Figure S9 from Systemic Treatments and Molecular Biomarkers for Perivascular Epithelioid Cell Tumors: A Single-institution Retrospective Analysis

Testa, Stefano; Bui, Nam Q.; Ganjoo, Kristen N.

doi:10.1158/2767-9764.23664983.v1

crc-23-0139-s09.docx (185.67 kB)

Figure S9 from Systemic Treatments and Molecular Biomarkers for Perivascular Epithelioid Cell Tumors: A Single-institution Retrospective Analysis

journal contribution

posted on 2023-07-12, 02:20 authored by Stefano Testa, Nam Q. Bui, Kristen N. Ganjoo

Figure S9 shows Kaplan-Meier curves for combined clinical PFS in patients with malignant PEComas. Specifically, figure shows effects on combined clinical PFS of TFE3 positivity, treatment type, and TP53 and TSC1/TSC2 mutational status.

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History

ARTICLE ABSTRACT

This study examines systemic treatments for advanced PEComas, a rare group of sarcomas, and identifies molecular biomarkers of prognosis. Our results show that mTOR inhibitors have similar efficacy as chemotherapy, and that TFE3 overexpression, on IHC or FISH, correlates with a more aggressive disease course.