Skip to main content
SpringerLink
Log in

Design and Synthesis of Some New N-Phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-1-sulfonamide Derivatives and Their Anti-Cancer Activity

  • Published:
Russian Journal of General Chemistry Aims and scope Submit manuscript

Abstract

Synthesis of some new derivatives of N-phenyl-[1,2,4]triazolo [4,3-a]quinoxaline-1-sulfonamide and their in vitro anticancer activity on four human cancer lines like MCF-7 (human breast cancer cell line), HeLa (human cervical cancer cell line), A549 (human lung cancer cell line), and IMR32 (human neuroblastoma cell line) have been studied. Among the products, N-(3,5-dichloronitrophenyl)-[1,2,4] triazolo[4,3-a]quinoxaline-1-sulfonamide, is characterized by the activity higher than the standard Etoposide against the tested cancer cell lines.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Scheme 1.
Scheme 2.

Similar content being viewed by others

REFERENCES

  1. Owa, T. and Nagasu, T., Exp. Opin. Ther. Pat., 2000, vol. 10, p. 1725.

    Article  CAS  Google Scholar 

  2. Supuran, C.T. and Scozzafava, A., Exp. Opin. Ther. Pat., 2000, vol. 10, p. 575.

    Article  CAS  Google Scholar 

  3. Supuran, C.T. and Scozzafava, A., Curr. Med. Chem. Immunol., Endoc. Metab. Agents., 2001, vol. 1, p. 61. https://doi.org/10.2174/1568013013359131

    Article  CAS  Google Scholar 

  4. Rodrigues, L.D., Sunil, D., Chaithra, D., and Bhagavath, P., J. Mol. Liq., 2020, vol. 297, p. 111909. https://doi.org/10.1016/j.molliq.2019.111909

    Article  CAS  Google Scholar 

  5. Junior, C.V., Danuello, A., Bolzani, V.D.S., Barreiro, E.J., and Fraga, C.A.M., Curr. Med. Chem., 2007, vol. 14, p. 1829. https://doi.org/10.2174/092986707781058805

    Article  Google Scholar 

  6. Gediya, L.K. and Njar, V.C., Expert Opin. Drug Discov., 2009, vol. 4, p. 1099.

    Article  CAS  Google Scholar 

  7. Halise, I.G., Cem, Y., Hiroshi, S., Andrea, A., Janis, A.K., Kaspars, T., Dilan, O.O., and Claudiu, T.S., Bioorg. Chem., 2018, vol. 77, p. 411. https://doi.org/10.1016/j.bioorg.2018.01.021

    Article  CAS  Google Scholar 

  8. Kiumars, B.., Mohammad, M.K.., and Jamshid, A., Tetrahedron, 2012, vol. 68, p. 5095. https://doi.org/10.1016/j.tet.2012.04.040

    Article  CAS  Google Scholar 

  9. Tron, G.C., Pirali, T., Billington, R.A., Canonico, P.L., and Sorba, G., Med. Res. Rev., 2008, vol. 28, p. 278. https://doi.org/10.1002/med.20107

    Article  CAS  PubMed  Google Scholar 

Download references

ACKNOWLEDGMENTS

The authors are thankful to the Department of Chemistry, Chaitanya Deemed to be University for providing Laboratory facilities and Department of Biotechnology, Chaitanya Deemed to be University for their support in anticancer activity.

Author information

Authors and Affiliations

  1. Department of Chemistry, Chaitanya deemed to be University, Hanamkonda, Telanagana, 506001, Warangal, India

    Madhuri Pandiri, Satheesh Kumar Nukala, Gouthami Dasari, Vinitha Badithapuram & Srinivas Bandari

Authors
  1. Madhuri Pandiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Satheesh Kumar Nukala
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gouthami Dasari
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Vinitha Badithapuram
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Srinivas Bandari
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Srinivas Bandari.

Ethics declarations

This article does not contain any studies involving animals or human participants performed by any of the authors.

No conflict of interest was declared by the authors.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pandiri, M., Nukala, S.K., Dasari, G. et al. Design and Synthesis of Some New N-Phenyl-[1,2,4]triazolo[4,3-a]quinoxaline-1-sulfonamide Derivatives and Their Anti-Cancer Activity. Russ J Gen Chem 91, 2280–2285 (2021). https://doi.org/10.1134/S1070363221110153

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070363221110153

Keywords:

Search

Navigation