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Neuroprotective Effects of Astrocyte Extracellular Vesicles in Stroke

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Abstract—Recently, there have been a growing number of studies on the role of extracellular vesicles (EV) in brain functioning in health and disease. Signaling with the participation of astrocytic EVs under normal conditions and after ischemia is now mainly elucidated. In general, the stimuli that induce secretion of EVs from astrocytes, EV composition and the mechanism of EV binding to neurons are already known. It was shown that normal, non-pathological astrocytes secrete EVs, which suppress neuronal death after ischemia, resist oxidative stress, and promote plastic changes in neurons. Astrocytes in a pro-inflammatory environment secrete EVs which further enhance inflammation, neuronal death, and suppression of plastic rearrangements in neurons after ischemia. The review summarizes the latest results on the role of astrocytic EVs in the functioning of neurons and attempts to generalize the results.

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REFERENCES

  1. Feigin, V.L., Nguyen, G., Cercy, K., Johnson, C.O., Alam, T., Parmar, P.G., Abajobir, A.A., Abate, K.H., Abd-Allah, F., Abejie, A.N., Abyu, G.Y., Ademi, Z., Agarwal, G., Ahmed, M.B., Akinyemi, R.O., Al-Raddadi, R., Aminde, L.N., Amlie-Lefond, C., Ansari, H., Asayesh, H., Asgedom, S.W., Atey, T.M., Ayele, H.T., Banach, M., Banerjee, A., Barac, A., Barker-Collo, S.L., Barnighausen, T., Barregard, L., Basu, S., Bedi, N., Behzadifar, M., Bejot, Y., Bennett, D.A., Bensenor, I.M., Berhe, D.F., Boneya, D.J., Brainin, M., Campos-Nonato, I.R., Caso, V., Castaneda-Orjuela, C.A., Rivas, J.C., Catala-Lopez, F., Christensen, H., Criqui, M.H., Damasceno, A., Dandona, L., Dandona, R., Davletov, K., de Courten, B., Dokova, K., Edessa, D., Endres, M., Faraon, E.J.A., Farvid, M.S., Fischer, F., Foreman, K., Forouzanfar, M.H., Gall, S.L., Gebrehiwot, T.T., Geleijnse, J.M., Gillum, R.F., Giroud, M., Goulart, A.C., Gupta, R., Hachinski, V., Hamadeh, R.R., Hankey, G.J., Hareri, H.A., Havmoeller, R., Hay, S.I., Hegazy, M.I., Hibstu, D.T., James, S.L., Jeemon, P., John, D., Jonas, J.B., Jozwiak, J., Kalani, R., Kandel, A., Kasaeian, A., Kengne, A.P., Khader, Y.S., Khan, A.R., Khang, Y.H., Khubchandani, J., Kim, D., Kim, Y.J., Kivimaki, M., Kokubo, Y., Kolte, D., Kopec, J.A., Kosen, S., Kravchenko, M., Krishnamurthi, R., Kumar, G.A., Lafranconi, A., Lavados, P.M., Legesse, Y., Li, Y.M., Liang, X.F., Lo, W.D., Lorkowski, S., Lotufo, P.A., Loy, C.T., Mackay, M.T., Abd, El., Razek, H.M., Mahdavi, M., Majeed, A., Malekzadeh, R., Malta, D.C., Mamun, A.A., Mantovani, L.G., Martins, S.C.O., Mate, K.K., Mazidi, M., Mehata, S., Meier, T., Melaku, Y.A., Mendoza, W., Mensah, G.A., Meretoja, A., Mezgebe, H.B., Miazgowski, T., Miller, T.R., Ibrahim, N.M., Mohammed, S., Mokdad, A.H., Moosazadeh, M., Moran, A.E., Musa, K.I., Negoi, R.I., Nguyen, M., Nguyen, Q.L., Nguyen, T.H., Tran, T.T., Nguyen, T.T., Ningrum, D.N.A., Norrving, B., Noubiap, J.J., O’Donnell, M.J., Olagunju, A.T., Onuma, O.K., Owolabi, M.O., Parsaeian, M., Patton, G.C., Piradov, M., Pletcher, M.A., Pourmalek, F., Prakash, V., Qorbani, M., Rahman, M., Rahman, M.A., Rai, R.K., Ranta, A., Rawaf, D., Rawaf, S., Renzaho, A.M.N., Robinson, S.R., Sahathevan, R., Sahebkar, A., Salomon, J.A., Santalucia, P., Santos, I.S., Sartorius, B., Schutte, A.E., Sepanlou, S.G., Shafieesabet, A., Shaikh, M.A., Shamsizadeh, M., Sheth, K.N., Sisay, M., Shin, M.J., Shiue, I., Silva, D.A.S., Sobngwi, E., Soljak, M., Sorensen, R.J.D., Sposato, L.A., Stranges, S., Suliankatchi, R.A., Tabares-Seisdedos, R., Tanne, D., Nguyen, C.T., Thakur, J.S., Thrift, A.G., Tirschwell, D.L., Topor-Madry, R., Tran, B.X., Nguyen, L.T., Truelsen, T., Tsilimparis, N., Tyrovolas, S., Ukwaja, K.N., Uthman, O.A., Varakin, Y., Vasankari, T., Venketasubramanian, N., Vlassov, V.V., Wang, W.Z., Werdecker, A., Wolfe, C.D.A., Xu, G.L., Yano, Y., Yonemoto, N., Yu, C.H., Zaidi, Z., Zaki, M.E., Zhou, M.G., Ziaeian, B., Zipkin, B., Vos, T., Naghavi, M., Murray, C.J.L., Roth, G.A., and Stroke, G.B.D.L., R, N. Engl. J. Med., 2018, vol. 379, no. 25, pp. 2429–2437.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Broughton, B., Reutens, D., and Sobey, C., Stroke, 2009, vol. 40, no. 5, pp. E331–E339.

