Abstract: Objective To study main driver-related risk factors of road traffic injury in China and to provide evidences for decision-making on road traffic injury prevention.Methods A computerized online search was conducted in China National Knowledge Infrastructure,Wanfang Database,SinoMed,Web of Science,Google Scholar,PubMed and related websites to collect articles(published between 2000 and 2012) with the keywords of road traffic injury,injury,road traffic accident,crash,vehicle,risk factor,case-control study,and case-crossover study.A total of 713 papers were collected.Stata 12.0 software was adopted in the meta-analysis,and combined odds ratio(OR) and 95% confidence interval(95%CI) were calculated to evaluate driver-related risk for road traffic injuries.Results Finally 14 studies were included in the study.The cumulative cases and controls were 3 161 and 4 450,respectively.The results showed that the driver-related risk factors(OR,95%CI) for road traffic injuries were carelessness(19.25,9.16-40.48),wrong judgment(15.62,9.65-25.29),violating the rules of giving the way(15.10,7.47-30.53),taking wrong management(11.23,5.96-21.18),not doing necessary repair for the vehicle(9.34,3.01-28.94),drunk drinking(6.30,2.64-15.02),overloading(5.65,3.40-9.40),with history of road accident(4.05,2.95-5.56),education background(3.85,1.91-7.74),fatigue driving(3.46,2.51-4.77),with experience of running the red light when driving(1.86,1.51-2.28),and over-speed driving(1.30,1.13-1.50).Conclusion The main driver-related risk factors of road traffic injuries in China are carelessness,wrong judgment,violating the rules of giving the way,and not doing necessary repair for the vehicle and intervention on those driver-related factors may reduce the risk of road traffic injury.