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A Convenient One-Pot Synthesis of 5-Aryl-N-cyclohexyl-1,3,4-oxadiazole-2-carboxamides via Aza-Wittig/Isocyanide-based Three-Component Reaction

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Abstract

An efficient approach for the synthesis of a novel library of 1,3,4-oxadiazole-2-carboxamide analogs has been developed through one-pot three-component catalyst-free aza-Wittig reaction of cyclohexyl isocyanate, N-isocyaniminotriphenylphosphorane, and substituted benzoic acids in methylene chloride. High yields of the target compounds were obtained at room temperature. The structure of the synthesized compounds was con­firmed by NMR, IR, and mass spectra and elemental analyses.

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Authors and Affiliations

  1. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    M. B. Rastkar, B. Mohtat & G. B. Marandi

  2. Department of Chemistry, East Tehran Branch, Islamic Azad University, Tehran, Iran

    H. Djahaniani

Authors
  1. M. B. Rastkar
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  2. B. Mohtat
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  3. G. B. Marandi
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  4. H. Djahaniani
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Correspondence to B. Mohtat.

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Rastkar, M.B., Mohtat, B., Marandi, G.B. et al. A Convenient One-Pot Synthesis of 5-Aryl-N-cyclohexyl-1,3,4-oxadiazole-2-carboxamides via Aza-Wittig/Isocyanide-based Three-Component Reaction. Russ J Org Chem 58, 1035–1041 (2022). https://doi.org/10.1134/S1070428022070144

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