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Reactions of Ethyl 3-(4-Oxo-4H-chromen-3-yl)prop-2-enoates with 1,2-Binucleophiles

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Abstract

Reactions of ethyl 3-(4-oxo-4H-chromen-3-yl)prop-2-enoates with 1,2-binucleophilic agents (hydrazine, phenylhydrazine, hydroxylamine) leads to the formation of some new pyrazole and isoxazole derivatives. The reactions proceed under mild conditions (ethanol, room temperature) to form the title products with high yields (71–99%).

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Funding

This work was carried out within the framework of the governmental task of the Ministry of Health of Russia (no. AAAA-A20-120121790030-8). Compounds were analyzed using the equipment of the Analytical Center of the St. Petersburg Chemical and Pharmaceutical University of the Russian Ministry of Health with the financial support of the Russian Ministry of Education and Science (project no. 075-15-2021-685).

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Authors and Affiliations

  1. St. Petersburg State Chemical Pharmaceutical University, 197376, St. Petersburg, Russia

    R. P. Kustin, N. M. Chernov, R. V. Shutov & I. P. Yakovlev

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  1. R. P. Kustin
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  2. N. M. Chernov
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  3. R. V. Shutov
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  4. I. P. Yakovlev
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Correspondence to N. M. Chernov.

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Kustin, R.P., Chernov, N.M., Shutov, R.V. et al. Reactions of Ethyl 3-(4-Oxo-4H-chromen-3-yl)prop-2-enoates with 1,2-Binucleophiles. Russ J Gen Chem 92, 1604–1609 (2022). https://doi.org/10.1134/S1070363222090031

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  • DOI: https://doi.org/10.1134/S1070363222090031

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