    Article  PubMed  Google Scholar 

  3. Khan, H., Pan, J.J., Li, Y.F., Zhang, Z.J., and Yang, G.Y., Front. Cell Dev. Biol., 2021, vol. 9.

  4. Zhao, S., Sheng, S.Y., Wang, Y., Ding, L., Xu, X.N., Xia, X.H., and Zheng, J.L.C., Neurosci. Biobehav. Rev., 2021, vol. 125, pp. 148–159.

    Article  CAS  PubMed  Google Scholar 

  5. Thery, C., Witwer, K.W., Aikawa, E., Alcaraz, M.J., Anderson, J.D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G.K., Ayre, D.C., Bach, J.M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N.N., Baxter, A.A., Bebawy, M., Beckham, C., Zavec, A.B., Benmoussa, A., Berardi, A.C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borras, F.E., Bosch, S., Boulanger, C.M., Breakefield, X., Breglio, A.M., Brennan, M.A., Brigstock, D.R., Brisson, A., Broekman, M.L.D., Bromberg, J.F., Bryl-Gorecka, P., Buch, S., Buck, A.H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzas, E.I., Byrd, J.B., Camussi, G., Carter, D.R.F., Caruso, S., Chamley, L.W., Chang, Y.T., Chen, C.C., Chen, S., Cheng, L., Chin, A.R., Clayton, A., Clerici, S.P., Cocks, A., Cocucci, E., Coffey, R.J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F.A. W., Coyle, B., Crescitelli, R., Criado, M.F., d’Souza-Schorey, C., Das, S., Chaudhuri, A.D., de Candia, P., de Santana, E.F., de Wever, O., del Portillo, H.A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., di Vizio, D., Dieterich, L.E., Dolo, V., Rubio, A.P.D., Dominici, M., Dourado, M.R., Driedonks, T.A.P., Duarte, F.V., Duncan, H.M., Eichenberger, R.M., Ekstrom, K., Andaloussi, S.E.L., Elie-Caille, C., Erdbrugger, U., Falcon-Perez, J.M., Fatima, F., Fish, J.E., Flores-Bellver, M., Forsonits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gamez-Valero, A., Gardiner, C., Gartner, K., Gaudin, R., Gho, Y.S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D.C.I., Gorgens, A., Gorski, S.M., Greening, D.W., Gross, J.C., Gualerzi, A., Gupta, G.N., Gustafson, D., Handberg, A., Haraszti, R.A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A.F., Hochberg, F.H., Hoffmann, K.F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G.K., Huang, Y.Y., Huber, V., Hunt, S., Ibrahim, A.G.E., Ikezu, T., Inal, J.M., Isin, M., Ivanova, A., Jackson, H.K., Jacobsen, S., Jay, S.M., Jayachandran, M., Jenster, G., Jiang, L.Z., Johnson, S.M., Jones, J.C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S., Kaur, S., Kawamura, Y., Keller, E.T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K.P., Kislinger, T., Klingeborn, M., Klinke, D.J., Kornek, M., Kosanovic, M.M., Kovacs, A.F., Kramer-Albers, E.M., Krasemann, S., Krause, M., Kurochkin, I.V., Kusuma, G.D., Kuypers, S., Laitinen, S., Langevin, S.M., Languino, L.R., Lannigan, J., Lasser, C., Laurent, L.C., Lavieu, G., Lazaro-Ibanez, E., le Lay, S., Lee, M.S., Lee, Y.X.F., Lemos, D.S., Lenassi, M., Leszczynska, A., Li, I.T.S., Liao, K., Libregts