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Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy

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Abstract

Our aim was to determine whether placental A Disintegrin-like Metalloproteinase with ThromboSpondin motif 12 (ADAMTS-12), arylesterase (ARES) levels, total oxidant status (TOS), and total antioxidant status (TAS) differ in preeclampsia, intrahepatic cholestasis of pregnancy (ICP), and uncomplicated pregnancies or not. A prospective case–control study was carried out including 84 pregnant women (26 with ICP, 28 preeclamptic patients, and 30 healthy controls). Levels of ADAMTS-12, TAS, TOS, and ARES were studied in the supernatants of placental tissue homogenates. Placental ADAMTS-12 levels were distributed as 240.9 pg/mg in ICP, 289.7 pg/mg in preeclampsia, and 310.8 pg/mg in control groups. Levels of ADAMTS-12 (odds ratio = 6.509, 95% confidence interval:1.070-39.592, P = .042) in the placenta of the ICP were significantly lower than those in preeclampsia and control groups (P = .004), but no statistical significant difference was determined between preeclampsia and control groups. Decreased levels of placental ADAMTS-12 were found to be associated with ICP, suggesting a possible role of inflammation in the pathogenesis.

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Authors and Affiliations

  1. Department of Perinatology, Zekai Tahir Burak Women’s Health Education and Research Hospital, Talatpasa Street, 06230, Ankara, Samanpazarı, Turkey

    Efser Oztas MD, Sibel Ozler MD, Ali O. Ersoy MD, Kudret Erkenekli MD, Ayhan Sucak MD, Dilek Uygur MD & Nuri Danisman MD

  2. Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

    Merve Ergin MD

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  1. Efser Oztas MD
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  2. Sibel Ozler MD
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  3. Ali O. Ersoy MD
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Correspondence to Efser Oztas MD.

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Oztas, E., Ozler, S., Ersoy, A.O. et al. Placental ADAMTS-12 Levels in the Pathogenesis of Preeclampsia and Intrahepatic Cholestasis of Pregnancy. Reprod. Sci. 23, 475–481 (2016). https://doi.org/10.1177/1933719115604730

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