Studies of Silk Fibroin/Poly(Lactic-Co-Glycolic Acid) Scaffold, Prepared by Thermally Induced Phase Separation, as a Possible Wound Dressing
Silk fibroin (SF), with the excellent biocompatibility, was combined with poly(lactic-co-glycolic acid) (PLGA) to produce scaffolds with the ability to mimic the extracellular matrix (ECM). In this work, scaffolds with different weight ratios of SF/PLGA (8/8, 5/8, 2/8) were prepared
by thermally induced phase separation (TIPS), and their characteristics as wound dressings were investigated. The results of water vapor permeability, water uptake rate and water loss rate showed that the optimal weight ratio of SF/PLGA was 8/8, which could absorb wound skin exudates to prevent
infection and maintain wound humidity. The water vapor transmission rate was 5591.88 ± 56.70 g/m2/day, and the maximum equilibrium water uptake rate was 72.2%. Furthermore, the curcumin release results showed that the scaffolds had sustained release properties, which indicated
that the SF/PLGA scaffold prepared by TIPS could be used in wound dressing with additional functionalities.
Keywords: CURCUMIN; PLGA; SILK FIBROIN; THERMAL INDUCED PHASE SEPARATION; WOUND DRESSING
Document Type: Research Article
Publication date: 01 May 2016
- Science of Advanced Materials (SAM) is an interdisciplinary peer-reviewed journal consolidating research activities in all aspects of advanced materials in the fields of science, engineering and medicine into a single and unique reference source. SAM provides the means for materials scientists, chemists, physicists, biologists, engineers, ceramicists, metallurgists, theoreticians and technocrats to publish original research articles as reviews with author's photo and short biography, full research articles and communications of important new scientific and technological findings, encompassing the fundamental and applied research in all latest aspects of advanced materials.
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