人工臓器
Online ISSN : 1883-6097
Print ISSN : 0300-0818
ISSN-L : 0300-0818
単離ウサギ肝細胞による肝補助装置
高橋 郁夫土肥 健純武藤 眞堀内 孝山田 豊大坪 修稲生 綱政
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ジャーナル フリー

1978 年 7 巻 6 号 p. 1074-1077

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This report describs our current attempts to design and test liver cell perfusion. Seven adult dogs were used in our experiment, they were divided in two groups at two and five respectively. One was control group, another was supported with hepatocyte group. Hepatic support system chamber was made of acryl board (10×10×1cm), and it was separated in three spaces with Neucljeopore Membrane Filter (NMF). Middle space was filled with hepatocyte (50-70g) of rabbit. This hepatocyte was isolated with #24 metal mesh from the liver which was wash out Lactete-Ringer's solution.
The chamber was connected with hepatic failure canine external shunt. The longest survival of the dog was 18 hours. This results were suggested that chamber was effective to the theraphy of hepatic failure. But the chamber membrane area was not enough to big dogs.

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© 一般社団法人 日本人工臓器学会
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