A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem

Mangrove ecosystem has many potential species that are traditionally used by the coastal communities for their traditional cure for health ailments as evidenced by their extensive uses to treat hepatic disorders, diabetes, gastrointestinal disorders, anti-inflammation, anticancer, and skin diseases, etc. In recent times, the diabetes mellitus (DM), a serious physiological disorder all over the world, occur due to the relative or complete deficiency of insulin in the body, characterized by an abnormally high blood glucose level. India has a rich traditional knowledge on plant-based drug formulations that are protective and curative for many health ailments. In this context, we aimed to compile the works done on the antidiabetic activities of mangrove species from Indian coastal regions especially on Andaman and Nicobar Islands as well as some recent works reported from other countries. A total of 126 published articles and 31 mangrove species related pieces of information were gathered with reference to antidiabetic properties of mangroves. This review summarizes the chemical structures, molecular formula, molecular weight, and their biological activities with an aspiration that it might be helpful for the future bioprospecting industries who are interested in develop the natural drugs for DM.


Introduction
Mangrove species grow at the edge between the coastal and land area in subtropical and tropical regions of the world and are highly adapted to various temperatures, strong coastal winds, extreme tidal waves, salinity fluctuations, coastal water turbulence, river run-off, and anaerobic soil. No other wild species exhibit such physiological and morphological adaptations to the extreme conditions. e worldwide diversity of mangrove flora includes around 81 tree and shrub species of 30 genera from 17 families. Of these, Indian mangroves represent 46 true mangrove species (42 species and 4 natural hybrids) belonging to 14 families and 22 genera [1] (Figure 1). e unique ecology and ecosystem services, plant morphological characteristics, and traditional uses of mangrove plants have already drawn the attention to researchers over the years. Mangroves possess unique biochemical functions in their ecosystem and are considered as a source of novel natural/ biological products. Mangroves are rich resources of compounds like polyphenols and tannins. Further, mangrove leaves also possess phenolic compounds, alkaloids, and flavonoids which serve as novel bioactive compounds.

Drugs from Traditional
Knowledge. Traditional medicine has long been used as the primary source of therapeutic drugs. e attention on traditional medicine is escalating as there is substantial evidence that it can be a potential source for drugs to combat diseases. e scope and value of traditional medicine research assume greater importance in the realm of healthcare of humankind. In spite of the increased usage of synthetic drugs in modern medicine, half of the world's medicinal compounds are still derived from plants [2]. Some of the most important medicines which have modernized into the modern medical systems have been isolated initially from the plants that were used by ancient society. ese wonder drugs include the curare alkaloids, penicillin, and other antibiotics, cortisone [3], reserpine, veratrum alkaloids, podophyllotoxin, and other therapeutic agents [4] (Figure 2). Considering the fact that natural compounds isolated from plants are more economical and may have a holistic effect, assessing traditional knowledge for drug discovery is imperative. Morphine is a well-known product of natural plant medicine.
Drug discovery through traditional knowledge has numerous challenges due to the plethora of ancient and ethnobotanical texts describing myriads of applications of the medicinal plant [5].
us, a research program involving potential leads from traditional knowledge and screening based on computational methods like molecular docking, pharmacophore modeling, and molecular dynamics to identify the potential leads and final validation of potential leads through biological studies can be an economical and time-saving approach for drug discovery.

Traditional Knowledge Worldwide: A Brief.
Traditional knowledge (TK) based traditional medicines (TM) are generally developed and practiced by primitive communities, based on their medicine experiences, success rate, and depending on numerous trail and errors basis [6]. World Health Organization (WHO) estimates that about 80% of the world population relies on traditional systems of medicine for primary health needs [6]. Scientific literatures from last decade [7][8][9] and many official factsheets published by WHO stated that, among Asian and African regions, about 85% of the people depend on TM derived by TK practitioners using various primary health care systems    Evidence-Based Complementary and Alternative Medicine Every year, medicinal plant-based trade is growing rapidly and India's share in the global market of natural drugs is very low as it contributes only 0.5-1%, whereas demand for these products is increasing at a rapid rate [13,14]. Developing countries and their traditional people have contributed considerably to the global drugs industry [15].
In India, the epic poems such as Vedas and others illustrated our culture, food, and habitat. e extensive use of TM in the Indian coastal region, composed mainly of plants based derivatives, has been linked to communities' composition and cultural aspects. is is why the WHO and World Bank promotes integrated approaches to documents TK and TM in their healthcare system. In the rural areas of India, 70% of the population is dependent on traditional medicines. Indigenous or traditional knowledge has developed from understanding and documenting the processes in nature. Since ethnobotany is a rapidly expanding science, beginning with the study of plants used by tribals for food, medicine, and shelter, now it includes studies like conservational practices of tribals, ethnopharmacology, ethnopharmacognosy, ethnomusicology, ethnogynaecology, etc. Ethnobotanical studies in relation to traditional communities like the tribal groups have been studied by several researchers in India including the island's ecosystem.
India is rich in its diverse natural resources and one of the seventeen biggest natural biodiversity countries of the world. It has rich vegetation of more than 45,000 plant species, out of which 15,000 to 20,000 plants are estimated to have medicinal values. Out of these, only 7,000 to 7,500 plants are used for the medicinal purpose by established communities [16,17]. e marine biodiversity is an extremely rich resource for the development of a wide array of goods and services in the food web, pharmaceuticals, cosmetics, coastal protection, etc., but it has been extensively utilized for curing various ailments for many tribal and native communities inhabiting the coastal lines in different parts of the world. As a result of the close and respectful interaction with the marine ecosystem, the indigenous coastal communities possess marine life based rich traditional knowledge that also aids in the sustainable development of the community as well as the marine ecosystem. e valuable traditional knowledge (TK) has so far remained confined within their community and generally passed orally from one generation to another [18]. Various forms of TK, including TM knowledge, have been silently developing over the 19 th centuries, with the coastal tribes in nations across the world. Unfortunately, marine TK and TM have been underestimated both commercially and legally. It has still not gained its due importance at the international platform for sustainable use and development of new drugs [18,19].