S.F., Ligeti, E., Lim, R., Lim, S.K., Line, A., Linnemannstons, K., Lombard, C.A., Lorenowicz, M.J., Lorincz, A.M., Lotvall, J., Lovett, J., Lowry, M.C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T.R., Maas, S.L.N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E.S., Martin-Jaular, L., Martinez, M.C., Martins, V.R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L.K., McVey, M.J., Meckes, D.G., Meehan, K.L., Mertens, I., Minciacchi, V.R., Moller, A., Jorgensen, M.M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D.C., Myburgh, K.H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J.P., Nolte, T., Hoen, E.N.M., Hooten, N.N., O’Driscoll, L., O’Grady, T., O’Loughlin, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L.A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D.M., Peinado, H., Perut, F., Pfaffl, M.W., Phinney, D.G., Pieters, B.C.H., Pink, R.C., Pisetsky, D.S., von Strandmann, E.P., Polakovicova, I., Poon, I.K.H., Powell, B.H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R.L., Raimondo, S., Rak, J., Ramirez, M.I., Raposo, G., Rayyan, M.S., Regev-Rudzki, N., Ricklefs, F.L., Robbins P.D., Roberts, D.D., Rodrigues, S.C., Rohde, E., Rome, S., Rouschop, K.M.A., Rughetti, A., Russell, A.E., Saa, P., Sahoo, S., Salas-Huenuleo, E., Sanchez, C., Saugstad, J.A., Saul, M.J., Schiffelers, R.M., Schneider, R., Schoyen, T.H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G.V., Shetty, A.K., Shiba K., Siljander, P.R.M., Silva, A.M., Skowronek, A., Snyder, O.L., Soares, R.P., Sodar, B.W., Soekmadji, C., Sotillo, J., Stahl, P.D., Stoorvogel, W., Stott, S.L., Strasser, E.F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W.S., Tomasini, R., Torrecilhas, A.C., Tosar, J.P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B.W.M., van der Grein, S.G., Van Deun, J., van Herwijnen, M.J.C., Van Keuren-Jensen K., van Niel, G., van Royen, M.E., van Wijnen, A.J., Vasconcelos, M.H., Vechetti, I.J., Veit, T.D., Vella, L.J., Velot, E., Verweij, F.J., Vestad, B., Vinas, J.L., Visnovitz, T., Vukman, K.V., Wahlgren, J., Watson, D. C., Wauben, M.H.M., Weaver, A., Webber, J.P., Weber, V., Wehman, A.M., Weiss, D.J., Welsh, J.A., Wendt, S., Wheelock, A.M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X.M., Yanez-Mo, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Zekas, V., Zhang, J. Y., Zhao, Z.Z., Zheng, L., Zheutlin, A.R., Zickler, A.M., Zimmermann, P., Zivkovic, A.M., Zocco, D., and Zuba-Surma, E. K., J. Extracell. Vesicles, 2018, vol. 7, no. 1.

  6. Shushkova, N.A., Novikova, S.E., and Zgoda, V.G., Biochemistry (Moscow), Suppl. B: Biomed. Chem., 2020, vol. 14, no. 2, pp. 105–115.

  7. Semina, E.V., Rysenkova, K.D., Troyanovskiy, K.E., Shmakova, A.A., and Rubina, K.A., Biochemistry (Moscow), 2021, vol. 86, no. 7, pp. 785–799.

  8. Martins, T.S., Trindade, D., Vaz, M., Campelo, I., Almeida, M., Trigo, G., Silva, O., and Henriques, A.G., J. Neurochem., 2021, vol. 156, no. 2, pp. 162–181.

