B Chonde

  3. Department of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Daniel B Chonde & Kevin T Chen

  4. Psychiatry Department, Massachusetts General Hospital, MA, USA

    Joshua Roffman

Authors
  1. Ciprian Catana
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  2. Daniel B Chonde
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  3. Kevin T Chen
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  4. David Izquierdo-Garcia
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  5. Spencer Bowen
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  6. Jacob Hooker
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  7. Joshua Roffman
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0), which permits use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Catana, C., Chonde, D.B., Chen, K.T. et al. Combined MR-assisted motion and partial volume effects corrections – impact on PET data quantification. EJNMMI Phys 1 (Suppl 1), A38 (2014). https://doi.org/10.1186/2197-7364-1-S1-A38

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  • DOI: https://doi.org/10.1186/2197-7364-1-S1-A38

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