Long Liu
ABSTRACT
Electrical stimulation has been widely used for neural modulation. By adjusting proper parameters, electrical stimulation could induce stable inhibition effects on targeted neurons, suggesting a potential cure for interrupting epileptic seizures. It is widely studied that the inhibition effect of electrical stimulation depends on stimulation parameters. Thus, it is important to figure out spatiotemporal inhibition effects induced by parametric changes. In this paper, multi-channel recording electrode array was applied to monitor electrophysiological changes induced by electrical stimulation simultaneously. The stimulation was delivered into rodent somatosensory cortex and neural activities were recorded around the stimulation site. Multi-channel spike firing changes were acquired with different stimulation parameters and inhibition durations were calculated accordingly. Our results showed long-term depression of neural activity lasted about 1 to 3.5 seconds which, in accordance with other studies, highly depended on parameter changes of current amplitude. The spatial responses comparison showed that within a certain range of amplitude (below 200 μA), the inhibition impact induced by electrical stimulation was focal. On the other hand, frequency modulation showed a clear frequency selectivity at about 100 Hz. These results provide some evidences on parameter selection for application of seizure treatment with electrical stimulation.
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Index Terms
- The Long-term Depression of Brain Activity Induced by Electrical Stimulation of Cerebral Cortex
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