Traditional Knowledge of the Andaman and Nicobar
Island. Andaman and Nicobar island (ANI), a union territory of the Republic of India, located in the Bay of Bengal, is blessed with the enchanting beauty of whitey sandy beaches, blueish coast, and unique tropical islands with biologically rich flora and fauna [20]. e Andaman and Nicobar archipelago consisting of about 525 islands and islets lies in the Bay of Bengal and forms an arched string stretching geologically from Arakan Yoma in Myanmar in the north to Sumatra in the south (6 o 4′and 13 o 41′N latitude and 92 o 11′ and 94 o 10′E longitude) with a land area of 8290 km 2 . Floristically, there are 2654 species belonging to 1083 genera and 237 families, of which 308 species are endemic. e native people of these islands belong to two races, namely, Onges, Jarawas, Sentinelese, and Great Andamanese from Andaman Islands are probably the most primitive communities in India.
e Nicobarese and the Shompen tribes are confined to Nicobar group of islands [20]. e forest resource of the islands has a rich repository of biodiversity of medicinal plants representing invaluable ethnobotanical wealth from the six indigenous tribes, namely, the Great Andamanese, Onges, Jarawas, Sentinelese, Nicobarese, and Shompens. Among them, the Great Andamanese, Onges, Jarawas, and Sentinelese originated from the Andaman Islands are probably the most primitive communities in India.
e Nicobarese and the Shompen tribes are confined only to Nicobar group of islands [21]. e island's tropical forests represent nature's major storehouse of chemicals and pharmacodynamics compounds used in the perfumery, cosmetics, and pharmaceutical industries. e folklore medicinal uses of the tribes except for the Sentinels have been documented by various researchers [16,17,[22][23][24][25][26]. Unfortunately, the traditional healing systems and knowledge of these aboriginals have largely eroded along with the natural resources, because of the lack of needed support and recognition, as well as the rapid destructions of their habitats through a series of unsustainable developmental activities such as urbanization, natural calamities, and sea level rise impact on small islands. Further, due to the exposure of these tribes with the outside people, modern lifestyle, education, and lack of time, they gradually forget their TK practices and culture and TM benefits over many decades [20]. Besides all these parameters, the aged TK practitioners who fully depend on the TM are putting their efforts in the transformation of knowledge from one generation to another, but due to the lack of interest in the younger generation, the values of TK and TM practices face the threat of getting vanished. In addition, ANI is located in the seismic hard zone of IV, which is more prone to the earthquake and tsunami waves. e 2004 Tsunami hit ANI very aggressively and 70% of coastal ecosystems were highly damaged, which led to the destruction of coastal habitats and more damages to inland areas.
In these circumstances, to preserve the genetic resources of the medicinal plants for the universal sustainable utilization, the IUCN has proposed a medicinal plant specialist group for making public awareness of ethnobotanical uses and for the conservation of these plant groups in the threating areas. e above statement clearly depicts that there is an urgent need to found out the entire uses of ethnomedicinal plants used by different tribes of the Indian 4 Evidence-Based Complementary and Alternative Medicine islands. It is also important that such bioresources are conserved and used sustainably, as the island inhabitants still source these plants from the wild for the treatment of ailments. Study of the biogeography of at least some of such medicinal plant species could be useful for further management practices. Although many research works have been carried out in the landward side for medicinal plant resources and its conservation, there is a need for the conservation and sustainable use of medicinal plants of the coastal forest areas. In this review, we attempt to cover research information of the documentation of indigenous knowledge on coastal plants and recent investigations on the biological activities of mangroves extracts especially on the antidiabetic properties, retrieved from different web sciences that focused on drug molecules identification, future perspective, research implication, and conservation of mangroves resources of ANI.