    Article  CAS  Google Scholar 

  9. Ardashirova, N.S., Fedotova, E.Y., and Illarioshkin, S.N., Neurochem. J., 2020, vol. 14, no. 2, pp. 127–132.

    Article  CAS  Google Scholar 

  10. Yu, H.Y., Sun, T., An, J., Wen, L.L., Liu, F., Bu, Z.Q., Cui, Y.R., and Feng, J., Front. Cell Dev. Biol., 2020, vol. 8.

  11. Ivanova, M.V., Chekanova, E.O., Belugin, B.V., Dolzhikova, I.V., Tutykhina, I.L., and Zakharova, M.N., Neurochem. J., 2020, vol. 14, no. 3, pp. 321–327.

    Article  CAS  Google Scholar 

  12. Gagliardi, D., Bresolin, N., Comi, G.P., and Corti, S., Cell. Mol. Life Sci., 2021, vol. 78, no. 2, pp. 561–572.

    Article  CAS  PubMed  Google Scholar 

  13. Dolcetti, E., Bruno, A., Guadalupi, L., Rizzo, F.R., Musella, A., Gentile, A., De Vito, F., Caioli, S., Bullitta, S., Fresegna, D., Vanni, V., Balletta, S., Sanna, K., Buttari, F., Bassi, M.S., Centonze, D., and Mandolesi, G., Int. J. Mol. Sci., 2020, vol. 21, no. 19.

  14. Choi, J., Kim, S.Y., Kim, H., Lim, B.C., Hwang, H., Chae, J.H., Kim, K.J., Oh, S., Kim, E.Y., and Shin, J.S., BMC Neurol., 2020, vol. 20, no. 1.

  15. Gruzdev, S.K., Yakovlev, A.A., Druzhkova, T.A., Guekht, A.B., and Gulyaeva, N.V., Cell. Mol. Neurobiol., 2019, vol. 39, no. 6, pp. 729–750.

    Article  CAS  PubMed  Google Scholar 

  16. Yakovlev, A.A., Druzhkova, T.A., Nikolaev, R.V., Kuznetsova, V.E., Gruzdev, S.K., Guekht, A.B., and Gulyaeva, N.V., Neurochem. J., 2019, vol. 13, no. 4, pp. 385–390.

    Article  CAS  Google Scholar 

  17. Nasca, C., Dobbin, J., Bigio, B., Watson, K., de Angelis, P., Kautz, M., Cochran, A., Mathe, A.A., Kocsis, J.H., Lee, F.S., Murrough, J.W., McEwen, B.S., and Rasgon, N., Mol. Psychiatry, 2021, vol. 26, no. 9, pp. 5140–5149.

    Article  CAS  PubMed  Google Scholar 

  18. Amoah, S.K., Rodriguez, B.A., Logothetis, C.N., Chander, P., Sellgren, C.M., Weick, J.P., Sheridan, S.D., Jantzie, L.L., Webster, M.J., and Mellios, N., Neuropsychopharmacology, 2020, vol. 45, no. 4, pp. 656–665.

    Article  CAS  PubMed  Google Scholar 

  19. Ceylan, D., Tufekci, K.U., Keskinoglu, P., Genc, S., and Ozerdem, A., J. Affect. Disord., 2020, vol. 262, pp. 99–107.

    Article  CAS  PubMed  Google Scholar 

  20. Boulestreau, J., Maumus, M., Rozier, P., Jorgensen, C., and Noel, D., Front. Cell Dev. Biol., 2020, vol. 8.

  21. Ma, Y.Z., Li, C.H., Huang, Y.L., Wang, Y., Xia, X.H., and Zheng, J.L.C., Cell Commun. Signal., 2019, vol. 17, no. 1.

  22. Sharma, P., Mesci, P., Carromeu, C., McClatchy, D.R., Schiapparelli, L., Yates, J.R., Muotri, A.R., and Cline, H.T., Proc. Natl. Acad. Sci. U.S.A., 2019, vol. 116, no. 32, pp. 16086–16094.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Gomez-Molina, C., Sandoval, M., Henzi, R., Ramirez, J.P., Varas-Godoy, M., Luarte, A., Lafourcade, C.A., Lopez-Verrilli, A., Smalla, K.H., Kaehne, T., and Wyneken, U., Int. J. Neuropsychopharmacol., 2019, vol. 22, no. 3, pp. 232–246.

