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Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents

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Abstract

Objective: Synthesis of some new coumarin-thiazolidine-2,4-dione-1,2,3-triazoles and evaluation of their anti-lung cancer activity. Methods: Well-known reaction like Knoevenagel condensation and Cu (I) catalyzed azide-alkyne cycloaddition were used. MTT assay was used in anticancer activity. Autodock tools were used foe docking studies. Results and Discussion: The fourteen compounds were screened against A549 and NCI-H460 and compared with Doxorubicin. In addition to this tubulin polymerization inhibition assay and docking studies were performed on some active compounds. Conclusions: Synthesized some new 1,2,3-triazole hybrids and tested their anticancer activity and screened for binding interaction with tubulin. Some of the compounds were found active.

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DATA AVAILABILITY

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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  1. Department of Chemistry, Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, Hyderabad, 501301, Telangana State, India

    B. Ramakrishna, B. Karthik, B. Ashok Kumar & T. Kranthi Kumar

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The author TKK—involved in designing the scheme and writing the manuscript; the author BAK—involved in screening compounds towards anticancer activity; the author BK—involved in molecular docking studies and tubulin polymerization inhibition assay; the author BR—involved in the synthesis and characterization compounds.

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Correspondence to T. Kranthi Kumar.

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Ramakrishna, B., Karthik, B., Kumar, B.A. et al. Synthesis of Some New Coumarin-thiazolidine-2,4-dione-1,2,3-triazole Hybrids as Tubulin Targeting Anti-Lung Cancer Agents. Russ J Bioorg Chem 50, 282–292 (2024). https://doi.org/10.1134/S1068162024020109

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