Supplementary figure 4 from Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
posted on 2023-03-31, 00:03authored byMaría E. Rodriguez-Ruiz, Inmaculada Rodriguez, Saray Garasa, Benigno Barbes, Jose Luis Solorzano, Jose Luis Perez-Gracia, Sara Labiano, Miguel F. Sanmamed, Arantza Azpilikueta, Elixabet Bolaños, Alfonso R. Sanchez-Paulete, M. Angela Aznar, Ana Rouzaut, Kurt A. Schalper, Maria Jure-Kunkel, Ignacio Melero
A course of radiotherapy plus immunostimulatory monoclonal antibodies anti-CD137 and anti-PD-1 mAb increases CD4 and CD8 T cells in the tumor infiltrate as well as the number of tumor antigen-specific CD8 T cells.
Funding
MICINN
Departamento de Salud del Gobierno deNavarra
Redes temáticas de investigación cooperativa RETICC
European Commission VII Framework and Horizon 2020 programs