    Article  CAS  PubMed  Google Scholar 

  24. Yakovlev, A.A., Lyzhin, A.A., Aleksandrova, O.P., Khaspekov, L.G., and Gulyaeva, N.V., Biochemistry, (Moscow), Suppl. B: Biomed. Chem., 2020, vol. 14, no. 1, pp. 1–5.

  25. Kalluri, R. and LeBleu, V.S., Science, 2020, vol. 367, no. 6478, p. 6977.

    Article  CAS  Google Scholar 

  26. O’Brien, K., Breyne, K., Ughetto, S., Laurent, L.C., and Breakefield, X.O., Nat. Rev. Mol. Cell. Biol., 2020, vol. 21, no. 10, pp. 585–606.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Belhadj, Z., He, B., Deng, H.L., Song, S.Y., Zhang, H., Wang, X.Q., Dai, W.B., and Zhang, Q., J. Extracell. Vesicles, 2020, vol. 9, no. 1.

  28. Kamerkar, S., LeBleu, V.S., Sugimoto, H., Yang, S.J., Ruivo, C.F., Melo, S.A., Lee, J.J., and Kalluri, R., Nature, 2017, vol. 546, no. 7659, p. 498.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Banks, W.A., Sharma, P., Bullock, K.M., Hansen, K.M., Ludwig, N., and Whiteside, T.L., Int. J. Mol. Sci., 2020, vol. 21, no. 12.

  30. Shi, M., Sheng, L.F., Stewart, T., Zabetian, C.P., and Zhang, J., Prog. Neurobiol., 2019, vol. 175, pp. 96–106.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Tkach, M. and Thery, C., Cell, 2016, vol. 164, no. 6, pp. 1226–1232.

    Article  CAS  PubMed  Google Scholar 

  32. Falchi, A.M., Sogos, V., Saba, F., Piras, M., Congiu, T., and Piludu, M., Histochem. Cell. Biol., 2013, vol. 139, no. 2, pp. 221–231.

    Article  CAS  PubMed  Google Scholar 

  33. Hayakawa, K., Esposito, E., Wang, X.H., Terasaki, Y., Liu, Y., Xing, C.H., Ji, X.M., and Lo, E.H., Nature, 2016, vol. 535, no. 7613, p. 551.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Li, X.W., Li, Y.L., Zhang, Z.Q., Bian, Q.H., Gao, Z., and Zhang, S., Neurosci. Let., 2021, vol. 756, p. 135940.

  35. Pascua-Maestro, R., Diez-Hermano, S., Lillo, C., Ganfornina, M.D., and Sanchez, D., PLoS Genet., 2017, vol. 13, no. 2, p. e1006603.

  36. Pascua-Maestro, R., Gonzalez, E., Lillo, C., Ganfornina, M.D., Falcon-Perez, J.M., and Sanchez, D., Front. Cell. Neurosci., 2019, vol. 12, p. 526.

  37. Wang, S.W., Cesca, F., Loers, G., Schweizer, M., Buck, F., Benfenati, F., Schachner, M., and Kleene, R., J. Neurosci., 2011, vol. 31, no. 20, pp. 7275–7290.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Hira, K., Ueno, Y., Tanaka, R., Miyamoto, N., Yamashiro, K., Inaba, T., Urabe, T., Okano, H., and Hattori, N., Stroke, 2018, vol. 49, no. 10, pp. 2483–2494.

    Article  CAS  PubMed  Google Scholar 

  39. Patel, M.R. and Weaver, A.M., Cell Re, vol. 34, no. 10, p. 108829.

  40. Pei, X.X., Li, Y.C., Zhu, L.F., and Zhou, Z.L., Exp. Cell Res., 2019, vol. 382, nos. 2–3, p. 111474.

  41. Pei, X.X., Li, Y.C., Zhu, L.F., and Zhou, Z.L., Cell Cycle, 2020, vol. 19, no. 8, pp. 906–917.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Bu, X.C., Li, D., Wang, F., Sun, Q.M., and Zhang, Z.X., Neuropsychiatr. Dis. Treat., 2020, vol. 16, pp. 1863–1877.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Jing, C., Wang, L., Liu, P., Wu, C., Ruan, D., and Chen, G., Neuroscience, 2012, vol. 213, pp. 144–153.

