Two-weight, weak type norm inequalities for fractional integral operators and commutators on weighted Morrey and amalgam spaces

Let $0<\gamma<n$ and $I_\gamma$ be the fractional integral operator of order $\gamma$, $I_{\gamma}f(x)=\int_{\mathbb R^n}|x-y|^{\gamma-n}f(y)\,dy$, and let $[b,I_\gamma]$ be the linear commutator generated by a symbol function $b$ and $I_\gamma$, $[b,I_{\gamma}]f(x)=b(x)\cdot I_{\gamma}f(x)-I_\gamma(bf)(x)$. This paper is concerned with two-weight, weak type norm estimates for such operators on the weighted Morrey and amalgam spaces. Based on weak-type norm inequalities on weighted Lebesgue spaces and certain $A_p$-type conditions on pairs of weights, we can establish the weak-type norm inequalities for fractional integral operator $I_{\gamma}$ as well as the corresponding commutator in the framework of weighted Morrey and amalgam spaces. Furthermore, some estimates for the extreme case are also obtained on these weighted spaces.


Fractional Integral Operators.
Let R n be the n-dimensional Euclidean space equipped with the Euclidean norm | · | and the Lebesgue measure dx. For given c, 0 < c < n, the fractional integral operator (or Riesz potential) I c with order c is defined by (see [1] for the basic properties of I c ) Weighted norm inequalities for fractional integral operators arise naturally in harmonic analysis and have been extensively studied by several authors. e study of twoweight problem for I c was initiated by Sawyer in his pioneer paper [2]. By a weight w, we mean that w is a nonnegative and locally integrable function. In [2], Sawyer concerned the following question. Suppose that 1 < p ≤ q < ∞. For which pairs of weights (w, ]) on R n is the fractional integral operator bounded from L p (]) into weak-L q (w)? A necessary and sufficient condition for the weak-type (p, q) inequality was given by Sawyer. More specifically, he showed the following.
Theorem 1 (see [2]). Let 0 < c < n and 1 < p ≤ q < ∞. Given a pair of weights (w, ]) on R n , the weak-type inequality holds for any σ > 0 if and only if for all cubes Q in R n . Here, χ Q denotes the characteristic function of the cube Q, p ′ � p/(p − 1) denotes the conjugate index of p, and C is a universal constant. [3,4,[5][6][7][8][9]), but it has the defect that condition (3) involves the fractional integral operator I c itself. In [3], Cruz-Uribe and Pérez considered the case when q � p and found a sufficient A p -type condition on a pair of weights (w, ]) which ensures the boundedness of the operator I c from L p (]) into weak-L p (w), where 1 < p < ∞. e condition (4) given below is simpler than (3) in the sense that it does not involve the operator I c itself, and hence it can be more easily verified.
Theorem 2 (see [3]). Let 0 < c < n and 1 < p < ∞. Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , en, the fractional integral operator I c satisfies the weak-type (p, p) inequality σ · w x ∈ R n : I c f(x) > σ where C does not depend on f nor on σ > 0. e proof of eorem 2 is quite complicated. It depends on an inequality relating the Hardy-Littlewood maximal function and the sharp maximal function which is strongly reminiscent of the good-λ inequality of Fefferman and Stein. For another, more elementary proof, see also [4]. is solves a problem posed by Sawyer and Wheeden in [8]. Moreover, in [5], Li improved this result by replacing the "power bump" in (4) by a smaller "Orlicz bump" (see also [10]). On the other hand, for given 0 < c < n, the linear commutator [b, I c ] generated by a suitable function b and I c is defined by is commutator was first introduced by Chanillo in [11]. In [6], Liu and Lu obtained a sufficient A p -type condition for the commutator [b, I c ] to satisfy a two-weight weak-type (p, p) inequality, where 1 < p < ∞.
at condition is an A p -type condition in the scale of Orlicz spaces (see (7) given below).
Theorem 3 (see [6]). Let 0 < c < n, 1 < p < ∞ and b ∈ BMO(R n ). Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , where A(t) � t p′ (1 + log + t) p′ and log + t ≔ max logt, 0 , that is, en, the linear commutator [b, I c ] satisfies the weaktype (p, p) inequality where C does not depend on f nor on σ > 0. In [7], Martell considered the case when q > p and gave a verifiable condition which is sufficient for the twoweight, weak-type (p, q) inequality for fractional integral operator I c . e condition (10) given below (in the Euclidean setting of [7]) is also simpler than the one in eorem 1.
Theorem 4 (see [7]). Let 0 < c < n and 1 < p < q < ∞. Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , en, the fractional integral operator I c satisfies the weak-type (p, q) inequality where C does not depend on f nor on σ > 0. Furthermore, in [9], Zhang sharpened Martell's result by replacing the local L r norm on the left-hand side of (10) by the smaller Orlicz space norm. On the other hand, by comparing eorem 4 with eorems 2 and 3, it is natural to conjecture that when q > p, there is a twoweight, weak-type (p, q) inequality for the commutator [b, I c ] of fractional integral operator. By using the same method as in the proof of eorem 1 in [12] and certain Orlicz norm, we are able to obtain the following sufficient condition on a pair of weights (w, ]) to ensure the L p (]) ⟶ WL q (w) boundedness of [b, I c ], whenever b belongs to BMO(R n ). More specifically, the following statement is true.

