1981 Volume 78 Issue 8 Pages 1613-1617
Using the TBA (thiobarbituric acid) test, the lipoperoxide levels were measured in needle biopsy specimens of human liver of patients with chronic liver diseases, and compared with the lipoperoxide levels in serum obtained on the day of biopsy.
The levels of serum lipoperoxide were correlated with the levels of liver lipoperoxide in patients with normal liver, alcoholic fatty liver, chronic inactive hepatitis and liver cirrhosis with normoalbuminemia. This finding suggests that hepatic lipoperoxide is secreted into blood. However, in patients with chronic active hepatitis, and liver cirrhosis with hypoalbuminemia the values of serum lipoperoxide were not related to the values of liver lipoperoxide. The patients with alcoholic fatty liver showed remarkably high levels of liver lipoperoxide, which indicates the involvement of lipid peroxidation in the pathogenesis of alcoholic liver damage in men.
Nippon Shokakibyo Gakkai Zasshi
Nippon Shokakibyo Gakkai Zasshi Kou
