Abstract
The reaction between different arylhydrazones and ninhydrin (= indene-1,2-3-trione) in acetonitrile at room temperature is described to produce novel bioactive 1-(3-chlorophenyl)indeno[1,2-c]pyrazol-4(1H)-one analouges. In evaluations of the ability to inhibit the growth of different human cell lines and some pathogenic bacterial strains in vitro, compounds 3c and 3f showed significant potency compared with the reference drugs. Both derivatives interacted well with the active site of the BRAF protein, according to molecular docking studies.
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Khalifa, N.M., Haiba, M.E., Afifi, A.H. et al. Design and Synthesis of Some New Biologically Active Indeno[1,2-c]pyrazolones. Russ J Gen Chem 92, 1728–1736 (2022). https://doi.org/10.1134/S1070363222090158
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DOI: https://doi.org/10.1134/S1070363222090158