2
Abstract and Applied Analysis Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , where A(t) � t p′ (1 + log + t) p′ . en, the linear commutator where C does not depend on f nor on σ > 0. e details are omitted here. Note that condition (12) reduces to condition (7) provided that p � q.
Question. In view of eorems 2-5, it is a natural and interesting problem to find some sufficient conditions for which the two-weight, weak-type norm inequalities hold for the operators I c and [b, I c ], in the endpoint case p � 1.
In this paper, we are mainly interested in the weighted Morrey spaces and weighted amalgam spaces. Let us recall their definitions.

Weighted Morrey Spaces.
e classical Morrey space L p,λ (R n ) was introduced by Morrey [12] in connection with elliptic partial differential equations. Let 1 ≤ p < ∞ and 0 ≤ λ ≤ n. We recall that a real-valued function f is said to belong to the space L p,λ (R n ) on the n-dimensional Euclidean space R n , if the following norm is finite: where B(x, r) � y ∈ R n : |x − y| < r is the Euclidean ball with center x ∈ R n and radius r ∈ (0, ∞) as well as the Lebesgue measure |B(x, r)| � v n · r n . Here, v n is the volume of the unit ball of R n . In particular, one has In [13], Komori and Shirai considered the weighted case and introduced a version of weighted Morrey space, which is a natural generalization of weighted Lebesgue space. Definition 1. Let 1 < p < ∞ and 0 ≤ κ < 1. For two weights w and ] on R n , the weighted Morrey space L p,κ (], w) is defined by where the norm is given by (17) and the supremum is taken over all cubes Q in R n . Definition 2. Let 1 < p < ∞, 0 ≤ κ < 1, and w be a weight on R n . We define the weighted weak Morrey space WL p,κ (w) as the set of all measurable functions f satisfying By definition, it is clear that 1.3. Weighted Amalgam Spaces. Let 1 ≤ p, s ≤ ∞, a function f ∈ L p loc (R n ) is said to be in the Wiener amalgam space (L p , L s )(R n ) of L p (R n ) and L s (R n ), if the function y⟼‖f(·) · χ B(y,1) ‖ L p belongs to L s (R n ), where B(y, 1) is an open ball in R n centered at y with radius 1, χ B(y,1) is the characteristic function of the ball B(y, 1), and ‖·‖ L p is the usual Lebesgue norm in L p (R n ). In [14], Fofana introduced a new class of function spaces (L p , L s ) α (R n ) which turned out to be the subspaces of (L p , L s )(R n ). More precisely, for 1 ≤ p, s, α ≤ ∞, we define the amalgam space (L p , L s ) α (R n ) of L p (R n ) and L s (R n ) as the set of all measurable functions f with the usual modification when p � ∞ or s � ∞, and |B(y, r)| is the Lebesgue measure of the ball B(y, r). As it was shown in [14] that the space (L p , L s ) α (R n ) is nontrivial if and only if p ≤ α ≤ s, in the remaining of this paper, we will always assume that this condition p ≤ α ≤ s is satisfied. Let us consider the following two special cases: Abstract and Applied Analysis 3 (1) If we take p � s, then p � α � s. By Fubini's theorem, it is easy to check that where the last equality holds since |B(y, r)| − 1 · |B(x, r)| � 1. Hence, the amalgam space (L p , L s ) α (R n ) is equal to the Lebesgue space L p (R n ) with the same norms provided that p � α � s. (2) If s � ∞, then we can see that in such a situation, the amalgam space (L p , L s ) α (R n ) is equal to the classical Morrey space L p,λ (R n ) with equivalent norms, where λ � (pn)/α.
In this paper, we will consider the weighted version of (L p , L s ) α (R n ).
Definition 3. Let 1 ≤ p ≤ α ≤ s ≤ ∞ and let ], w, and μ be three weights on R n . We denote by (L p , L s ) α (], w; μ) the weighted amalgam space, the space of all locally integrable functions f, such that with w(Q(y, ℓ)) � Q(y,ℓ) w(x)dx and the usual modification when s � ∞.
Definition 4. Let 1 ≤ p ≤ α ≤ s ≤ ∞, and let w, μ be two weights on R n . We denote by (WL p , L s ) α (w; μ) the weighted weak amalgam space consisting of all measurable functions f such that with w(Q(y, ℓ)) � Q(y,ℓ) w(x)dx and the usual modification when s � ∞.
Note that in the particular case when μ ≡ 1, this kind of weighted (weak) amalgam space was introduced by Feuto in [15] (see also [16]). We remark that Feuto [15] considered ball B instead of cube Q in his definition, but these two definitions are evidently equivalent. Also, note that when 1 ≤ p ≤ α and s � ∞, then (L p , L s ) α (], w; μ) is just the weighted Morrey space L p,κ (], w) with κ � 1 − p/α, and (WL p , L s ) α (w; μ) is just the weighted weak Morrey space Recently, in [17][18][19], the author studied the two-weight, weak-type (p, p) inequalities for fractional integral operator, as well as its commutators on weighted Morrey and amalgam spaces, under some A p -type conditions (4) and (7) on the pair (w, ]). As a continuation of the works mentioned above, in this paper, we consider related problems about two-weight, weak-type (p, q) inequalities for I c and [b, I c ], under some other A p -type conditions (10) and (12) on (w, ]) and 1 < p < q.

