Healthcare Chip Based on Integrated Electrochemical Sensors Used for Clinical Diagnostics of Bun

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Published 9 May 2006 • Copyright (c) 2006 The Japan Society of Applied Physics
, , Citation Chia-Hsien Chang et al 2006 Jpn. J. Appl. Phys. 45 4241 DOI 10.1143/JJAP.45.4241

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Author affiliations

1 National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan

2 Adbic In. Corp., 2-1-6 Sengen, Tsukuba, Ibaraki 305-0047, Japan

3 Department of Materials Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan

4 Graduate School of Material Science, University of Hyogo, 3-2-1 Kouto, Kamigouri, Akou-gun, Hyogo 678-1297, Japan

Dates

  1. Received 28 December 2005
  2. Accepted 11 February 2006
  3. Published

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1347-4065/45/5R/4241

Abstract

Research based on health marker sensors, such as Na+, glucose, K+ have been carried out using integrated ISE (ion selectivity electrode). In this study, focus has been placed on potentiometric measurement of ammonia and blood urea nitrogen (BUN) sensors using new 19-membered crown ionophore, TD19C6 (2,6,13,16,23,26-hexaoxaheptacyclo-[25.4.4.4 7,12.4 17,22.O 1,17.O 7,12.O 17.22]), poly(vinyl chloride) (PVC) membranes along with anionic additives, potassium tetrakis(4-chlorophenyl)borate (k-TCPB), sodium tetrakis(4-fluorophenyl)borate dehydrate (TFPB), and plasticizers, bis(1-butylphenyl)adipate (BBPA) and tris(2-ethylhexyl)trimellitate (TOTM). Screen-printed electrodes Ag/AgCl (250 mm in diameter) and a disposable polycarbonate chip (PC) designed using a trace amount of whole blood are also used.

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10.1143/JJAP.45.4241