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Thromb Haemost 2007; 98(02): 413-419
DOI: 10.1160/TH06-10-0561
Cardiovascular Biology and Cell Signalling
Schattauer GmbH

Evaluation of antibodies to oxidized low-density lipoprotein and assessment of C-reactive protein in acute coronary syndrome and stable coronary artery disease

Pal Soltesz
1   Intensive Care Unit and
,
Katalin Veres
1   Intensive Care Unit and
,
Renata Laczik
1   Intensive Care Unit and
,
Henrietta Der
1   Intensive Care Unit and
,
Istvan Csipo
2   Regional Immune Laboratory, University of Debrecen, Medical and Health Science Center, Institute for Internal Medicine, 3rd Department of Medicine; Debrecen, Hungary
,
Orsolya Timar
1   Intensive Care Unit and
,
Edit Szomjak
1   Intensive Care Unit and
,
Gyula Szegedi
1   Intensive Care Unit and
,
Peter Szodoray
1   Intensive Care Unit and
› Author Affiliations Financial support:This study was supported by grants from the Hungarian National Research Fund (OTKA T 46517) and János Bolyai research fellow competition.
Further Information

Publication History

Received 04 October 2006

Accepted after resubmission 17 May 2007

Publication Date:
28 November 2017 (online)

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Summary

The aim was to measure the level of antibodies to oxidized LDL (oxLDL) and C-reactive protein (CRP) in the serum of patients with acute coronary syndrome (ACS). The results were correlated with data obtained from patients with stable coronary artery disease (stable CAD) and healthy controls.Thirty-three patients with ACS and 62 stable CAD patients were enrolled in the study. Fifty healthy individuals served as controls.The evaluation of anti-oxLDL autoantibodies was performed by ELISA, while CRP levels were measured by turbidimetry. The level of antibodies to oxLDL was significantly higher in both groups of patients with ACS and stable CAD compared to controls.The comparison between the acute and stable groups showed that anti-oxLDL levels were higher in the acute group,but because of high SD, the difference was not significant. By performing group analysis, anti-oxLDL levels were found to be significantly higher in ACS patients with unstable clinical state (circulatory insufficiency, malignant arrhythmias, recurring ischemic pain, need for urgent coronary intervention and death). CRP level in patients with ACS was significantly higher than in those with stable CAD. A positive correlation was found between anti-oxLDL antibodies and CRP levels both in patients with ACS and stable CAD. The association between the two biomarkers was stronger in the ACS group. In conclusion, our findings support the notion that the presence of antibodies to oxLDL, a plaquespecific antigen, plays a major role as a predictor of complicated manifestations of ACS.

Keywords

Atherosclerosis - coronary artery disease - antibodies to oxidized LDL - C-reactive protein
 

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