Statement of Our Main Results
We are now in a position to state our main results. Let p ′ be the conjugate index of p whenever p > 1; that is, 1/p + 1/p ′ � 1. First, we give the two-weight, weak-type norm inequalities for the fractional integral operator in the setting of weighted Morrey and amalgam spaces. Theorem 6. Let 0 < c < n, 1 < p < q < ∞ and 0 < κ < p/q. Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , If w ∈ Δ 2 , then the fractional integral operator I c is bounded from L p,κ (], w) into WL q,(κq)/p (w).

Theorem 7.
Let 0 < c < n, 1 < p < q < ∞ and μ ∈ Δ 2 . Given a pair of weights (w, ]) on R n , assume that for some r > 1 and for all cubes Q in R n , Next, we introduce the definition of the space of BMO(R n ) (see [20]). Suppose that b ∈ L 1 loc (R n ) and let where b Q denotes the mean value of b on Q, namely, and the supremum is taken over all cubes Q in R n . Define If we regard two functions whose difference is a constant as one, then the space BMO(R n ) is a Banach space with respect to the norm ‖·‖ * . Concerning the two-weight weak-type estimates for the linear commutator [b, I c ] in the context of weighted Morrey and amalgam spaces, we have the following results.
. Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , where . Given a pair of weights (w, ]) on R n , assume that for some r > 1 and for all cubes Q in R n , where Moreover, for the extreme case κ � p/q of eorem 6, we will prove the following theorem, which could be viewed as a supplement of eorem 6. Theorem 10. Let 0 < c < n and 1 < p < q < ∞. Given a pair of weights (w, ]) on R n , suppose that for some r > 1 and for all cubes Q in R n , If κ � p/q and w ∈ Δ 2 , then the fractional integral operator I c is bounded from L p,κ (], w) into BMO.
In addition, we will also discuss the extreme case β � s of eorem 7. In order to do so, we need to introduce the following new BMO-type space.
e space (BMO, L s )(μ) is defined as the set of all locally integrable functions f satisfying ‖f‖ ** < ∞, where Here, the L s (μ)-norm is taken with respect to the variable y. We also use the notation f Q(y,ℓ) to denote the mean value of f on Q(y, ℓ).
Observe that if s � ∞, then (BMO, L s )(μ) is just the classical BMO space given above. Now, we can show that I c is bounded from (L p , L s ) α (], w ; μ) into our new BMO-type space defined above. is new result may be viewed as a supplement of eorem 7.

