FIGURE 5 from Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins

The prognosis effects of the KIPA-based PBP signature in METABRIC dataset. A, Forest plot shows HRs and P values for disease-specific survival associated with the PBP signature and seven signature genes. HR and 95% confidence intervals were based on categorizing TNBC samples using a median mRNA expression cutoff for each gene or the PBP signature score in the METABRIC dataset. Survival analysis was also performed for clinical factors (lymph nodes number, tumor size, and tumor grade). Blue boxes indicate univariate analysis, and red boxes indicate multivariate analysis. B, Kaplan–Meier curve shows disease-specific survival of TNBC samples from the METABRIC dataset. Samples were categorized into mRNA-based PBP signature score high and low group based on the median cutoff.