Objective  To explore the association of 5-hydroxytryptamine 2A receptor (5-HT2AR) and 5-hydroxytryptamine 2C receptor (5-HT2CR) genes with sleep disorder among depression patients.

  Methods  A total of 275 unipolar depression outpatients with sleep disorder were recruited in the Psychiatry Department of First Affiliated Hospital of Harbin Medical University and 300 gender- and age-matched healthy persons taking physical examination at the hospital and during the same period were selected between September 2014 and June 2016 in Harbin city of Heilongjiang province. The DNA of all the participants were extracted and genotype distributions of 5-HT2AR rs6315 and 5-HT2CR rs518147 genes were detected with single base extension single nucleotide polymorphism (SNP) typing technique. Chi-square test and binary logistic regression were performed with SPSS 18.0.

  Results  The proportions of cases with 5-HT2AR rs6315 genotype of AA, AG, and GG were 74.5.0% (205/275), 12.7% (35/275), and 12.7% (35/275) and those of the controls were 83.7% (251/300), 5% (15/300), and 11.3% (34/300), respectively; the proportions of cases with 5-HT2AR rs6315 allele of A and G were 80.9% (445/550) and 19.1% (105/550) and those of the controls were 86.2% (517/600) and 13.8% (83/600). There were significant differences in the genotype and allele frequency distribution of 5-HT2AR rs6315 between the cases and the controls (P < 0.05 for all); but no significant differences were observed in the genotype and allele frequency distribution of 5-HT2CR rs518147 between the cases and the controls (P > 0.05 for all). There were no interactions between genes of 5-HT2AR rs6315 and 5-HT2CR rs518147 among both the cases and the controls and there was no significant difference in the interaction of the two genes between the cases and the controls (P > 0.05).

  Conclusion  5-HT2AR rs6315 and 5-HT2CR rs518147 genes are not significantly correlated with sleep disorder among depression patients.