Notation and Definitions
In this section, we recall some standard definitions and notation.
3.1. Weights. For given y ∈ R n and ℓ > 0, we denote by Q(y, ℓ) the cube centered at y and has side length ℓ > 0, and all cubes are assumed to have their sides parallel to the coordinate axes. Given a cube Q(y, ℓ) and λ > 0, λQ(y, ℓ) stands for the cube concentric with Q and having side length λ � n √ times as long, i.e., λQ(y, ℓ) ≔ Q(y, λ � n √ ℓ). A nonnegative function w defined on R n will be called a weight if it is locally integrable. For any given weight w and any Lebesgue measurable set E of R n , we denote the characteristic function of E by χ E , the Lebesgue measure of E by |E|, and the weighted measure of E by Given a weight w, we say that w satisfies the doubling condition, if there exists a finite constant C > 0 such that for any cube Q in R n , we have When w satisfies this condition (34), we denote w ∈ Δ 2 for brevity. A weight w is said to belong to Muckenhoupt's class holds for every cube Q in R n . e class A ∞ is defined as the union of the A p classes for 1 < p < ∞, i.e., A ∞ � ∪ 1<p<∞ A p . If w is an A ∞ weight, then we have w ∈ Δ 2 (see [21]). Moreover, this class A ∞ is characterized as the class of all weights satisfying the following property: there exists a number δ > 0 and a finite constant C > 0 such that (see [21]) holds for every cube Q ⊂ R n and all measurable subsets E of Q. Given a weight w on R n and for 1 ≤ p < ∞, the weighted Lebesgue space L p (w) is defined to be the collection of all measurable functions f satisfying For a weight w and 1 ≤ p < ∞, define the distribution function of f with w by where λ is a positive number. We say that f is in the weighted weak Lebesgue space WL p (w), if there exists a constant C > 0 such that 3.2. Orlicz Spaces. We next recall some basic facts from the theory of Orlicz spaces needed for the proofs of the main results. For more information about these spaces the reader may consult the book [22]. Let A: [0, +∞) ⟶ [0, +∞) be a Young function. at is, a continuous, convex, and strictly increasing function satisfying A(0) � 0 and A(t) ⟶ + ∞ as t ⟶ + ∞. For a Young function A and a cube Q in R n , we will consider the A-average of a function f given by the following Luxemburg norm: In particular, when A(t) � t p with 1 < p < ∞, it is easy to see that that is, the Luxemburg norm in such a situation coincides with the normalized L p norm. e main examples that we are going to consider are A(t) � t p (1 + log + t) p with 1 < p < ∞. roughout the paper, C always denotes a positive constant independent of the main parameters involved, but it may be different from line to line. We will use A ≈ B to denote the equivalence of A and B; that is, there exist two positive constants C 1 and C 2 independent of A and B such that

Proofs of Theorems 6 and 7
Proof of eorem 6. Let f ∈ L p,κ (], w) with 1 < p < q < ∞ and 0 < κ < p/q. For an arbitrary fixed cube Q � Q(x 0 , ℓ) in R n , we decompose f as where 2Q ≔ Q(x 0 , 2 � n √ ℓ) and χ 2Q denotes the characteristic function of 2Q. For any given σ > 0, we then write Let us consider the first term I 1 . Using eorem 4 and the condition w ∈ Δ 2 , we have is is exactly what we want. We now deal with the second term I 2 . Note that |x − y| ≈ |x 0 − y|, whenever x, x 0 ∈ Q and y ∈ (2Q) c . For 0 < c < n and all x ∈ Q, using the standard technique, we can see that is pointwise estimate (45) together with Chebyshev's inequality yields By using Hölder's inequality with exponent p > 1, we can deduce that Moreover, we apply Hölder's inequality again with exponent r > 1 to get is indicates that e last inequality is obtained by the A p -type condition (10) assumed on (w, ]). Furthermore, since w ∈ Δ 2 , we can easily check that there exists a reverse doubling constant D � D(w) > 1 independent of Q such that (see ( [13], Lemma 4.1)) which implies that for any positive integer j, by induction principle. Hence, where the last series is convergent since the reverse doubling constant D > 1 and 1/q − κ/p > 0. erefore, in view of (52), we get which is our desired inequality. Combining the above estimates for I 1 and I 2 and then taking the supremum over all cubes Q ⊂ R n and all σ > 0, we complete the proof of eorem 6.