Mangrove
Plant-Based Bioactive Studies. Traditionally, mangrove plants are used in folklore medicine for the treatment of several ailments including diabetes throughout worldwide [27]. Many plants are considered to be a rich source of potent antidiabetic drugs, and these herbal preparations are considered to be devoid of any side effects. Approximately, 400 plants and their secondary metabolites, namely, alkaloids, carotenoids, flavonoids, glycosides, polyphenolic, terpenoids, and tannins molecules, were used for treating DM [28,29].
In the recent era, people from developed and developing countries are increasingly being diagnosed with diabetes. In 2016, WHO reported that approximately 400 million people globally suffer from diabetes disorder that caused about 1.6 million deaths in 2015. Further, the WHO has projected that the diabetes population will likely to be increased to 300 million in 2025 [30]. e current trends in India indicated that there is an alarming rise in the prevalence of diabetes which has gone beyond epidemic form to a pandemic one. Globally, diabetes outbreaks place an enormous amount of public health disorders. e occurrences and consequences associated with DM are found to be in high risk for countries like India (31.7%), China (20.8%), and the USA (17.7%) as reported by Balaraman et al. [6]. From this data, it is projected that by 2030, India, China, and the USA will have the largest number of people with DM [31]. Instead of being a single disorder, DM shows a series of disorders, characterized by increased fasting, postprandial glucose concentration, insulin deficiency or decreased insulin action and impaired glucose tolerance, and malfunction in lipid and protein metabolism. e long-term use of commercially available drugs for the cure of diabetes may also cause unwanted side effects. As a result, many studies are underway to find natural remedies that can effectively reduce the intensity of diabetes [32]. erefore, the management of DM in recent times possesses a big challenge throughout the world. Not only insulin but also several types of drugs that act to reduce blood glucose (insulin secretagogues, insulin sensitizers, α-glucosidase inhibitors, peptide analogues, dipeptidyl peptidase-4 inhibitors, and glucagon-like peptide-1) have been developed by current medicinal scenario. However, these synthetic oral hypoglycemic agents possess characteristic profiles of serious side effects like hypoglycemia, weight gain, gastrointestinal discomfort (disorder), nausea, diarrhea, liver function disorder, jaundice, heart failure, etc. [33]. erefore, alternative treatment way is the need of the hour.
A set of associated diseases (blood pressure etc.) in which the body cannot regulate the amount of sugar in the blood is called DM. e blood delivers glucose to provide the body with energy (sugar molecules) to perform a person's daily activities. e food a person eats is converted into glucose by the liver, thereby releasing the glucose into the bloodstream. In a healthy person, the blood glucose level is regulated by several hormones, primarily insulin secretion from pancreatic β-cell, a small organ between the stomach and liver. It also makes other important enzymes which are released directly into the gut and help digest food. Insulin allows glucose to exit from the blood into cells throughout the body, where it is used for fuel/energy. DM either does not produce enough insulin or cannot use insulin properly or both. In the disorder, blood glucose cannot move efficiently into cells, so blood glucose levels remain high. is not only starves all the cells that need glucose for fuel but also harms certain organs and tissues exposed to the high glucose levels [34]. Categorically, there are two types of DM recognized by the WHO, namely, Type 1 diabetes (insulin-dependent) and Type II diabetes (noninsulin-dependent). Treatment of diabetes is considered as the main global problem and successful treatment is yet to be discovered. Two major drugs like (i) insulin and (ii) oral hypoglycemic agents which are the first line of treatment for diabetes have some side effects and fail to significantly alter the course of diabetic complications [35]. Gurudeeban et al. showed that the crude extracts of Citrullus colocynthis, Aegle marmelos, and Ipomoea pescaprae exhibited potential α-glucosidase inhibitory activity. ese three plants can be exploited to treat diabetes [36]. Similarly, 5 different compounds (cysteine, phenylacetic acid, acrylamide, caprylone, and oleic acid) isolated from Rhizophora mucronata were evaluated for an inhibitory action on DPP IV inhibitors using in silico approach [37]. In 2014, methanolic extract of Rhizophora apiculata yielded 18 phytocompounds.
e results of GC-MS identified 18 phytocompounds, among those major peaks were 1-adamantyl-p-methylbenzalimine, clivorine, 4-butyl pyridine, 1oxide, acetamide, and p-aminodiethyl-amidine. ese major compounds were subjected to in silico analysis on human peroxisome proliferator-activated receptor gamma protein determined by Auto DOCK 4.0 and identified as thiazolidinediones [38]. Selvaraj et al. reported that α-glucosidase is the key intestinal enzyme having clinical relevance in the treatment of DM. In the study, leaf extract of R. apiculata contains a huge amount of alkaloids and exhibited significant α-glucosidase inhibitory activity (250.53 ± 0.51 mg/g) [39].
Recently, it was reported that alkaloid compound like glycosine is derived from ethanolic extract of R. apiculata. It Evidence-Based Complementary and Alternative Medicine showed antidiabetic/antihyperglycemic effect of glycosine in diabetic rats. e results showed that glycosine treatment significantly (p < 0.01) reduced the blood glucose level and increased the body weight and hemoglobin levels, highdensity lipoprotein and insulin levels, protein, and the activity of hexokinase when compared to untreated rats. Decreased activities of liver function enzymes as well as the level of urea and creatinine were observed in glycosine treated rats [40]. Selvaraj et al. exhibited dichloromethane fraction (DCM-F) of R. mucronata on noninsulin-dependent diabetes mellitus. 100 mg/kg of DCM-F treatment in diabetes rats stimulates the action of β-cells to secrete insulin and improve antihyperglycemic conditions in NIDDM. is is also clearly evident from the carbohydrates lipid profile, plasma insulin, and marker enzymes present in the serum [41]. Selvaraj et al. revealed that Aegiceras corniculatum leaf extracts showed a moderate reduction in blood glucose (382 ± 34 to 105 ± 35), glycosylated hemoglobin, a decrease in the activities of glucose-6-phosphatase and fructose-1,6-bisphosphatase, and an increase in activity of liver hexokinase active through the oral administration of extract of 100 mg/kg [42]. Satyavani et al. revealed that medicinally important mangrove species such as Acanthus ilicifolius, Excoecaria agallocha, R. apiculata, and R. mucronata were extracted for secondary metabolites with different solvents such as petroleum ether, diethyl ether and ethanol. A total of 135 chemical constituents were identified and compared with retention time in the NIST library in 2011.
Kaliamurthi et al. [44] reported on 33 medicinal plant species and documented the hypoglycemic and wound healing properties of plant species especially halophytes and its associates collected from the coastal village of Kodiyampalayam from Southeast coast of India. Kaliamurthi and Selvaraj [45] conducted several studies and elaborated the risk factors responsible for Type 2 DM including obesity, hypertension, smoking, physical inactivity, low education, dietary patterns, family history, and specific gene. Recently, researchers focused their interest on finding out the potential antidiabetic molecules from the medicinal plants to reduce the side effects caused by commercial drugs. Antinociceptive effects of E. agallocha against chemically and thermally induced nociception was studied on Albino mice which received a dosage of 10, 15, 20, or 25 mg/kg of alkaline chloroform fraction (Alk-CF). Compared with controls, Alk-CF decreased the writhing numbers (p < 0.01) in a dose-dependent manner [45]. Similarly, results showed an antinociceptive effect in mice of thillai flavonoid rutin [42].

