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Nanofabrication of Metals and Their Compounds for Effective Medicinal and Environmental Applications (A Review)

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Abstract

The use of metal complexes has significantly advanced in the treatment of a variety of diseases. The complexes of iron, copper, cobalt, gold, titanium, ruthenium, gallium or platinum atoms have shown various medicinal activities such as anticancer, antimicrobial, antibacterial, antioxidant, antifungal and antiviral etc. However, many existing metal complexes have serious drawbacks such as lipophilicity, low water-solubility and toxicity etc. Currently, these therapeutic agents are usually solubilized using increase concentrations of surfactants and co-solvents, which often lead to unfavourable effects. Recently, researchers have been focusing on investigating the use of nanotechnology as an option to overcome these side effects. Nanoparticles (NPs) and nano medicines require less amount of drug dose which help in reducing the load of metal in the body. The NPs are reported to be less harmful when used for gene and medication delivery. Literature survey shows that nano formulation of drugs improves their characteristics and synergistic functionality. Several classes of nanocarrier systems are broadly demonstrated for packaging and administration of the novel and established drug. These nanocomposites are also been demonstrated to have a numerous other benefit, including decreased tumour growth, decreased systemic toxicity and increased therapeutic efficacy. This review paper has summarized recent developments in the field of nanotechnology and nanofabrication of metals, and their compounds for effective medicinal and environmental applications. The literature was reviewed and collected from leading indexing databases of last 10 years to find how the nanofabrication of metals improves the efficacy. The review paper may help the researchers to come up with effective and non-hazardous solutions in the field of medicinal and environmental chemistry.

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  1. Department of Chemistry, Isabella Thoburn College, 226007, Lucknow, India

    Satya, K. Hashmi, S. Gupta, N. Singh & S. Joshi

  2. Department of Chemistry, Integral University, 226026, Lucknow, India

    T. Khan

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Satya, Hashmi, K., Gupta, S. et al. Nanofabrication of Metals and Their Compounds for Effective Medicinal and Environmental Applications (A Review). Russ J Gen Chem 93, 635–665 (2023). https://doi.org/10.1134/S1070363223030209

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