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One-Pot Multiсomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents

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Abstract

A new, facile, and environment friendly synthesis of some novel pyrazolylpyrazoline derivatives has been achieved using one-pot multicomponent reaction of substituted aromatic aldehydes, 2-acetylpyrrole or 2-acetyl-1,3-thiazole, and substituted hydrazines in the presence of sodium hydroxide in ethanol at room temperature under ultrasonication. The salient features of this green protocol are one-pot reaction, short reaction time, and straightforward workup procedure. All synthesized compounds were characterized by spectroscopic techniques, and their in vitro antitubercular and antimalarial activities were evaluated. Some of the compounds tested showed good to excellent activity compared to standard drugs.

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ACKNOWLEDGMENTS

The authors are thankful to the Head, M.G. Science Institute Department of Chemistry, Ahmedabad Gujarat University, for providing research facilities.

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  1. Department of Chemistry, Faculty of Science, M.G. Science Institute, Gujarat University, 380009, Ahmedabad, Gujarat, India

    M. J. Zala & J. J. Vora

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  1. M. J. Zala
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  2. J. J. Vora
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Correspondence to M. J. Zala.

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Zala, M.J., Vora, J.J. One-Pot Multiсomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents. Russ J Org Chem 57, 1725–1732 (2021). https://doi.org/10.1134/S1070428021100225

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  • DOI: https://doi.org/10.1134/S1070428021100225

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