Materials and Methods
is review was carried out by collecting information on relevant research findings with the help of Internet search engines like Google, Google Scholar, PubMed, ScienceDirect, and ResearchGate and other published articles, reports, and monographs. A total of 126 published articles have been reviewed and the related information was gathered for this current study with respect to antidiabetic research from Indian coastal region and from other countries.
is study showed that Bruguiera sp. exhibited high anticancer activity and antidiabetic activities [48,50].
Sun and Guo [69] first documented the presence of bartogenic acid 21 from the extract of stem, bark, and fruits of Barringtonia racemosa ethanolic extract. Further studies have verified the presence of bartogenic acid by K. R. Patil and C. R. Patil [70]. Bartogenic acid shows anti-DM, Gronkiewicz and Gadzikowska [52] Evidence-Based Complementary and Alternative Medicine 7 Nebula et al. [48] 8 Evidence-Based Complementary and Alternative Medicine Soodabeh et al. [64] Evidence-Based Complementary and Alternative Medicine 9 Li et al. [68] 10 Evidence-Based Complementary and Alternative Medicine Kurek et al. [74] Evidence-Based Complementary and Alternative Medicine antiarthritic activity, antitumor, antinociceptive, antibacterial, and antifungal activities and anti-inflammatory drugs [69,71]. Hexane and chloroform extracts of the leaves of Scyphiphora hydrophylacea yielded compound, namely, oleanolic acid 22. Oleanolic acid has been isolated for the first time in Sri Lanka and demonstrated in vitro cytotoxic effects in estrogen receptor-positive (MCF-7) and nonsmall lung cancer (NCI-H-292) cells [72]. Triterpenoid has been reported to show anti-inflammatory, antitumor, hepatoprotective, antidiabetic, and antibacterial properties [72][73][74].

