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Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues

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Abstract

This study investigates the influence of ovarian endometrioma on expression of steroid receptor RNA activator (SRA), estrogen receptors (ERs), vascular endothelial growth factor (VEGF), and thrombospondin 1 (TSP-1) in the surrounding ovarian tissues. Taken from the women with ovarian endometrioma and mature teratoma during laparoscopy, the biopsies were analyzed by real-time polymerase chain reaction and Western blot. Our results indicated that ovarian tissues surrounding endometrioma had lower SRA and ER-α levels but higher SRA protein (SRAP) and ER-β levels than ovarian endometrioma. With lower VEGF levels and higher TSP-1 levels, the surrounding ovarian tissues showed higher expression levels of SRA, SRAP, ER-α, and ER-β in the ovarian endometrioma group when compared to the controls. These data showed that ovarian endometrioma increases SRA, ERs, and TSP-1 but decreases VEGF levels in the surrounding ovarian tissues, suggesting that abnormal expression of these molecules may affect biological behaviors of ovarian endometrioma.

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Authors and Affiliations

  1. Department of Gynecology, Women’s Hospital, Zhejiang University School of Medicine, 2 Xueshi Road, 310006, Hangzhou, Zhejiang, People’s Republic of China

    Kaiqing Lin MD, Ruijin Wu MD & Jun Lin MD

  2. Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, People’s Republic of China

    Junyan Ma MD

  3. Department of Pathology, Women’s Hospital, Zhejiang University School of Medicine, Zhejiang, People’s Republic of China

    Caiyun Zhou MD

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  1. Kaiqing Lin MD
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  2. Junyan Ma MD
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  4. Caiyun Zhou MD
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  5. Jun Lin MD
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Correspondence to Jun Lin MD.

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Lin, K., Ma, J., Wu, R. et al. Influence of Ovarian Endometrioma on Expression of Steroid Receptor RNA Activator, Estrogen Receptors, Vascular Endothelial Growth Factor, and Thrombospondin 1 in the Surrounding Ovarian Tissues. Reprod. Sci. 21, 183–189 (2014). https://doi.org/10.1177/1933719113492205

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