Sinusitis was produced experimentally in rabbits by the injection of the endotoxin of Hemofilus influenzae, (H. influenzae) was introduced into the maxillary sinus following sensitzing with the intra-maxillary administration of egg-white albumin. The rabbits were later sacrificed after anesthetizing with Nembutal Sodium solution.
A comparison of mucosal pathology of the sinus natural ostiums, between the normal subject and the cases with experimentally induced sinusitis, was performed by either Light Microscope (L. M.) or Scanning Electron Microscope (S. E. M.).
Every specimen was stained with Hematoxylin-Eosin (H. E.), Periodic asid Siff (P. A. S.), and High iron diamin-Alcian blue (H. I. D.-A. B.) staining methods. We found histopathological differences between the cases sensitized with eggwhite and the cases received endotoxin following sensitizing by albumin.
Also, we applied the injection replica method for observation of the blood vessel around the ostium portion. We recognized the dense plexus of blood vessels including the venous plexus and the capillary. On the basis of the results thus obtained, a relation of the mucosal pathology between the natural ostium and maxillary sinus is discussed.