Antidiabetic Activity of Mangrove Extracts and eir
Phytochemicals. Mangrove plants are considered to be a rich source of potent antidiabetic agents and are considered to be devoid of side effects. It is estimated that more than 400 plants and their secondary metabolites such as glycosides, alkaloids, terpenoids, flavonoids, carotenoids, tannins, polyphenolic, aliphatic alcohols, acids, amino acids, carbohydrates, hydrocarbons (including polyunsaturated fatty acids), lipids, pheromones, phorbol esters, and steroid derivatives are being used for the management of diabetes mellitus across the globe [27,28]. Mangroves are woody plants growing at the interface between the land and sea in tropical and subtropical latitudes, where they exist under conditions of high salinity, extreme tides, strong winds, high temperatures, and muddy, anaerobic soils. Asia is the richest region of mangrove species diversity with 44 species reported [49]. Some of the important mangrove plants along with their phytochemical constituents and their mechanism of antidiabetic achievement are shown in Table 2.

Acanthaceae. Acanthaceae is represented by two genera, namely, Acanthus and Avicennia.
e genus Acanthus is represented by three species in India, namely, A. ilicifolius, A. ebracteatus, and A. volubilis. Of these, A. ilicifolius is commonly distributed, while A. ebracteatus is found only in Kerala, Puducherry, and ANI at confined locations [1]. Venkataiah et al. reported that ethanolic root extract of A. ilicifolius at a dose of 200 and 400 mg/kg body weight significantly reduced the blood sugar level in normal glucose-fed hyperglycemic and alloxan-induced diabetic rats. Regeneration of β-cells has also been reported in diabetic rats [78]. Flavonoids, alkaloids, terpenoids, tannins, and steroids are present in the root extracts of this plant and this may play an important role in their hypoglycemic activities [56].

Arecaceae.
Arecaceae family is represented by two species, namely, Nypa fruticans and Phoenix paludosa. In India, both are distributed in Sundarbans and ANI. TK of N. fruticans and its uses for different ailments by the local practitioners/coastal communities of southern regions of Bangladesh and ANI has been well documented [16]. is species has very limited distribution in the Indian coast. However, the methanolic leaf and stem extracts of N. fruticans (500 mg/kg) have been reported to show their significant antihyperglycemic effect in diabetic mice [114].

Avicenniaceae.
e family Avicenniaceae is represented with genus Avicennia by three species, namely, A. alba, A. marina, and A. officinalis, and all are commonly populated in the mangrove habitats of India. Recent studies reveal that the ethanolic extract of A. marina leaf has antihyperglycemic activity in alloxan-induced diabetic rats. In addition, when the ethanolic leaf extract (250 and 500 mg/ kg) was used for the treatment of the diabetic rats for 15 days, it resulted in a significant reduction in the blood glucose levels along with an increase in total hemoglobin (Hb), total protein, and serum insulin. e leaf extract can reduce the level of serum urea that confirms the capacity to protect vital tissues, kidney, liver, and pancreas. In addition, it also improved the biochemical parameters such as serum phosphorus, albumin, and globulin. e possible mechanism underlying the antihyperglycemic action of A. marina is attributed to the stimulation of surviving β-cells that is releasing more insulin [118]. Mahera et al. [119] reported that methanolic extract of pneumatophores (aerial roots) of A. marina exhibits antihyperglycemic effect, which might be due to the inhibition of AGEs. Aljaghthmi et al. [79] [1]. e methanolic stem extract of this plant has shown to reduce serum glucose levels in doses of 200 to 400 mg/kg [88].
is activity was significantly lower compared with glibenclamide (10 mg/kg·bw), an antidiabetic drug closely related to sulfonamide antibiotics. E. agallocha has also been found to contain b-amyrin acetate which is thought to be responsible for its antidiabetic activity [120]. irumurugan et al. [89] revealed that ethanolic leaf extracts of E. agallocha species possessed significant hypoglycemic activity. Flavonoids, triterpenoids, and phenolic compounds are the bioactive principles responsible for antibiotic and antidiabetic potential compounds which are present in E. agallocha species.

Malvaceae.
Malvaceae is represented by two genera, namely, Brownlowia and Heritiera in Indian mangroves.  [112] Evidence-Based Complementary and Alternative Medicine Two species of genus Heritiera, namely, H. fomes and H. littoralis, are known from Indian mangroves, of which the former is reported only from Sundarbans and Odisha, but due to the reduction in freshwater input in both places, it has become rare. H. littoralis is known from Odisha, Maharashtra, and ANI. Dose-dependent reductions in the concentration of serum glucose in mice upon treatment with crude methanol extract of H. fomes bark are utilized for antidiabetics. At 60 minutes following glucose administration, H. fomes bark extract (250 mg/kg) significantly lowered blood glucose levels by 49.2% compared to 43.5% by glibenclamide (antidiabetic drug). It was further reported that the crude methanolic extract possesses long-term action in its glucose-lowering effect and is also better than glibenclamide drug [91]. In the future, there is an in-depth study to be needed on phytochemicals speciation of H. littoralis from Indian mangroves. In ANI, H. fomes and H. littoralis are common in both groups of islands [1]. ere is a need for more in-depth study on the bioactive compounds from the two species of genus Heritiera from ANI as well as Indian mangrove.

