Background

Shigellosis is a common disease worldwide. It causes bloody stool with mucus, together with fever and abdominal cramps. The Shigella bacillus was discovered by the Japanese doctor Kiyoshi Shiga in the early 20th century (figure 1).1Shigella spp cause almost 200 million infections per year in children under the age of 5 years.2 In the Netherlands, with a population of almost 17 million, there are between 300 and 500 infections with Shigella spp annually, of which 60% after recent travel.3

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Figure 1

Dr Kiyoshi Shiga. Source: https://en.wikipedia.org/wiki/Kiyoshi_Shiga#/media/File:Kiyoshi_Shiga.jpg.28

A known complication among children is Shigella encephalopathy. It can present with altered consciousness, seizures and coma.4 5 All the known Shigella spp (Shigella sonnei, Shigella flexneri, Shigella dysenteriae and Shigella boydii) can cause this complication, with a prevalence of 12%–45% in children.6 A lethal toxic encephalopathy with rapid onset of neurological abnormalities and only a mild colitis is known as the Ekiri syndrome.7

Humans are the only host for Shigella spp. It is mostly contracted via the faecal–oral route with a low infectious dose. Shigella infections in the Western world are usually associated with travel to endemic countries. Recently, there are increasing reports of cases in men who have sex with men (MSM) without reported history of travel.8 9 The rising incidence in this population has the potential to cause outbreaks of Shigella infections in low-risk regions.10 11

Here, we present a case of an adult with Shigella-associated encephalopathy in an MSM.

Case presentation

A 45-year-old man was presented at the emergency department of our hospital with altered neurological status and a 1-day history of diarrhoea and fever. He had no relevant medical history. His male partner had found him earlier that day with fever, diarrhoea and diminished ability to speak. Heteroanamnesis revealed recent unprotected sexual contact with multiple men and no history of travel. Physical examination showed a lethargic patient with a temperature of 39.5°C, blood pressure of 100/50 mm Hg and a pulse of 104/min. He was confused and disorientated, unable to speak nor to perform any assignments. His abdomen was soft and non-tender with normal bowel sounds. Other physical examination revealed no abnormalities. Bacterial meningitis or viral encephalitis were suspected and antibiotic and antiviral therapy was started according to our local protocol;ceftriaxone, amoxicillin and acyclovir intravenously.

Investigations

A CT brain scan and lumbar puncture were performed. The CT scan showed no sign of cerebral bleeding or hydrocephalus. The cerebrospinal fluid (CSF) revealed mild pleiocytosis of 8×10⁶ cells/L with normal glucose and protein levels. Bacterial culture and PCR for enterovirus, herpes simplex virus type 1 and 2 and varicella zoster virus were negative. C reactive protein in serum was 210 mg/L with decreased leucocyte count of 2.4×10⁹ cells/L. Serum creatinine levels were elevated with 136 µmol/L. Stool culture showed S. flexneri, sensitive to ceftriaxone, though resistant to ciprofloxacin and trimethoprim/sulfamethoxazole. The patient tested negative for HIV.

Differential diagnosis

The differential diagnosis of adult with altered mental status and fever is extensive. Shigella encephalopathy was considered based on the absence of other causes and presence of S. flexneri in a stool sample.

Although the patient was hypovolaemic, this was considered unlikely as a cause for his confusion. Also, his confusion remained after volume resuscitation. Further blood investigation revealed a normal calcium, thyroid-stimulating hormone and only a slight hyponatraemia and hypokalaemia of respectively 130 mmol/L and 3.4 mmol/L, all of which could not explain his neurological status. Sepsis was considered unlikely, since blood cultures remained negative, blood pressure was within normal limits and serum lactate levels were normal. The patient had no history of substance abuse or intoxications. A delirium at time of an infection is usually seen in the elderly but can occasionally occur in younger patients with risk factors, like underlying neurological disease or the use of multiple medications. However, this was not the case in our patient.

Treatment

After the negative PCR results of the CSF acyclovir was stopped. The disturbances in fluid and electrolyte balance were treated with fluid resuscitation and potassium supplementation. Volume repletion was achieved quickly. The patient’s neurological status recovered within 36 hours after the start of ceftriaxone intravenously. Normalisation of sodium levels occurred within 24 hours and potassium levels normalised within 48 hours, after which fluid resuscitation was stopped.

Outcome and follow-up

Three days after admittance to the hospital and the start of intravenous antibiotic treatment, the patient had recovered so far that he could be discharged. The stool consistency returned to normal over time. Because of subsiding symptoms in a non-immunocompromised patient, no further antibiotic treatment was found necessary. At a follow-up visit several weeks later, he had recovered fully, except for some memory problems.