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Synthesis and Antibacterial Activity of New Polyheteroconjugated and Dinuclear Systems Based on N-Substituted 2-Imino-2,5-dihydrofuran-3-carboxamides

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Abstract

Reactions of N-substituted 2-imino-2,5-dihydrofuran-3-carboxamides with thiosemicarbazide gave their new polyconjugated derivatives containing a thiourea fragment. Further condensation of these compounds with ethyl chloroacetate involved closure of thiazolidine ring with the formation of dinuclear polyconjugated heterocyclic systems. The synthesized compounds showed moderate to good antibacterial activity against gram-positive (Staphylococcus aureus 209p, Bacilus subtilis) and gram-negative bacteria (Shigella Flexneri 6858, Escherichia coli 0-55) which was lower than the activity of furazolidone.

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Authors and Affiliations

  1. Yerevan State University, 0025, Yerevan, Armenia

    L. V. Karapetyan & G. G. Tokmajyan

  2. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    R. V. Paronikyan

Authors
  1. L. V. Karapetyan
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  2. G. G. Tokmajyan
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  3. R. V. Paronikyan
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Correspondence to L. V. Karapetyan.

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Karapetyan, L.V., Tokmajyan, G.G. & Paronikyan, R.V. Synthesis and Antibacterial Activity of New Polyheteroconjugated and Dinuclear Systems Based on N-Substituted 2-Imino-2,5-dihydrofuran-3-carboxamides. Russ J Org Chem 57, 131–134 (2021). https://doi.org/10.1134/S1070428021010206

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  • DOI: https://doi.org/10.1134/S1070428021010206

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