Bruguiera.
ere are six species present in this genus as reported throughout the world. Four species of genus Bruguiera, namely, B. gymnorrhiza, B. cylindrica, B. parviflora, and B. sexangula, are reported from India. Of these, the first two species are commonly distributed in Indian mangroves, while B. parviflora is restricted to Sundarbans, Odisha, ANI, and Maharashtra. Bark part of B. gymnorrhiza was extracted with ethanol solvent which displayed antihyperglycemic effect in streptozotocin-(STZ-) induced diabetic rats. Treatment with ethanolic bark extracts (400 mg/ kg) for 21 days reported significant reduction in blood glucose level in the STZ-induced diabetic rats, which was comparable to that of standard drug glibenclamide (0.5 mg/ kg). Further, a decreased level of total cholesterol, triglycerides, very-low-density lipoprotein, and low-density lipoprotein along with increased high-density lipoprotein level in the diabetic rats was observed [121]. Oral administration of ethanolic extract of B. gymnorrhiza normalized the levels of blood glucose in rats. e potent antidiabetic effect of the plant extract suggests the presence of various potent antidiabetic active compounds, which produced an antihyperglycemic effect in diabetic rats. e present literature survey observed that different compounds such as bruguierol, β-sitosterol, α-amyrin, β-amyrin, lupeol, oleanolic acid, ursolic acid, taraxerol, gymnorhizol, and ellagic acid were isolated from B. gymnorrhiza plant and its potent antidiabetic activity. V. adenantha Yet to be analysed Habeebulla and Velraj [90] 30.

X. moluccensis Alkaloids steroids tannins triterpenes Proanthocyanidins
Insulin mimetic or insulin secretagogue activity insulin resistance reversal activity α-glucosidase inhibitory activity Srivastava et al. [104] 14 Evidence-Based Complementary and Alternative Medicine 2.2.9. Ceriops sp. Rhizophoraceae includes the genus Ceriops that constitutes two species; C. decandra and C. tagal are common in Indian mangroves. Both species have been reported from ANI. A significant serum glucose level lowering capacity was marked in alloxan-induced diabetic mice (animal experiment model) upon oral administration of ethanolic leaf extract taken from C. decandra (120 mg/kg) developed by Nabeel et al. [32]. is capacity was comparable to that of glibenclamide (0.1 mg/kg bw). e increase in insulin secretion, body weight, and hemoglobin (Hb A1c) levels and decrease in HbA1c levels in diabetes-induced rats were due to ethanolic leaf extract of C. decandra treatments. e ethanolic C. decandra leaf extracts were found to be involved in the regulation of hexokinase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase which play a key role in glucose metabolism in mitochondria organelles. Normal levels of glucose-6-phosphatase and fructose-1,6bisphosphatase activities were observed in diabetic rats upon the administration of ethanolic C. decandra leaf extracts. Further, diabetic rats also showed increased hexokinase activity. Antihyperglycemic action of C. decandra can be attributed to its ability in stimulating surviving β-cells in pancreases to produce more insulin [32]. A study by Tiwari et al. concluded that treatment with ethanolic leaf extracts of C. tagal improved glucose tolerance of normoglycemic rats after sucrose load. e treatment also lowered blood glucose levels upon a 250 mg/kg oral dose in STZ-induced diabetic rats.
e application of hexane subfraction of ethanolic extract of C. tagal (100 mg/kg) in normal healthy rats after sucrose load proved to be most effective for antiglycemic activity. is can be compared to the effect of metformin. Unique compounds isolated from C. tagal hexane fraction showed significant inhibition against protein tyrosine phosphatases (PTPase) enzyme activity which is involved in insulin action in Type 2 diabetes [85]. Tamrakar et al. [86] reported that n-hexane soluble fraction of ethanolic leaf extracts of C. tagal stimulates glucose uptake in L6 muscle cells in a dose-dependent manner, which is comparable to metformin standard. Similarly, Lawag et al. revealed that antihyperglycemic activity of hydroalcoholic bark of C. tagal is due to its α-glucosidase inhibition potential [87].

