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J Brachial Plex Peripher Nerve Inj 2008; 03(01): e136-e140
DOI: 10.1186/1749-7221-3-6
Review
Sughrue et al; licensee BioMed Central Ltd.

Pain as a symptom of peripheral nerve sheath tumors: clinical significance and future therapeutic directions[*]

Michael E Sughrue
1   Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, California, USA
,
Jon Levine
2   Department of Medicine, University of California at San Francisco, 505 Parnassus Ave, San Francisco, California, USA
,
Nicholas M Barbaro
1   Department of Neurological Surgery, University of California at San Francisco, 505 Parnassus Ave, San Francisco, California, USA
› Author Affiliations
Subject Editor:
Further Information

Publication History

24 October 2007

29 February 2008

Publication Date:
17 September 2014 (online)

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Abstract

Tumors arising from the supporting cells of peripheral nerve sheaths are relatively uncommon neoplasms, and as such many clinicians are unfamiliar with the details of their presentation, diagnosis and management. Further, little is known regarding the pathogenesis of these tumors, how they cause symptoms, and how to treat these symptoms. One classic symptom of peripheral nerve tumors is pain, however there has been little formal discussion regarding the significance of pain in this setting. Here we present a brief review of the clinical significance of pain, its relevance in pre-operative planning for the treatment of these tumors, and what is known regarding the molecular mechanisms of pain generation by these tumors.

*This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


 

