Chinese Journal of Minimally Invasive Neurosurgery. 2016, (06)

Concurrent gamma knife radiosu rgery and bevacizumab treatment for brain metastasis from colorectal cancer with extensive cerebral edema:5 cases reportChinese Full Text

Tang Xuqun;Jiang Hua;Wei Lichen;Zhang Nan;Dai Jiazhong;Wu Hanfeng;Pan Li;Department of Neurosurgery, Shanghai Gamma Hospital, Gamma Knife Centre of Huashan Hospital, Fudan University;

Abstract: Objective To explore the efficacy and safety of concurrent gamma knife radiosurgery and bevacizumab treatment for brain metastasis from colorectal cancer with extensive cerebral edema. Methods Five patients with brain metastasis from colorectal cancer were included in this prospective investigation from March 2013 to October 2014. Bevacizumab therapy（5 mg/kg, at 2 to 3 week intervals） was administered the next day after completion of gamma knife radiosurgery for the median treatment cycle of 4. The patients were followed up for median period of 13 months, ranged from 7 to 18 months. Results Compared with the pretreatment, the lesions decreased by median of 42.85%, ranged from 29.51% to 100% on enhanced MRI T₁WI sequence, and edema area decreased by median of 86.60%, ranged from 69.03% to 97.51% on T₂WI sequence during short-term follow-up period after the treatment. Clinical symptoms were improved in all the 5 patients, and the KPS increased by a median of 30, ranged from 20 to 40 scores. At last follow-up, two patients died, one progressed and the other two kept tumor progression free. No symptomatic radiation or severe bevacizumab-related adverse events occurred. Conclusion Coadministration of gamma knife radiosurgery and bevacizumab as a promising salvage treatment is safe and effective for brain metastasis from colorectal cancer with extensive cerebral edema.

Keywords：

metastatic brain tumor; colorectal cancer; stereotaetic radiosurgery; gamma knife; bevacizumab; cerebral edema;

Series：
(E) Medicine ＆ Public Health
Subject：
Oncology
Classification Code：
R735.34

Mobile Reading

Read on your phone instantly

Step 1
Scan QR Codes

"Mobile CNKI-CNKI Express" App

Step 2
Open“CNKI Express”

and click the scan icon in the upper left corner of the homepage.

Step 3
Scan QR Codes

Read this article on your phone.
HTML
CAJ Download
PDF Download

Contents

Concurrent gamma knife radiosu rgery and bevacizumab treatment for brain metastasis from colorectal cancer with extensive cerebral edema:5 cases reportChinese Full Text

Tang Xuqun;Jiang Hua;Wei Lichen;Zhang Nan;Dai Jiazhong;Wu Hanfeng;Pan Li;Department of Neurosurgery, Shanghai Gamma Hospital, Gamma Knife Centre of Huashan Hospital, Fudan University;

Read on your phone instantly

Citation Network

Related Literature