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- Small bowel
- nutritional support
- intestinal failure
- IBD clinical
- Helicobacter pylori
- acid-related diseases
- non-ulcer dyspepsia
- genetic polymorphisms
- gastric neoplasia
- ulcerative colitis
- Crohn's disease
- dietary factors
- iron nutrition
Werner et al showed that oral iron sulphate supplementation resulted in the development of ileitis in a rodent model, while parenteral administration of the same compound did not.1 I submit that these observations, although valid, may be true and unrelated. The colono-toxic effects of the sulphur component of iron sulphate were first observed following the development of acute colitis in rodents treated with dextran sodium sulphate.2 3 Sulphide compounds appear to be the most toxic to isolated colonocytes.4 Sulphate-reducing bacteria found in the colon and terminal ileum produce hydrogen sulphide,5 which in turn is converted to anionic sulphide by colonic bicarbonate.6 Hydrogen sulphide …
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Provenance and peer review Not commissioned; internally peer reviewed.
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