  • References

  • 1 Ogose A, Hotta T, Morita T, Yamamura S, Hosaka N, Kobayashi H, Hirata Y. Tumors of peripheral nerves: correlation of symptoms, clinical signs, imaging features, and histologic diagnosis. Skeletal radiology 1999; 28 (4) 183-188 10.1007/s002560050498 10384987
    CrossrefPubMedGoogle Scholar
  • 2 Kim DH, Murovic JA, Tiel RL, Kline DG. Operative outcomes of 546 Louisiana State University Health Sciences Center peripheral nerve tumors. Neurosurgery clinics of North America 2004; 15 (2) 177-192 10.1016/j.nec.2004.02.006 15177317
    CrossrefPubMedGoogle Scholar
  • 3 Valeyrie-Allanore L, Ismaili N, Bastuji-Garin S, Zeller J, Wechsler J, Revuz J, Wolkenstein P. Symptoms associated with malignancy of peripheral nerve sheath tumours: a retrospective study of 69 patients with neurofibromatosis 1. The British journal of dermatology 2005; 153 (1) 79-82 10.1111/j.1365-2133.2005.06558.x 16029330
    CrossrefPubMedGoogle Scholar
  • 4 Kim DH, Murovic JA, Tiel RL, Kline DG. Management and outcomes in 318 operative common peroneal nerve lesions at the Louisiana State University Health Sciences Center. Neurosurgery 2004; 54 (6) 1421-8; discussion 1428-9 10.1227/01.NEU.0000124752.40412.03 15157299
    CrossrefPubMedGoogle Scholar
  • 5 Fein DA, Lee WR, Lanciano RM, Corn BW, Herbert SH, Hanlon AL, Hoffman JP, Eisenberg BL, Coia LR. Management of extremity soft tissue sarcomas with limb-sparing surgery and postoperative irradiation: do total dose, overall treatment time, and the surgery-radiotherapy interval impact on local control?. International journal of radiation oncology, biology, physics 1995; 32 (4) 969-976 7607971
    CrossrefPubMedGoogle Scholar
  • 6 Leroy K, Dumas V, Martin-Garcia N, Falzone MC, Voisin MC, Wechsler J, Revuz J, Creange A, Levy E, Lantieri L, Zeller J, Wolkenstein P. Malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1: a clinicopathologic and molecular study of 17 patients. Archives of dermatology 2001; 137 (7) 908-913 11453810
    PubMedGoogle Scholar
  • 7 Mundt AJ, Awan A, Sibley GS, Simon M, Rubin SJ, Samuels B, Wong W, Beckett M, Vijayakumar S, Weichselbaum RR. Conservative surgery and adjuvant radiation therapy in the management of adult soft tissue sarcoma of the extremities: clinical and radiobiological results. International journal of radiation oncology, biology, physics 1995; 32 (4) 977-985 7607972
    CrossrefPubMedGoogle Scholar
  • 8 Devor M, Govrin-Lippmann R, Angelides K. Na+ channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation. J Neurosci 1993; 13 (5) 1976-1992 7683047
    PubMedGoogle Scholar
  • 9 Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, Porreca F, Lai J. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J Neurosci 2003; 23 (1) 158-166 12514212
    PubMedGoogle Scholar
  • 10 Koschorke GM, Meyer RA, Tillman DB, Campbell JN. Ectopic excitability of injured nerves in monkey: entrained responses to vibratory stimuli. Journal of neurophysiology 1991; 65 (3) 693-701 1711106
    PubMedGoogle Scholar
  • 11 Michaelis M, Blenk KH, Vogel C, Janig W. Distribution of sensory properties among axotomized cutaneous C-fibres in adult rats. Neuroscience 1999; 94 (1) 7-10 10.1016/S0306-4522(99)00325-5 10613490
    CrossrefPubMedGoogle Scholar
  • 12 Coward K, Plumpton C, Facer P, Birch R, Carlstedt T, Tate S, Bountra C, Anand P. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain 2000; 85 (1-2) 41-50 10.1016/S0304-3959(99)00251-1 10692601
    CrossrefPubMedGoogle Scholar
  • 13 Yiangou Y, Birch R, Sangameswaran L, Eglen R, Anand P. SNS/PN3 and SNS2/NaN sodium channel-like immunoreactivity in human adult and neonate injured sensory nerves. FEBS letters 2000; 467 (2-3) 249-252 10.1016/S0014-5793(00)01166-2 10675548
    CrossrefPubMedGoogle Scholar
  • 14 Yiangou Y, Facer P, Birch R, Sangameswaran L, Eglen R, Anand P. P2X3 receptor in injured human sensory neurons. Neuroreport 2000; 11 (5) 993-996 10.1097/00001756-200004070-00019 10790870
    CrossrefPubMedGoogle Scholar
  • 15 Roza C, Laird JM, Souslova V, Wood JN, Cervero F. The tetrodotoxin-resistant Na+ channel Nav1.8 is essential for the expression of spontaneous activity in damaged sensory axons of mice. The Journal of physiology 2003; 550 (Pt 3) 921-926 10.1113/jphysiol.2003.046110 12824446
    CrossrefPubMedGoogle Scholar
  • 16 Sevcik MA, Ghilardi JR, Peters CM, Lindsay TH, Halvorson KG, Jonas BM, Kubota K, Kuskowski MA, Boustany L, Shelton DL, Mantyh PW. Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization. Pain 2005; 115 (1-2) 128-141 10.1016/j.pain.2005.02.022 15836976
    CrossrefPubMedGoogle Scholar
