Skip to main content

Advertisement

SpringerLink
Log in

Neonatal Morbidity and Mortality in Intrauterine Growth Restricted (IUGR) Pregnancies Is Predicated Upon Prenatal Diagnosis of Clinical Severity

  • Published:
Reproductive Sciences Aims and scope Submit manuscript

Abstract

The objective of this work was to determine whether the prenatal determinates of clinical severity in intrauterine growth restricted pregnancies, established by abdominal circumference measures, correlates with neonatal morbidity and mortality. A total of 336 singleton pregnancies with intrauterine growth restriction were subdivided into group 1 (normal fetal heart rate and pulsatility index of the umbilical artery: 251 cases), group 2 (normal fetal heart rate and abnormal pulsatility index: 50 cases), and group 3 (abnormal fetal heart rate and pulsatility index: 35 cases). Gestational age, birth weight, body mass index, placental weight, and Apgar score were significantly related to the severity of intrauterine growth restriction (P < .001). Neonatal survival was 100%, 96%, and 57% in the 3 groups, respectively (P < .001). Greater than 80% of neonates of group 1 had no complications when compared to group 2 (54%) and group 3 (10%); P < .001. Gestational age was the only independent variable significantly associated with neonatal outcomes. The data confirm that the classification of clinical severity of intrauterine growth restriction based on biophysical parameters is clinically relevant to predict neonatal outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Garite TJ, Clark R, Thorp JA. Intrauterine growth restriction increases morbidity and 310 mortality among premature neo-nates. Am J Obstet Gynecol. 2004;191:481–7.

    Article  Google Scholar 

  2. Khoury MJ, Erickson D, Cordero JE, McCarthy BJ. Congenital malformations and intrauterine growth retardation: a population study. Pediatrics. 1988;82:83–90.

    CAS  PubMed  Google Scholar 

  3. Barker DJ. The developmental origins of chronic adult disease. Acta Paediatr Suppl. 2004;93:26–33.

    Article  CAS  Google Scholar 

  4. Pardi G, Cetin I, Marconi AM, et al. Diagnostic value of blood sampling in fetuses with growth retardation. N Engl J Med. 1993;328:692–696.

    Article  CAS  Google Scholar 

  5. Marconi AM, Paolini CL, Stramare L, et al. Steady state maternal-fetal leucine enrichments in normal and intrauterina growth restricted pregnancies. Pediatr Res. 1999;46:114–119.

    Article  CAS  Google Scholar 

  6. Marconi AM, Paolini C, Buscaglia M, Zerbe G, Battaglia FC, Pardi G. The impact of gestational age and fetal growth on the maternal-fetal glucose concentration difference. Obstet Gynecol. 1996;87:937–942.

    Article  CAS  Google Scholar 

  7. Ferrazzi E, Bozzo M, Rigano S, et al. Temporal sequence of abnormal Doppler changes in the peripheral and central circulatory systems of the severely growth-restricted fetus. Ultrasound Obstet Gynecol. 2002;19:140–146.

    Article  CAS  Google Scholar 

  8. Todros T, Ferrazzi E, Groli C, et al. Fitting growth curves to head and abdomen measurements of the fetus: a multicentric study. J Clin Ultrasound. 1997;15:95–105.

    Article  Google Scholar 

  9. Parazzini F, Cortinovis I, Bortolus R, Fedele L. Standard di peso alla nascita in Italia. Ann Ost Gin Med Perin. 1991;CXII:203–246.

  10. Ferrazzi E, Gementi P, Bellotti M, et al. Doppler velocime-try: critical analysis of umbilical, cerebral and aortic reference values. Eur J Obstet Gynecol Reprod Biol. 1991;38:189–196.

    Article  CAS  Google Scholar 

  11. Berkowitz GS, Skovron ML, Lapinski RH, Berkowitz RL. Delayed childbearing and the outcome of pregnancy. N Engl J Med. 1990;322:693–694.

    Article  Google Scholar 

  12. Prysak M, Lorentz RP, Kisly A. Pregnancy outcome in nulliparous women 35 years and older. Obstet Gynecol. 1995;85:65–70.

    Article  CAS  Google Scholar 

  13. Sibai B, Dekker G, Kupferminc M. Pre-eclampsia. Lancet. 2005;365:785–799.

    Article  Google Scholar 

  14. Simchen MJ, Beiner ME, Strauss-Liviathan N, et al. Neonatal outcome in growth-restricted versus appropriately grown pre-term infants. Am J Perinatol. 2000;17:187–192.

    Article  CAS  Google Scholar 

  15. Bernstein IM, Horbar JD, Badger GJ, Ohlsson A, Golan A. Morbidity and mortality among very-low-birth-weight neo-nates with intrauterine growth restriction. Am J Obstet Gynecol. 2000;182:198–206.

    Article  CAS  Google Scholar 

  16. Baschat AA, Cosmi E, Bilardo CM, et al. Predictors of neonatal outcome in early-onset placental dysfunction. Obstet Gynecol. 2007;109:253–261.

    Article  Google Scholar 

  17. Baschat AA. Doppler application in the delivery timing of the preterm growth-restricted fetus: another step in the right direction. Ultrasound Obstet Gynecol. 2004;23:111–118.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Department of Statistics, DMSD San Paolo, University of Milano, Via A. di Rudinș 8, 20142, Milano, Italy

    Anna Maria Marconi MD, Stefania Ronzoni MD, Simona Vailati MD, Patrizia Bozzetti MD & Alberto Morabito MD

  2. Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, Italy

    Frederick C. Battaglia MD

Authors
  1. Anna Maria Marconi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefania Ronzoni MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Simona Vailati MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Patrizia Bozzetti MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alberto Morabito MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Frederick C. Battaglia MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Anna Maria Marconi MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Marconi, A.M., Ronzoni, S., Vailati, S. et al. Neonatal Morbidity and Mortality in Intrauterine Growth Restricted (IUGR) Pregnancies Is Predicated Upon Prenatal Diagnosis of Clinical Severity. Reprod. Sci. 16, 373–379 (2009). https://doi.org/10.1177/1933719108327591

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1177/1933719108327591

Key words

Search

Navigation