Rhizophora sp.
ree out of the ten species of Rhizophora genus (R. apiculata, R. annamalayana, and R. mucronata) possess antidiabetic activity [56]. At 250 mg/kg doses, the ethanolic root extracts of R. apiculata showed promising antihyperglycemic activity in experimental rats. A large number of phytochemicals are found in the chloroform and aqueous subfractions of ethanolic root extract accounting for its antihyperglycemic activity. After purification, seven compounds were isolated: lupeol, oleanolic acid, β-sitosterol, palmitic acid, β-sitosterol-β-D-glucoside, inositol, and pinitol. Among these, inositol and pinitol showed promising activity in the STZ model with 100 mg/kg dose level [93]. e ethanolic leaf extracts of R. apiculata showed hypoglycemic and antihyperglycemic activities in normal, glucose-fed, and STZ diabetic rats [94]. e hypoglycemic action of R. apiculata is due to the presence of flavonoids along with other bioactive compounds. e antidiabetic properties of the hydromethanolic leaf extracts of R. apiculate are due to its radical scavenging and β-cell protection properties. Nabeel et al. have reported the antidiabetic potential of R. mucronata, R. apiculata, and R. annamalayana [56,92]. 60 mg/kg Rhizophora aqueous extract was orally administered in alloxan-induced diabetic rats. e results revealed that it aided in modulation/acceptable normal levels of blood glucose level. e noticeable antidiabetic activity was observed from the extract of R. apiculata in comparison to other mangrove extracts [92]. SDS-PAGE analysis elucidated the presence of insulin-like protein in the mangrove extracts and confirmed that assertion was done by an enzyme-linked immunosorbent assay (ELISA) [56]. erefore, the antidiabetic property in R. apiculate is clearly noted due to the secretion of insulin-like protein biomolecules and its action against reducing the blood glucose level [92].
Gaffar et al. reported the antidiabetic activity of R. mucronata and revealed that it is a plant's sole capacity to inhibit carbohydrate digestion and absorption of glucose biomolecules [95]. Haque et al. [96] reported that the bark extracts of R. mucronata aqueous layer have hypoglycemic and antihyperglycemic activities. e bark extracts showed dose-dependent antidiabetic effects which helped suppress postprandial hyperglycemia. e most probable mechanism behind the hyperglycemic effect is glucose absorption inhibition. A similar study by Lawag et al. revealed that antihyperglycemic activity of hydroalcoholic bark of R. mucronata is due to its α-glucosidase inhibition potential observed. Traditionally, R. mucronata was utilized to cure diabetes [87].

Kandelia candel.
e genus Kandelia is represented by two species, namely, K. candel and K. obovata of the family Rhizophoraceae in mangrove communities, of which the former is known from both east and west coasts of India and ANI. Mangrove species Kandelia mostly occurs in a middle zone of the mangrove ecosystem. Bark and leaves are used in the treatment of DM in different coastal regions of India.
e bark of K. candel is suitable for an industrial application like tanning heavy leather and for dyeing in red and brown colours production. Further, phytochemical analysis of the K. candel species shows flavonoid, glycosides, triterpenoids, tannins, saponins, and polyphenols compounds. However, there is no availability of comprehensive study on purified compounds of K. candel from Indian coast [

Evidence-Based Complementary and Alternative Medicine
Morada et al. reported the antidiabetic potential of methanolic leaf extracts of S. alba using in vivo mice model. e extreme blood-glucose-attenuating activity of the extract was related to complex polysaccharide molecule obtained from S. alba leaf extracts. Significant reduction in sugar level was observed during the first 6 (19.2%) and 12 h (66.9%) after the administration of the extracts to the diabetic mice [55]. Fruits of S. caseolaris have many therapeutic applications in folklore medicine [61]. Compounds such as oleanolic acid, β-sitosterol-β-D-glucopyranoside, and luteolin, which are isolated from the methanolic extract of its fruits, have shown inhibition of the α-glucosidase enzyme in a dose-dependent manner [98]. Further, the methanolic fruit extracts of this plant significantly reduced the serum glucose concentrations in mice loaded with glucose, in a dose-dependent manner [99,100]. e antihyperglycemic activities of this plant can be due to a number of factors such as decreased intestinal glucose absorption, increase in pancreatic secretions, glucose uptake, insulin secretion, and better glycemic control. Similarly, the antihyperglycemic activity of seeds and pericarps of S. apetala fruits were reported in STZ-induced diabetic mice [101]. e antihyperglycemic activity of this plant may be due to insulin mimetic activity, better glucose utilization, regeneration of islets of Langerhans in the pancreas, and enhanced transport of blood glucose to the peripheral tissue.

Myrsinaceae. A. corniculatum belongs to the family
Myrsinaceae in the mangrove communities and is commonly known from Indian mangroves. Several parts of the plant have been traditionally used for the treatment of inflammation, antioxidant, rheumatism, arthritis, free radical scavenging, and hepatoprotective activities [102]. e previous report revealed that ethanolic extract of A. corniculatum leaves regulates blood glucose level in alloxan-induced diabetic rats at a total of 100 mg/kg. Development in body weight in the diabetic-induced rat was observed along with a decrease in the activities of glucose-6-phosphatase, fructose-1,6-bisphosphatase and glycosylated hemoglobin along with the increased activity of liver hexokinase [37,56].

