Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
STUDIES ON POSTOPERATIVE HYPERAMYLASEMIA
Mitsuo MAEDA
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JOURNAL FREE ACCESS

1978 Volume 75 Issue 11 Pages 1802-1812

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Abstract

292 cases undergoing various operations (thoracic surgery: 74 cases, abdominal surgery: 56 cases and others: 162 cases) were investigated in order to clarify the nature and the mechanism of postoperative hyperamylasemia by analyzing serum amylase isoenzyme and determining amylasecreatinine clearance ratio (Cam/Ccr).
56 out of 292 cases (19.2%) showed postoperative hyperamylasemia: 10.7% were the pancreatic-type hyperamylasemia and 89.3% the salivary-type. Although the salivary-typehyperamylasemia occured following any type of operation, the pancreatic-type hyperamylasemia was found only following the surgery of pancreas itself or its adjacent organs.
Incidence of postoperative hyperamylasemia and the degree of the elevation of serum amylase activity were remarkably higher in patients undergoing thoracic surgery than in those undergoing other types of operation. However, no correlationship was found between the serum amylase activity and the doses of isoproterenol given or extracorporeal circulation time.
The normal lung tissues were revealed to have some amounts of salivary-type amylase activity and the transient salivary-type hyperamylasemia was accompanied with acute respiratory distress. These facts strongly suggest the close relationship between amylase contained in the lung tissues and the salivary-type hyperamylasemia following thoracic surgery.
Significant elevation of Cam/Ccr was observed in all cases with the pancreatic-type hyperamylasemia, while no significant change was found in the salivary-type hyperamylasemia following operation.

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© The Japanese Society of Gastroenterology
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