    Article  CAS  PubMed  Google Scholar 

  44. Qi, Z., Luo, Y., Liu, X., Wang, R., Zhao, H., Yan, F., Song, Z., Luo, M., and Ji, X., CNS Neurosci. Ther., 2012, vol. 18, no. 12, pp. 965–973.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Jiang, T., Yu, J.T., Zhu, X.C., Zhang, Q.Q., Tan, M.S., Cao, L., Wang, H.F., Shi, J.Q., Gao, L., Qin, H., Zhang, Y.D., and Tan, L., Mol. Neurobiol, 2015, vol. 51, no. 1, pp. 220–229.

    Article  CAS  PubMed  Google Scholar 

  46. Bu, Q., Liu, X., Zhu, Y., Liu, Y., and Wang, Y., Brain Res., 2014, vol. 1558, pp. 100–108.

    Article  CAS  PubMed  Google Scholar 

  47. Grishchuk, Y., Ginet, V., Truttmann, A., Clarke, P., and Puyal, J., Autophagy, 2011, vol. 7, no. 10, pp. 1115–1131.

    Article  CAS  PubMed  Google Scholar 

  48. Maiuri, M.C., Zalckvar, E., Kimchi, A., and Kroemer, G., Nat. Rev. Mol. Cell Biol., 2007, vol. 8, no. 9, pp. 741–752.

    Article  CAS  PubMed  Google Scholar 

  49. Levine, B. and Yuan, J.Y., J. Clin. Invest., 2005, vol. 115, no. 10, pp. 2679–2688.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Bove, J., Martinez-Vicente, M., and Vila, M., Nat. Rev. Neurosci., 2011, vol. 12, no. 8, pp. 437–452.

    Article  CAS  PubMed  Google Scholar 

  51. Harris, H. and Rubinsztein, D.C., Nat. Rev. Neurol., 2012, vol. 8, no. 2, pp. 108–117.

    Article  CAS  Google Scholar 

  52. Xu, Y., Zhou, Y.Y., Yu, D.J., Hu, W.J., Wu, X.D., Wang, J.F., Huang, S.M., Zhao, S.C., Fan, X.L., Chu, Z.H., and Ma, L.S., Neurochem. J., 2021, vol. 15, no. 3, pp. 247–253.

    Article  CAS  Google Scholar 

  53. Chaudhuri, A.D., Dasgheyb, R.M., DeVine, L.R., Bi, H.H., Cole, R.N., and Haughey, N.J., Glia, 2020, vol. 68, no. 1, pp. 128–144.

    Article  Google Scholar 

  54. Chaudhuri, A.D., Dastgheyb, R.M., Yoo, S.W., Trout, A., Talbot, C.C., Hao, H.P., Witwer, K.W., and Haughey, N.J., Cell Death D, 2018, vol. 9, p. 363.

  55. You, Y., Borgmann, K., Edara, V.V., Stacy, S., Ghorpade, A., and Ikezu, T., J. Extracell. Vesicles, 2020, vol. 9, no. 1, p. 1706801.

  56. Chen, Z., Tang, H.B., Kang, J.J., Chen, Z.Y., Li, Y.L., Fan, Q.Y., Zhang, L., Song, Y.H., Zhang, G.L., and Fan, H., Brain Res. Bull, 2021, vol. 177, pp. 73–80.

    Article  CAS  PubMed  Google Scholar 

  57. Dickens, A.M., Tovar-y-Romo, L.B., Yoo, S.W., Trout, A.L., Bae, M., Kanmogne, M., Megra, B., Williams, D.W., Witwer, K.W., Gacias, M., Tabatadze, N., Cole, R.N., Casaccia, P., Berman, J.W., Anthony, D.C., and Haughey, N.J., Sci. Signal, 2017, vol. 10, no. 473, p. eaai7696.

  58. Menck, K., Sonmezer, C., Worst, T.S., Schulz, M., Dihazi, G.H., Streit, F., Erdmann, G., Kling, S., Boutros, M., Binder, C., and Gross, J.C., J. Extracell. Vesicles, 2017, vol. 6, no. 1, p. 1378056.

  59. Pawluk, H., Wozniak, A., Grzesk, G., Kolodziejska, R., Kozakiewicz, M., Kopkowska, E., Grzechowiak, E., and Kozera, G., Clin. Interv. Aging, 2020, vol. 15, pp. 469–484.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Iadecolar, C., Buckwalter, M.S., and Anrather, J., J. Clin. Invest., 2020, vol. 130, no. 6, pp. 2777–2788.