2.2.14.
Meliaceae. Meliaceae is represented by two genera, namely, Xylocarpus and Aglaia in mangroves. e genus Xylocarpus is represented by three species, namely, X. granatum, X. moluccensis, and X. rumphii in India. Of these X. granatum and X. moluccensis are true mangrove species, whereas X. rumphii is a nonmangrove species [1]. In India, all three species are known to occur on the coast of ANI. Srivastava et al. reported that antidiabetic activities are exhibited by X. granatum and X. moluccensis [75]. Recently, Akter et al. revealed that methanolic extract showed antibacterial, antioxidant, and cytotoxicity potential with low concentration [103]. e ethyl acetate fraction of epicarp showed antidyslipidemic effects in diabetic-induced rats [104].

Diabetes Remedies from Traditional Knowledge on
Mangrove Plants. Diabetes is one of the major public health concerns all over the world. Diabetes or hyperglycemia is considered to be one of the common public health hazards; optimal control of which is still not possible. Persistent hyperglycemia or uncontrolled diabetes has the potential to cause serious complications such as kidney disease, vision loss, cardiovascular disease, and lower-limb amputations which contributed towards morbidity and mortality in diabetes [105]. In India, traditional remedies have been used in the treatment of diabetes since the time of physicians Charaka and Sushruta. From the ethnobotanical recording, it is estimated that about 800 plants may possess antidiabetic potential [35]. Several plants have been used as a dietary adjuvant and in treating diseases even without any knowledge on their proper functions and constituents ref.
is practice may be due to its fewer side effects compared to the synthetic hypoglycemic agents and because of their safety, effectiveness, and availability [6]. Ethnobotanical information reports a huge number of plants that may possess antidiabetic potential, of which Momordica charantia, Pterocarpus marsupium, and Trigonella foenumgraecum have been reported to be beneficial for the treatment of Type 2 diabetes. roughout the world, terrestrial plants have been used in the treatments of diabetes. In contrast, very limited works have been carried out on the antidiabetic property of mangroves plants from India as well as globally.
Recently, ethnopharmacological records divulged the traditional usages of mangrove A. corniculatum (Linn.) Blanco distributed in coastal and estuarine areas of Southeast India [102]. Traditionally, more than 100 numbers of mangroves and mangrove-associated plant used for the treatment of diabetes have been reported, but only a very few numbers of plants are evaluated and reported scientifically [61]. e antidiabetic effect of leaves of mangrove plants R. mucronata and C. decandra had been documented and the gut perfusion studies on Long-Evans rats reported the mode of action of R. mucronata leaves' hypoglycemic conditions [32,95]. Recently, the medicinal values of mangroves and associated plants persist to provide priceless therapeutic agents, both in modern medicines and in traditional systems [26].

Research Gaps in Indian Mangroves
In the past few decades, there is an increase in research works on mangrove plants in terms of conservation aspects especially from India. Mangrove species from several coasts all over the world have been studied for their medicinal values and for their bioactive potential to treat diseases like cancer, rheumatism, free radical scavenging, anti-inflammatory, antinociceptive, painful arthritis, inflammation, asthma, antioxidant, DM, and as hepatoprotective agents [102,107].
However, research on developing drug derivatives from mangroves by Indian scientific communities is very limited. Based on our data compilation on antidiabetic research, we suggest that research on mangroves is very much important as there are many potential medically significant compounds that have been reported from different regions, but very limited work has been carried out from the Indian coast, specifically on the phytochemical speciation. Further, there is a large gap in antidiabetic studies on ANI mangrove resources ( Figure 3). Hence, antidiabetic studies in partnership with the indigenous communities of ANI based on their traditional knowledge are imperative.

Conclusions
In a nutshell, mangrove plants show high potential to address DM through their unique chemical structures. In recent years, most of the pharmaceutical industries are focusing mainly on the development of new drugs for DM on large-scale productions. But, there are promising potential from alternate sources like herbal medicines/traditional knowledge-based drugs which have multiple targets and potentially can be evolved as new drugs/complementary which needs serious attention. ere is an important need to renew scientific research based on traditional knowledge of indigenous communities to be included in drug discovery programs. Medicinal valued plants are one of the chief components of our natural resource which was comprised of nearly 34 true mangrove species and 12 associated mangroves species from Indian coastal region. In order to enhance the anticipation, strategic selection of particular species and shortlisting of mangroves species is a necessary task for India. New research avenues on the traditional knowledge of medicinal plants may help to conserve time, money, and side effects (toxicity), which are three key major parameters that hurdle in any drug developmental program. Since TK is a community based knowledge, the historical laws of the indigenous community should be considered. Documented traditional knowledge on medicinal values of mangroves species might simplify issues associated with poor predictability and scientific research on such knowledge will create a new pathway for developing potential drugs against diabetes. Indian coastal communities have rich traditional knowledge on plant-based drug formulations that are protective and curative for many health ailments. However, there is a large research gap in antidiabetic studies on ANI mangrove resources with coastal communities based TK. In future, Indian tropical islands mangroves resources need to be studied in detail on antidiabetic compounds extraction for new drugs mining from unexplored pristine islands ecosystem. for this study.
is study was financially and technically supported by the Ministry of Environment, Forest and