Abstract and Applied Analysis
In addition, we apply Hölder's inequality again with exponent r > 1 to get Hence, in view of (64) and (57), we have e last inequality is obtained by the A p -type condition assumed on (w, ]). Furthermore, arguing as in the proof of eorem 6, we know that for any positive integer j, there exists a reverse doubling constant D � D(w) > 1 independent of Q(y, ℓ) such that Hence, we compute ∞ j�1 w(Q(y, ℓ)) 1/β− 1/s w(Q(y, ℓ)) D j+1 · w(Q(y, ℓ)) where the last series is convergent since the reverse doubling constant D > 1 and 1/β − 1/s > 0. erefore, by taking the L s (μ)-norm of both sides of (55) (with respect to the variable y) and then using Minkowski's inequality, (60) and (65), we obtain Abstract and Applied Analysis where the last inequality follows from (67).
us, by taking the supremum over all ℓ > 0, we finish the proof of eorem 7.

Proofs of Theorems 8 and 9
For the results involving commutators, we need the following properties of BMO(R n ), which can be found in [23,24].

Lemma 1. Let b be a function in BMO(R n ).
(i) For every cube Q in R n and for any positive integer j, (ii) Let 1 < p < ∞. For every cube Q in R n and for any Before proving our main theorems, we will also need a generalization of Hölder's inequality due to O'Neil [25].

Lemma 2. Let A, B, and C be Young functions such that for all t > 0,
where A − 1 (t) is the inverse function of A(t). en, for all functions f and g and all cubes Q in R n , We are now ready to give the proofs of eorems 8 and 9.
Proof of eorem 8. Let f ∈ L p,κ (], w) with 1 < p < q < ∞ and 0 < κ < p/q. For any given cube Q � Q(x 0 , ℓ) ⊂ R n , as before, we decompose f as w); . en, for any given σ > 0, one (74) Applying eorem 5 and doubling inequality (34), we have On the other hand, for any x ∈ Q, from (6), it then follows that us, we can further split J 2 into two parts as follows: (77) Using the pointwise estimate (45) and Chebyshev's inequality, we obtain that 10 Abstract and Applied Analysis where the last inequality is due to the assumption w ∈ A ∞ and Lemma 1 (ii). By the same manner as in the proof of eorem 6, we can also show that Similar to the proof of (45), for all x ∈ Q, we can show the following pointwise inequality as well: is, together with Chebyshev's inequality, yields An application of Hölder's inequality leads to that where C(t) � t p′ is a Young function by (41). For 1 < p < ∞, it is immediate that the inverse function of C(t) is C − 1 (t) � t 1/p′ . Also, observe that the following identity is true: Moreover, it is easy to see that Let ‖h‖ expL,Q denote the mean Luxemburg norm of h on cube Q with Young function B(t) ≈ exp(t) − 1. According to Lemma 2, we have Abstract and Applied Analysis where in the last inequality, we have used the well-known fact that (see [23]) Indeed, the above inequality (86) is equivalent to the following inequality: which is an immediate consequence of the celebrated John-Nirenberg's inequality (see [20]). Consequently, in view of (86) and (48), we can deduce that Since w ∈ A ∞ , we know that w ∈ Δ 2 . Furthermore, by the A p -type condition (12) on (w, ]) and the estimate (52), we obtain It remains to estimate the last term J 6 . Making use of the first part of Lemma 1 and Hölder's inequality, we get Let C(t) and A(t) be the same as before. Clearly, C(t) ≤ A(t) for all t > 0; then, for any cube Q in R n , one has ‖f‖ C,Q ≤ ‖f‖ A,Q by definition, which implies that condition (12) is stronger than condition (10). is fact together with (48) yields Moreover, by our hypothesis on w: w ∈ A ∞ , there exists a number δ > 0 such that the inequality (36) holds, and hence we compute where the last series is convergent since the exponent δ(1/q − κ/p) is positive. is implies our desired estimate Summarizing the estimates derived above and then taking the supremum over all cubes Q ⊂ R n and all σ > 0, we conclude the proof of eorem 8.