  • 17 Wacnik PW, Baker CM, Herron MJ, Kren BT, Blazar BR, Wilcox GL, Hordinsky MK, Beitz AJ, Ericson ME. Tumor-induced mechanical hyperalgesia involves CGRP receptors and altered innervation and vascularization of DsRed2 fluorescent hindpaw tumors. Pain 2005; 115 (1-2) 95-106 10.1016/j.pain.2005.02.024 15836973
    CrossrefPubMedGoogle Scholar
  • 18 Zhu Z, Friess H, diMola FF, Zimmermann A, Graber HU, Korc M, Buchler MW. Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer. J Clin Oncol 1999; 17 (8) 2419-2428 10561305
    CrossrefPubMedGoogle Scholar
  • 19 Wacnik PW, Eikmeier LJ, Ruggles TR, Ramnaraine ML, Walcheck BK, Beitz AJ, Wilcox GL. Functional interactions between tumor and peripheral nerve: morphology, algogen identification, and behavioral characterization of a new murine model of cancer pain. J Neurosci 2001; 21 (23) 9355-9366 11717369
    PubMedGoogle Scholar
  • 20 Lee PR, Cohen JE, Tendi EA, Farrer R, GH DEV, Becker KG, Fields RD. Transcriptional profiling in an MPNST-derived cell line and normal human Schwann cells. Neuron Glia Biol 2004; 1 (2) 135-147 1325299 16429615 10.1017/S1740925X04000274
    CrossrefPubMedGoogle Scholar
  • 21 Halvorson KG, Kubota K, Sevcik MA, Lindsay TH, Sotillo JE, Ghilardi JR, Rosol TJ, Boustany L, Shelton DL, Mantyh PW. A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone. Cancer research 2005; 65 (20) 9426-9435 10.1158/0008-5472.CAN-05-0826 16230406
    CrossrefPubMedGoogle Scholar
  • 22 Anand P. Neurotrophic factors and their receptors in human sensory neuropathies. Progress in brain research 2004; 146: 477-492 14699981
    PubMedGoogle Scholar
  • 23 Kitamura N, Konno A, Kuwahara T, Komagiri Y. Nerve growth factor-induced hyperexcitability of rat sensory neuron in culture. Biomedical research (Tokyo, Japan) 2005; 26 (3) 123-130 16011305
    CrossrefPubMedGoogle Scholar
  • 24 Werrbach-Perez K, Perez-Polo JR. De novo synthesis of NGF subunits in S-180 mouse sarcoma cell line. Neurochemical research 1987; 12 (10) 875-883 10.1007/BF00966309 3683737
    CrossrefPubMedGoogle Scholar
  • 25 Cohen S, Levi-Montalcini R, Hamburger V. A Nerve Growth-Stimulating Factor Isolated from Sarcom as 37 and 180. Proceedings of the National Academy of Sciences of the United States of America 1954; 40 (10) 1014-1018 534215 16589582 10.1073/pnas.40.10.1014
    CrossrefPubMedGoogle Scholar
  • 26 Levi-Montalcini R, Meyer H, Hamburger V. In vitro experiments on the effects of mouse sarcomas 180 and 37 on the spinal and sympathetic ganglia of the chick embryo. Cancer research 1954; 14 (1) 49-57 13126933
    PubMedGoogle Scholar
  • 27 Wagner R, Myers RR. Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves. Neuroscience 1996; 73 (3) 625-629 10.1016/0306-4522(96)00127-3 8809782
    CrossrefPubMedGoogle Scholar
  • 28 Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport 1996; 7 (18) 2897-2901 10.1097/00001756-199611250-00018 9116205
    CrossrefPubMedGoogle Scholar
  • 29 Chattopadhyay S, Myers RR, Janes J, Shubayev V. Cytokine regulation of MMP-9 in peripheral glia: Implications for pathological processes and pain in injured nerve. Brain Behav Immun 2006; 17189680
    PubMedGoogle Scholar
  • 30 Takahashi M, Kawaguchi M, Shimada K, Konishi N, Furuya H, Nakashima T. Cyclooxygenase-2 expression in Schwann cells and macrophages in the sciatic nerve after single spinal nerve injury in rats. Neuroscience letters 2004; 363 (3) 203-206 10.1016/j.neulet.2004.03.040 15182944
    CrossrefPubMedGoogle Scholar
  • 31 Bhangoo SK, Ren D, Miller RJ, Chan DM, Ripsch MS, Weiss C, McGinnis C, White FA. CXCR4 chemokine receptor signaling mediates pain hypersensitivity in association with antiretroviral toxic neuropathy. Brain Behav Immun 2007; 2062574 17292584
    PubMedGoogle Scholar
  • 32 Abbadie C, Lindia JA, Cumiskey AM, Peterson LB, Mudgett JS, Bayne EK, DeMartino JA, MacIntyre DE, Forrest MJ. Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proceedings of the National Academy of Sciences of the United States of America 2003; 100 (13) 7947-7952 164693 12808141 10.1073/pnas.1331358100
    CrossrefPubMedGoogle Scholar
  • 33 Koltzenburg M, Scadding J. Neuropathic pain. Current opinion in neurology 2001; 14 (5) 641-647 10.1097/00019052-200110000-00014 11562577
    CrossrefPubMedGoogle Scholar
  • 34 Tyner TR, Parks N, Faria S, Simons M, Stapp B, Curtis B, Sian K, Yamaguchi KT. Effects of collagen nerve guide on neuroma formation and neuropathic pain in a rat model. American journal of surgery 2007; 193 (1) e1-6 10.1016/j.amjsurg.2006.08.026 17188077
    CrossrefPubMedGoogle Scholar