    Article  Google Scholar 

  61. Lopez-Perez, O., Sanz-Rubio, D., Hernaiz, A., Betancor, M., Otero, A., Castilla, J., Andreoletti, O., Badiola, J.J., Zaragoza, P., Bolea, R., Toivonen, J.M., and Martin-Burriel, I., Int. J. Mol. Sci., 2021, vol. 22, no. 13, p. 6822.

  62. Falker, C., Hartmann, A., Guett, I., Dohler, F., Altmeppen, H., Betzel, C., Schubert, R., Thurm, D., Wegwitz, F., Joshi, P., Verderio, C., Krasemann, S., and Glatzel, M., J. Neurochem., 2016, vol. 137, no. 1, pp. 88–100.

    Article  CAS  PubMed  Google Scholar 

  63. Faure, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., Kirchhoff, F., Raposo, G., Garin, J., and Sadoul, R., Mol. Cell. Neurosci., 2006, vol. 31, no. 4, pp. 642–648.

    Article  CAS  PubMed  Google Scholar 

  64. Puig, B., Altmeppen, H., and Glatzel, M., Prion, 2014, vol. 8, no. 1, pp. 11–18.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Guitart, K., Loers, G., Buck, F., Bork, U., Schachner, M., and Kleene, R., Glia, 2016, vol. 64, no. 6, pp. 896–910.

    PubMed  Google Scholar 

  66. Spudich, A., Frigg, R., Kilic, E., Kilic, U., Oesch, B., Raeber, A., Bassetti, C., and Hermann, D., Neurobiol. Dis., 2005, vol. 20, no. 2, pp. 442–449.

  67. Doeppner, T.R., Kaltwasser, B., Schlechter, J., Jaschke, J., Kilic, E., Bahr, M., Hermann, D.M., and Weise, J., Cell Death Dis., 2015, vol. 6.

  68. Doeppner, T.R., Herz, J., Goergens, A., Schlechter, J., Ludwig, A.-K., Radtke, S., de Miroschedji, K., Horn, P.A., Giebel, B., and Hermann, D.M., Stem Cells Transl. Med., 2015, vol. 4, no. 10, pp. 1131–1143.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Brenna, S., Altmeppen, H.C., Mohammadi, B., Rissiek, B., Schlink, F., Ludewig, P., Krisp, C., Schluter, H., Failla, A.V., Schneider, C., Glatzel, M., Puig, B., and Magnus, T., J. Extracell. Vesicles, 2020, vol. 9, no. 1, p. 1809065.

  70. Becerra-Calixto, A. and Cardona-Gomez, G.P., Front. Mol. Neurosci., 2017, vol. 10, p. 88.

  71. D’Arrigo, G., Gabrielli, M., Scaroni, F., Swuec, P., Amin, L., Pegoraro, A., Adinolfi, E., Di Virgilio, F., Cojoc, D., Legname, G., and Verderio, C., J. Extracell. Vesicles, 2021, vol. 10, no. 9, p. e12114.

  72. Heusermann, W., Hean, J., Trojer, D., Steib, E., von Bueren, S., Graff-Meyer, A., Genoud, C., Martin, K., Pizzato, N., Voshol, J., Morrissey, D.V., Andaloussi, S.E.L., Wood, M.J., and Meisner-Kober, N.C., J. Cell Biol., 2016, vol. 213, no. 2, pp. 173–184.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. Lehmann, M.J., Sherer, N.M., Marks, C.B., Pypaert, M., and Mothes, W., J. Cell Biol., 2005, vol. 170, no. 2, pp. 317–325.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Funding

The study was supported by a grant from the Russian Science Foundation (project no. 21-75-20112).

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  1. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. A. Yakovlev

  2. Solovyov Scientific and Practical Psychoneurological Center, Moscow Healthcare Department, Moscow, Russia

    A. A. Yakovlev

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Abbreviations: AMPK, AMP-activated protein kinase; Atg7, an autophagy-associated protein 7; BDNF, brain-derived neurotrophic factor; GDNF, glial cell-derived neurotrophic factor; L1CAM, protein L1; mTOR, mammalian target of rapamycin; NCAM, neuronal cell adhesion molecule; PrP, prion protein; TNF alpha, tumor necrosis factor alpha; EV, extracellular vesicles.

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Yakovlev, A.A. Neuroprotective Effects of Astrocyte Extracellular Vesicles in Stroke. Neurochem. J. 16, 121–129 (2022). https://doi.org/10.1134/S1819712422020143

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