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Synthesis of ferrocenyl-containing heterocyclic derivatives of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin for sonodynamic therapy

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Abstract

The condensation of 1-(ferrocenylalkyl)pyrazole-3-carbaldehydes with 4′-aminotetraphenylporphyrin, followed by reduction with NaBH(OAc)3 in 1,2-dichloroethane, provides a convenient method for the synthesis of 5-{4-[({1-[1-(ferrocen-1-yl)alkyl]-5-methyl-1H-pyrazol-3-yl}methyl)amino]phenyl}-10,15,20-triphenylporphyrins which exhibit pronounced cytotoxicity against Staphylococcus aureus under ultrasonic irradiation.

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Authors and Affiliations

  1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, ul. Vavilova 28, Moscow, 119991, Russia

    E. Yu. Osipova, A. N. Rodionov, Yu. A. Belousov, M. M. Il’in & A. A. Simenel

  2. Faculty of Chemistry, Moscow State University, Vorob’evy gory 1, Moscow, 119991, Russia

    A. L. Nikolaev, A. V. Gopin & S. E. Mazina

  3. “Moscow Institute of Steel and Alloys” National University of Science and Technology, Leninskii pr. 2, Moscow, 119049, Russia

    A. A. Simenel

Authors
  1. E. Yu. Osipova
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  2. A. N. Rodionov
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  3. Yu. A. Belousov
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  4. M. M. Il’in
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  5. A. L. Nikolaev
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  6. A. V. Gopin
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  7. S. E. Mazina
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  8. A. A. Simenel
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Corresponding author

Correspondence to E. Yu. Osipova.

Additional information

Original Russian Text © E.Yu. Osipova, A.N. Rodionov, Yu.A. Belousov, M.M. Il’in, A.L. Nikolaev, A.V. Gopin, S.E. Mazina, A.A. Simenel, 2016, published in Zhurnal Organicheskoi Khimii, 2016, Vol. 52, No. 1, pp. 133–136.

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Osipova, E.Y., Rodionov, A.N., Belousov, Y.A. et al. Synthesis of ferrocenyl-containing heterocyclic derivatives of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin for sonodynamic therapy. Russ J Org Chem 52, 127–130 (2016). https://doi.org/10.1134/S1070428016010243

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  • DOI: https://doi.org/10.1134/S1070428016010243

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