Abstract: Objective To investigate the association between interleukin-10(IL-10) promoter polymorphism and environmental factors in hereditary susceptibility to hepatocellular carcinoma.Methods A hospital based case control study was conducted in 589 cases with hepa to cellular care icnona(HCC) and 597 controls with diseases other than tumor.IL-10 promoter single nucleotide polymorphism (SNP) was determined by real-time polymorphism chain reaction with TaqMan MGB probe.Unconditional logistic regression was used to estmiate the oddsratios and 95 confidence intervals.Results For the genotypes of IL-10 on-819 and-592 site, there was nosignificant difference between cases and controls(P> 0.05).The genotypes of IL-10 were not associated with hepatocellular carcinoma.But the interaction of cytokine IL-10 promoter polymorphism and environmental factors was associated with hereditary susceptibility to hepatocellular carcinoma.Conclusion The SNPs of IL-10 on-819 and-592 site do not increase the risk of hepatocellular carcinoma them selves, but increase the risk of hepato cellular carcinoma together with environmental factors including smoking, alcohol drinking, eating uncooked fish, and hepatitis B virus infection.