□
Proof of eorem 9. Let 1 < p ≤ α < s ≤ ∞ and f ∈ (L p , L s ) α (], w; μ) with w ∈ A ∞ and μ ∈ Δ 2 . For any fixed cube Q � Q(y, ℓ) in R n , as usual, we decompose f as where 2Q � Q(y, 2 � n √ ℓ). en, for given y ∈ R n and ℓ > 0, we write w (Q(y, ℓ) Next, we shall calculate the two terms, respectively. According to eorem 5, we get where the last identity is due to (57). Moreover, since w ∈ A ∞ , we know that w ∈ Δ 2 , and hence by inequality (59), On the other hand, from (6), one can see that for any Consequently, we can further divide J 2 (y, ℓ) into two parts: Abstract and Applied Analysis 13 For the term J 3 (y, ℓ), it follows directly from Chebyshev's inequality and estimate (61) that where in the last inequality, we have used the fact that w ∈ A ∞ and Lemma 1 (ii). Arguing as in the proof of eorem 7, we can also obtain that Let us now estimate the other term J 4 (y, ℓ). As it was shown in eorem 8 (see (81)), the pointwise estimate holds for any x ∈ Q(y, ℓ) by a routine argument. is, together with Chebyshev's inequality, implies that An application of Hölder's inequality leads to that where C(t) � t p′ is a Young function. Recall that the inequalities hold by generalized Hölder's inequality and the estimate (87), where Moreover, in view of (64) and (106), we can deduce that e last inequality is obtained by the A p -type condition (12) assumed on (w, ]). We now turn our attention to the last term J 6 (y, ℓ). Applying Lemma 1 (i) and Hölder's inequality, we get Abstract and Applied Analysis Also, observe that condition (12) is stronger than condition (10). Using this fact along with (64), we have Summing up all the above estimates and taking into consideration (57), we conclude that commutators [b, I c ] m are bounded from (L p , L s ) α (], w; μ) into (WL q , L s ) β (w; μ) with 1/β � 1/α − (1/p − 1/q).

Proofs of Theorems 10 and 11
In the last section, we will prove the conclusions of eorems 10 and 11.
Proof of eorem 10. Let f ∈ L p,κ (], w) with 1 < p < q < ∞ and κ � p/q. For any given cube Q � Q(x 0 , ℓ) in R n , it suffices to prove that the inequality 1 holds. Decompose f as . By the linearity of the fractional integral operator I c , the left-hand side of (117) can be divided into two parts. at is, For the first term I, it follows directly from Fubini's theorem that It is clear that when x ∈ Q and y ∈ 4Q. Using the transform x − y↦z and polar coordinates, one has Here, we use w n− 1 to denote the measure of the unit sphere in R n . is indicates that For the second term II, by (1), we have that for any x ∈ Q,  Since both x and y are in Q, z ∈ (4Q) c , by a routine geometric observation, we must have |x − z| ≥ 2|x − y| and |x − z| ≈ |z − x 0 |. is fact along with the mean value theorem yields By the same reason as in the proof of eorem 10 (see (126)), we can show that for any x ∈ Q(y, ℓ), Furthermore, by using Hölder's inequality, the preceding expression in (136) can be estimated as follows: where the last equality is also due to the fact that 1/α− 1/p − 1/s � − 1/q. It then follows from (137) and (64) that Consequently, Abstract and Applied Analysis 21 ≤ ‖I(y, ℓ)‖ L s (μ) +‖II(y, ℓ)‖ L s (μ) We end the proof by taking the supremum over all ℓ > 0.

Data Availability
No data were used to support this study.

Conflicts of Interest
e author declares that there are no conflicts of interest regarding the publication of this paper.