Abstract
Background: BEx are important events in the natural history of bronchiectasis.
Objective: This study explored the longitudinal association between the number of BEx at baseline and over 4 y of follow-up.
Methods: We used data from adult patients with non–cystic fibrosis bronchiectasis (NCFBE) and 4 y of follow-up (2008-2020) in the BRR database. Analyses were performed at 3 time points in 2-y intervals: baseline (≤2 y prior to enrollment), Y1+2, and Y3+4. Patients were stratified by number of BEx at each time point: 0, 1, or ≥2.
Results: A total of 520 patients (mean age, 65.2 y; 84% female; BE duration, 8.0 y) were included. At baseline 41%, 23%, and 36% of patients had 0, 1, and ≥2 BEx, respectively. The groups differed (P<0.05) in age, BE duration, nontuberculous mycobacteria and P aeruginosa status, FEV1, and asthma. A statistically significant association was found between BEx at baseline and Y1+2, baseline and Y3+4, and Y1+2 and Y3+4 (P<0.0001) (Figure); a greater number of baseline BEx was associated with a greater number of follow-up BEx; the group with ≥2 BEx at baseline had the most BEx over the 4-y follow-up.
Conclusion: A greater number of exacerbations at baseline was positively associated with a greater number of exacerbations at follow-up, highlighting exacerbation prevention as an important unmet need in patients with NCFBE.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 1858.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
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